Catheter head

• US 7,486,978 B2
• Filed: 04/23/2004
• Issued: 02/03/2009
• Est. Priority Date: 04/24/2003
• Status: Expired due to Fees

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Van Beek, Michael Cornelis, Rensen, Wouter Harry Jacinth, Liedenbaum, Coen Theodorus Hubertus Fransiscus, Lucassen, Gerhardus Wilhelmus
• Primary Examiner(s): Winakur; Eric F
• Assistant Examiner(s): Berhanu; Etsub D
• Application Number:
  US10/554,352
• Publication Number:
  US 20070010727A1
• Time in Patent Office: 1,747 Days
• Field of Search: 600/310, 600/322, 600/341, 600/342, 604/6.08, 604/66
• US Class Current: 600/341
• CPC Class Codes: A61B 2562/0238 Optical sensor arrangements for performing transmission measurements on body tissue
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 6/481 involving the use of contrast agents
• CPC Class Codes: A61B 6/504 for diagnosis of blood vessels, e.g. by angiography

Abstract

The present invention relates to a catheter head comprising: means (104, 108; 306, 304; 320; 322; 326; 338) for directing of radiation to a blood detection volume (220; 310), means (104, 108; 306, 304; 320; 322; 326; 332, 334, 330; 338) for receiving of return radiation from the blood detection volume, means (104; 306; 330) for transmitting of the return radiation to means (122) for analysis of the return radiation for determination of at least one property of the blood.

Claims

1. A catheter head comprising:

at least one waveguide for directing radiation to a blood detection volume and for directing of return radiation to a spectroscopic analyzer that determines at least one property of the blood;

an objective lens for receiving the return radiation from the blood detection volume;

a housing, the detection volume being located inside a cavity of the housing, the housing having a sidewall with an opening therethrough to enable the blood to flow into the cavity;

a concave mirror at least partially forming an end of the cavity opposite to an end of the waveguide, the concave mirror being positioned relative to the at least one waveguide such that radiation emitted from the at least one waveguide;

(1) in part is scattered by the blood, which scattered radiation in part is reflected by the blood back to the end of the at least one waveguide and which scattered radiation in part passes through the blood in the cavity to the concave mirror, is reflected by the concave mirror, and passes back through the blood in the cavity to the end of the waveguide and

(2) in part passes through the blood in the cavity is reflected by the concave mirror back in to the blood in the cavity and is scattered by the blood and the scattered radiation passes to the end of the at least one waveguide.

2. The catheter head of claim 1 wherein the at least one waveguide is a single wave guide for guiding of the radiation to the blood detection volume and for receiving the return radiation for transmission to the means for spectroscopic analysis.

3. The catheter head of claim 1, wherein the objective lens is in front of the wave guide and is made from a material that reflects Raman scattered radiation.

4. The catheter head of claim 1, further comprising a channel formed through the housing and defining at least in part the cavity, wherein the channel has at least two openings with a first opening along the sidewall.

5. The catheter head of claim 1, wherein the concave mirror includes a spherical mirror configured to reflect the Raman scattered radiation back into the blood detection volume.

6. The catheter head of claim 1, wherein the concave mirror includes an ellipsoidal mirror, the blood detection volume comprising one of the focal points of the ellipsoidal mirror and a distal end of the wave guide being located at the other focal point of the ellipsoidal mirror, the mirror forming the cavity.

7. The catheter head of claim 1, further comprising a dichroic mirror that allows the radiation to pass therethrough and reflects the return radiation.

8. The catheter head of claim 1, further including:

a shutter which is controlled remote from the catheter head to selectively permit and prevent access to the blood detection volume.

9. The catheter head of claim 1 further including:

a mesh across the opening in the side wall, the mesh having openings sized to prevent at least one of red and white blood cells from entering into the cavity.

10. A catheter head comprising:

at least one waveguide for directing of radiation to a bodily fluid detection volume and for directing of return radiation to a spectroscopic analyzer that determines at least one property of the bodily fluid;

an objective lens for receiving of return radiation from the detection volume; and

a housing, the detection volume being located along a channel through the housing, the channel having at least two openings and defining a non-linear path through the housing, the detection volume being defined in the non-linear channel.

11. The catheter head of claim 10, wherein at least a portion of the channel is coated to provide the reflective surface.

12. The catheter head of claim 10, wherein an end of the cavity opposite to an end of the waveguide has a reflective surface thereon.

13. A method of in vivo analysis of blood, the method comprising:

positioning a catheter head in blood in vivo;

capturing a plasma portion of the blood in a fluid detection volume of a housing of the catheter head, including preventing at least one of red and white blood cells from entering the fluid detection volume;

generating a Raman excitation radiation;

guiding the Raman excitation radiation through the catheter head into the fluid

detection volume to produce scattered radiation;

reflecting the scattered radiation using a dichroic mirror; and

guiding the scattered radiation through the catheter head to a spectroscopic analyzer to determine at least one property of the plasma portion of the blood.

14. The method of claim 13, further comprising providing selective access to the fluid detection volume using a shutter that is remotely controlled.

15. The method of claim 13, wherein the guiding of the Raman excitation radiation and the guiding of the scattered radiation is performed by separate waveguides in the catheter head.

16. A method of in vivo analysis of a bodily fluid, the method comprising:

positioning in vivo a catheter head in proximity to the bodily fluid;

drawing a portion of the bodily fluid through a housing along a non-linear path;

generating a Raman excitation radiation;

guiding the Raman excitation radiation through the catheter head into a fluid detection volume defined in the non-linear path to produce scattered radiation; and

guiding the scattered radiation through the catheter head to a spectroscopic analyzer to determine at least one property of the bodily fluid.

17. The method of claim 16, wherein drawing the portion of the bodily fluid along the non-linear path includes using a pitot tube effect, wherein the housing has at least two openings for flow of the portion of the bodily fluid.

18. The method of claim 16, further comprising reflecting at least a portion of the scattered radiation into a waveguide that is guiding the scattered radiation through the catheter head.

19. The method of claim 16, further comprising preventing at least one of red and white blood cells from entering the fluid detection volume using a mesh.