Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy

• US 7,483,747 B2
• Filed: 07/15/2005
• Issued: 01/27/2009
• Est. Priority Date: 07/15/2004
• Status: Active Grant

• Current Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories)
• Original Assignee: Northstar Neuroscience, Inc.
• Inventors: Wyler, Allen, Fowler, Brad, Sheffield, W. Douglas, Gliner, Bradford Evan, Sloan, Leif R., Kuntz, Richard, Leyde, Kent
• Primary Examiner(s): Layno; Carl H.
• Assistant Examiner(s): Gedeon; Brian T
• Application Number:
  US11/182,713
• Publication Number:
  US 20060015153A1
• Time in Patent Office: 1,292 Days
• Field of Search: 607/45, 607/46, 607/117
• US Class Current: 607/45
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/3606 adapted for a particular treatment
• CPC Class Codes: A61N 1/36064 Epilepsy
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36103 Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke
• CPC Class Codes: A61N 1/36135 using physiological parameters
• CPC Class Codes: A61N 1/36146 specified by the stimulation parameters
• CPC Class Codes: A61N 1/37252 Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data
• CPC Class Codes: G06F 13/385 for adaptation of a particular data processing system to different peripheral devices
• CPC Class Codes: H04L 49/90 Buffering arrangements
• CPC Class Codes: H04L 49/901 using storage descriptor, e.g. read or write pointers
• CPC Class Codes: H04L 67/565 Conversion or adaptation of application format or content adding application control or application functional data H04L67/561
• CPC Class Codes: H04L 67/568 Storing data temporarily at an intermediate stage, e.g. caching
• CPC Class Codes: Y02D 10/00 Energy efficient computing, e.g. low power processors, power management or thermal management

Abstract

Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient'"'"'s nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.

Claims

1. A method for treating a neurological condition of a patient, comprising:

applying electromagnetic signals to a patient'"'"'s nervous system over a first time period with a first waveform having a first set of parameters; and

applying electromagnetic signals to the patient'"'"'s nervous system over a second time period with a second waveform having a second set of parameters, wherein at least one parameter of the second set is different than a corresponding parameter of the first set, and wherein the at least one parameter is selected to resume, at least approximately maintain, or resume and at least approximately maintain a therapeutic benefit resulting from signals applied during the first time period.

2. The method of claim 1 wherein applying electromagnetic signals over at least one of the first and second time periods includes applying electromagnetic signals at sub-threshold levels.

3. The method of claim 1 wherein applying electromagnetic signals over at least one of the first and second time periods includes applying electromagnetic signals at at least two of the following levels:

sub-threshold, threshold, and suprathreshold.

4. The method of claim 1, further comprising:

interrupting the application of electromagnetic signals between the first and second time periods; and

selecting the at least one parameter of the second set to reduce power consumption due to electromagnetic signals during the second time period compared with power consumption due to electromagnetic signals during the first time period.

5. The method of claim 4 wherein at least one of interrupting the application of electromagnetic signals and selecting the at least one parameter is performed before a power source that provides power for the electromagnetic signals is significantly depleted.

6. The method of claim 1 wherein applying electromagnetic signals over a second time period includes applying electromagnetic signals over a second time period that is sequential to the first time period.

7. The method of claim 1 wherein applying electromagnetic signals over the first time period includes applying electromagnetic signals at a first location and wherein applying electromagnetic signals over the second time period includes applying electromagnetic signals at a second location different than the first location.

8. The method of claim 1 wherein applying electromagnetic signals over a second time period includes applying electromagnetic signals over a second time period that is initiated after initiation of the first time period and completed before completion of the first time period.

9. The method of claim 1 wherein applying electromagnetic signals includes applying electromagnetic signals over multiple second time periods that are nested within the first time period.

10. The method of claim 9 wherein the first time period is hours-based and the second time period is based on a time period less than hours.

11. The method of claim 1 wherein applying electromagnetic signals during at least one of the time periods includes applying the electromagnetic signals in a manner that varies aperiodically.

12. The method of claim 11 wherein applying electromagnetic signals includes applying electromagnetic signals in a manner that varies chaotically.

13. The method of claim 11 wherein applying electromagnetic signals includes applying electromagnetic signals in a manner that corresponds at least generally to an iterative function.

14. The method of claim 11 wherein applying electromagnetic signals includes applying electromagnetic signals in a manner that corresponds at least generally to a partial sum of an infinite series.

15. The method of claim 11 wherein applying electromagnetic signals includes applying electromagnetic signals in a manner that corresponds at least generally to a metastable attractor.

