Feedback control device for transcutaneous drug delivery and uses therefor
First Claim
Patent Images
1. A device for altering a biological membrane in an individual comprising:
- an energy delivery system;
a housing;
a first electrode in electrical contact with a biological membrane;
a second electrode located distally from first electrode in electrical contact with said biological membrane, wherein said contact of first and second electrodes with biological membrane forms a galvanic cell;
a conductive fluid interface between said first electrode and second electrode and said biological membrane;
a controller to monitor said galvanic cell, wherein a change in current flow of galvanic cell corresponds to the change in the biological state of said target site; and
a microprocessor operably connected to said controller and to said energy delivery system, wherein said microprocessor modulates said energy delivery from said energy delivery system to first electrode in response to a change in said current flow of said galvanic cell.
1 Assignment
0 Petitions
Accused Products
Abstract
Provided herein is a device for altering a biological membrane in an individual comprising a means for delivering energy to the surface of said biological membrane; a means for monitoring a physiological state of said biological membrane during delivery of said energy; a means for modulating delivery of said energy to said biological membrane wherein said modulating is in response to a change in said monitored physiological state; and a housing means for said device. Also provided is a device to control the permeation of substance across a biological membrane and methods for use of these devices.
14 Citations
10 Claims
-
1. A device for altering a biological membrane in an individual comprising:
-
an energy delivery system; a housing; a first electrode in electrical contact with a biological membrane; a second electrode located distally from first electrode in electrical contact with said biological membrane, wherein said contact of first and second electrodes with biological membrane forms a galvanic cell; a conductive fluid interface between said first electrode and second electrode and said biological membrane; a controller to monitor said galvanic cell, wherein a change in current flow of galvanic cell corresponds to the change in the biological state of said target site; and a microprocessor operably connected to said controller and to said energy delivery system, wherein said microprocessor modulates said energy delivery from said energy delivery system to first electrode in response to a change in said current flow of said galvanic cell. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
Specification