Method for attachment of silylated molecules to glass surfaces
First Claim
Patent Images
1. A compound having a formula vi:
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[(R1)(R2)(R3)Si—
X-Z-CYNH]2—
Si (NCY)2
viwherein R1, R2 and R3 independently represents C1-C6 alkoxy, C1-C6 alkyl, phenyl, or aryl substituted with one or more groups selected from the group consisting of C1-C6 alkyl and C1-C6 alkoxy;
X represents linear or branched C1-C20 alkyl or aryl substituted with one or more groups selected from the group consisting of C1-C6 alkyl and C1-C6 alkoxy, optionally substituted with one or more heteroatoms comprising oxygen, nitrogen, or sulfur;
Y represents oxygen or sulfur; and
Z represents oxygen or NH, with the proviso that at least one of R1, R2, or R3 represents C1-C6 alkoxy.
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Abstract
A method for the efficient immobilization of silylated molecules such as silylated oligonucleotides or proteins onto unmodified surfaces such as a glass surface is provided. Also provided are compounds, devices, and kits for modifying surfaces such as glass surfaces.
250 Citations
4 Claims
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1. A compound having a formula vi:
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[(R1)(R2)(R3)Si—
X-Z-CYNH]2—
Si (NCY)2
viwherein R1, R2 and R3 independently represents C1-C6 alkoxy, C1-C6 alkyl, phenyl, or aryl substituted with one or more groups selected from the group consisting of C1-C6 alkyl and C1-C6 alkoxy;
X represents linear or branched C1-C20 alkyl or aryl substituted with one or more groups selected from the group consisting of C1-C6 alkyl and C1-C6 alkoxy, optionally substituted with one or more heteroatoms comprising oxygen, nitrogen, or sulfur;
Y represents oxygen or sulfur; and
Z represents oxygen or NH, with the proviso that at least one of R1, R2, or R3 represents C1-C6 alkoxy.- View Dependent Claims (2)
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3. A kit comprising:
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a container comprising a compound having the formula vi;
[(R1)(R2)(R3)Si—
X-Z-CYNH]2—
Si (NCY)2
viwherein R1, R2 and R3 independently represents C1-C6 alkoxy, C1-C6 alkyl, phenyl, or aryl substituted with one or more groups selected from the group consisting of C1-C6 alkyl and C1-C6 alkoxy;
X represents linear or branched C1-C20 alkyl or aryl substituted with one or more groups selected from the group consisting of C1-C6 alkyl and C1-C6 alkoxy, optionally substituted with one or more heteroatoms comprising oxygen, nitrogen, or sulfur;
Y represents oxygen or sulfur; and
Z represents oxygen or NH, with the proviso that at least one of R1, R2, or R3 represents C1-C6 alkoxy; andan optional substrate. - View Dependent Claims (4)
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Specification
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Current AssigneeNanosphere Incorporated (DiaSorin S.p.A.)
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Original AssigneeNanosphere Incorporated (DiaSorin S.p.A.)
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InventorsGarimella, Viswanadham, Bernal, Yasmith
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Primary Examiner(s)Riley; Jezia
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Application NumberUS11/656,303Publication NumberTime in Patent Office746 DaysField of Search436/518, 436/524, 436/527, 436/106, 436/109, 435/4, 435/6, 435/174US Class Current436/518CPC Class CodesC03C 17/30 with silicon-containing com...C12Q 1/6834 Enzymatic or biochemical co...G01N 33/552 Glass or silicaY10T 436/17 Nitrogen containingY10T 436/172307 Cyanide or isocyanideY10T 436/20 Oxygen containing
