Optical non-invasive blood monitoring system and method
First Claim
1. A device for noninvasive measurement of the levels of at least one analyte in a subject that comprises:
- means for irradiating the subject through tissue with electromagnetic radiation;
means for detecting the radiation that passes through the tissue;
means for calculating the speed at which the electromagnetic radiation passes through the tissue; and
means for correlating the calculated speed of the electromagnetic radiation to the concentration of the at least one analyte in the subject.
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Accused Products
Abstract
A simple noninvasive technique that is capable of very accurate and fast blood analyte, e.g., glucose, level monitoring is provided. Fluctuation in the levels of glucose and other analytes affect the refractive index of blood and extra cellular fluid in biological tissue. Given that the propagation speed of light through a medium depends on its refractive index, continuous monitoring of analyte levels in tissue is achieved by measuring characteristics of the tissue that can be correlated to the refractive index of the tissue. For instance, the frequency or number of optical pulse revelations that are transmitted through an individual'"'"'s tissue of known thickness within a certain time period can be correlated to an individual'"'"'s blood glucose level.
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Citations
27 Claims
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1. A device for noninvasive measurement of the levels of at least one analyte in a subject that comprises:
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means for irradiating the subject through tissue with electromagnetic radiation; means for detecting the radiation that passes through the tissue; means for calculating the speed at which the electromagnetic radiation passes through the tissue; and means for correlating the calculated speed of the electromagnetic radiation to the concentration of the at least one analyte in the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A device for noninvasive measurement of the levels of glucose in a subject that comprises:
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means for irradiating the subject through tissue with electromagnetic radiation having a wavelength such that the speed of the electromagnetic radiation traversing through the tissue is sensitive to the glucose concentration in the tissue; means for detecting the radiation that passes through the tissue; means for calculating the speed at which the electromagnetic radiation passes through the tissue; and means for correlating the calculated speed of the electromagnetic radiation to the concentration of glucose in the subject. - View Dependent Claims (13, 14, 15, 16, 17)
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18. A noninvasive method of monitoring the levels of at least one analyte in a subject that comprises:
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(a) irradiating the subject through tissue of known thickness with electromagnetic radiation; (b) detecting the radiation that passes through the tissue in a transmissive mode; (c) calculating the speed at which the electromagnetic radiation passes through the tissue; and (d) correlating the calculated speed of the electromagnetic radiation to the concentration of the at least one analyte in the subject. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification