Human antihuman interleukin-6 antibody and fragment of antibody
First Claim
Patent Images
1. A gene fragment coding for a single chain Fv (hereinafter referred to as “
- scFv”
) of a human anti-human IL-6 antibody that binds to human IL-6 with a dissociation constant (KD) of 1.0×
10−
8 M or less,said gene fragment consisting of a gene fragment coding for a VH chain of said human anti-human IL-6 antibody bound to a gene fragment coding for a VL chain of said human anti-human IL-6 antibody;
wherein complementarity determining regions (CDR1 to CDR3) of said VH chain have the following amino acid sequences;
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Abstract
A substance effective for treating immunopathy where interleukin 6 (IL-6) is involved is provided. A human anti-human IL-6 antibody and a human anti-human IL-6 antibody fragment having a high affinity to human IL-6 were obtained using phage antibody technique. The antibody and antibody fragment are expected to be useful as a medicament for treating inflammation and immunopathy caused by IL-6.
67 Citations
2 Claims
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1. A gene fragment coding for a single chain Fv (hereinafter referred to as “
- scFv”
) of a human anti-human IL-6 antibody that binds to human IL-6 with a dissociation constant (KD) of 1.0×
10−
8 M or less,said gene fragment consisting of a gene fragment coding for a VH chain of said human anti-human IL-6 antibody bound to a gene fragment coding for a VL chain of said human anti-human IL-6 antibody; wherein complementarity determining regions (CDR1 to CDR3) of said VH chain have the following amino acid sequences;
- scFv”
-
2. A gene fragment coding for a single chain Fv (hereinafter referred to as “
- scFv”
) of a human anti-human IL-6 antibody that binds to human IL-6 with a dissactation constant (KD) of 1.0×
10−
8 M or less,said gene fragment consisting of a gene fragment coding for a VH chain of said human anti-human IL-6 antibody bound to a gene fragment coding for a VL chain of said human anti-human IL-6 antibody, wherein said VH chain has the amino acid sequence depicted in SEQ ID NO;
2 and/or said VL chain has the amino acid sequence depicted in SEQ ID NO;
4.
- scFv”
Specification
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Current AssigneeJuridical Foundation The Chemo-Sero-Therapeutic Research Institute
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Original AssigneeJuridical Foundation The Chemo-Sero-Therapeutic Research Institute
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InventorsNakashima, Toshihiro, Sasaki, Takumi, Yoshizaki, Kazuyuki, Sugimura, Kazuhisa
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Primary Examiner(s)Belyavskyi; Michail A.
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Assistant Examiner(s)SKELDING, ZACHARY S
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Application NumberUS10/526,072Publication NumberTime in Patent Office1,979 DaysField of SearchNoneUS Class Current530/388.15CPC Class CodesA61K 2039/505 comprising antibodiesA61P 19/02 for joint disorders, e.g. a...A61P 29/00 Non-central analgesic, anti...A61P 37/02 ImmunomodulatorsA61P 43/00 Drugs for specific purposes...C07K 16/005 constructed by phage librariesC07K 16/248 IL-6C07K 2317/21 from primates, e.g. manC07K 2317/622 Single chain antibody (scFv)C07K 2317/73 Inducing cell death, e.g. a...