32. The method of claim 1, further comprising identifying the neurological condition as including depression, and wherein applying electromagnetic signals over the first and second time periods includes applying electrical signals to electrodes implanted within the patient'"'"'s skull, via a signal generator implanted within the patient'"'"'s body.

33. The method of claim 32 wherein applying electromagnetic signals over the first and second time periods includes applying the signals from a plurality of electrical contacts positioned at a cortical surface of the patient'"'"'s brain.

16. An apparatus for treating a neurological condition of a patient, comprising:

a signal delivery device configured to be positioned in signal communication with neural tissue of a patient'"'"'s nervous system;

a signal generator;

a signal communication link operatively coupled between the signal delivery device and the signal generator; and

a controller operatively coupled to the signal generator, the controller being configured to provide instructions to the signal generator that;

direct an application of electromagnetic signals to the patient'"'"'s nervous system over a first time period with a first waveform having a first set of parameters; and

direct an application of electromagnetic signals to the patient'"'"'s nervous system over a second time period with a second waveform having a second set of parameters, wherein at least one parameter of the second set is different than a corresponding parameter of the first set and is selected to resume, at least approximately maintain, or resume and at least approximately maintain a therapeutic benefit resulting from signals directed during the first time period.

17. The apparatus of claim 16 wherein the signal generator is configured to direct application of electromagnetic signals at sub-threshold levels.

18. The apparatus of claim 16 wherein the controller includes stored instructions that direct electromagnetic signals over the first and second time periods.

19. The apparatus of claim 16 wherein the signal delivery device includes an electrode device that includes at least one electrode.

20. The apparatus of claim 16 wherein the signal generator includes an implantable pulse generator configured to be implanted in the patient.

21. The apparatus of claim 16 wherein the signal generator includes an implantable housing configured to be implanted in the patient, and wherein the housing carries a first pulse generator and a second pulse generator.

22. The apparatus of claim 21 wherein the first pulse generator is configured to deliver electromagnetic signals over the first time period, and the second pulse generator is configured to deliver electromagnetic signals over the second time period.

23. The apparatus of claim 21 wherein the first pulse generator is configured to deliver electromagnetic signals to a first location of the patient'"'"'s body and the second pulse generator is configured to deliver electromagnetic signals to a second location of the patient'"'"'s body.

24. The apparatus of claim 16 wherein the controller is configured to provide instructions that direct the application of electromagnetic signals over a second time period that is sequential to the first time period.

25. The apparatus of claim 16 wherein the controller is configured to provide instructions that direct the application of electromagnetic signals over multiple second time periods that are nested within the first time period.

26. The apparatus of claim 16 wherein the controller is configured to provide instructions that:

interrupt the application of electromagnetic signals between the first and second time periods; and

select the at least one parameter of the second set to reduce power consumption due to electromagnetic signals during the second time period compared with power consumption due to electromagnetic signals during the first time period.

27. The apparatus of claim 26, further comprising a power source coupled to the signal generator, and wherein at least one of the interrupt instruction and the select instruction is provided before the power source is significantly depleted.

28. A method for treating a neurological condition of a patient, comprising:

applying electromagnetic signals to a patient'"'"'s nervous system over a first time period with a first waveform having a first set of parameters;

applying electromagnetic signals to the patient'"'"'s nervous system over a second time period with a second waveform having a second set of parameters, wherein at least one parameter of the second set is different than a corresponding parameter of the first set and is selected to reduce power consumption due to electromagnetic signals during the second time period compared with power consumption due to electromagnetic signals during the first time period; and

interrupting the application of electromagnetic signals between the first and second time periods.

29. The method of claim 28 wherein at least one of interrupting the application of electromagnetic signals and selecting the at least one parameter is performed before a power source that provides power for the electromagnetic signals is significantly depleted.

30. An apparatus for treating a neurological condition of a patient, comprising:

a signal delivery device configured to be positioned in signal communication with neural tissue of a patient'"'"'s nervous system;

a signal generator;

a signal communication link operatively coupled between the signal delivery device and the signal generator; and

a controller operatively coupled to the signal generator, the controller being configured to provide instructions to the signal generator that;

direct an application of electromagnetic signals to the patient'"'"'s nervous system over a first time period with a first waveform having a first set of parameters;

direct an application of electromagnetic signals to the patient'"'"'s nervous system over a second time period with a second waveform having a second set of parameters, wherein at least one parameter of the second set is different than a corresponding parameter of the first set and is selected to reduce power consumption due to electromagnetic signals during the second time period compared with power consumption due to electrical signals during the first time period; and

interrupt the application of electromagnetic signals between the first and second time periods.

31. The apparatus of claim 30, further comprising a power source coupled to the signal generator, and wherein at least one of the interrupt instruction and the select instruction is provided before the power source is significantly depleted.