Device for delivery of oxidizing agents to barrier membranes

• US 7,486,989 B2
• Filed: 06/30/2003
• Issued: 02/03/2009
• Est. Priority Date: 06/30/2003
• Status: Expired due to Fees

• Current Assignee: Johnson & Johnson Consumer Companies Incorporated (Johnson & Johnson)
• Original Assignee: Johnson & Johnson Consumer Companies Incorporated (Johnson & Johnson)
• Inventors: Sun, Ying, Wu, Jeffrey M., Liu, Jue-Chen
• Primary Examiner(s): Mendez; Manuel A
• Application Number:
  US10/609,849
• Publication Number:
  US 20040267231A1
• Time in Patent Office: 2,045 Days
• Field of Search: 604/20, 604/500, 604/19, 604/501, 6048901-8921, 607/2
• US Class Current: 604/20
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

The present invention features a method of treating infection in a barrier membrane by applying to the membrane a device having a barrier membrane contacting surface that administers an oxidizing agent to the barrier membrane, wherein the device contains: a power source; a first conductive electrode, wherein the first conductive electrode is an inert anode; a second conductive electrode, wherein the second conductive electrode is a cathode; and a carrier containing water; wherein the power source is in electric communication with the first conductive electrode and the second conductive electrode, wherein the first conductive electrode is in ionic communication with the carrier, wherein the oxidizing agent is generated by electric current passing from the first conductive electrode through the carrier, and wherein the carrier is in communication with the barrier membrane contacting surface.

Claims

1. A method of treating a skin condition in skin, said method comprising applying to said skin a device having a barrier membrane contacting surface that administers an oxidizing agent to said skin, wherein said device comprises:

a power source;

a first conductive electrode, wherein said first conductive electrode is an inert anode;

a second conductive electrode, wherein said second conductive electrode is a cathode; and

a carrier comprising water;

wherein said power source is in electric communication with said first conductive electrode and said second conductive electrode, wherein said first conductive electrode is in ionic communication with said carrier, wherein said oxidizing agent is generated by electric current passing from the first conductive electrode through said carrier, wherein said carrier is in communication with said barrier membrane contacting surface, and wherein said second conductive electrode is in ionic communication with said carrier and wherein said device is adapted to be affixed to said skin and to deliver electric current from said first conductive electrode, through said carrier, through said skin, and through said carrier to said second conductive electrode.

2. A method of claim 1, wherein said second conductive electrode is a reactive electrode.

3. A method of claim 2, said oxidizing agent is nascent oxygen.

4. A method of claim 1, wherein said oxidizing agent is nascent oxygen.

5. A method of claim 1, wherein said device comprises a housing and wherein said first conductive electrode, said second conductive electrode, and said carrier are within said housing.

6. A method of claim 1, wherein said carrier is a semi-solid.

7. A method of claim 1, wherein said skin condition is acne or rosacea.

8. A method of claim 1, wherein said carrier further comprises an active agent selected from the group consisting of salicylic acid, benzoyl peroxide, resorcinol, a retinoid, and sulfur.

9. A device of claim 1, wherein said power source produces conventional direct current and wherein said device is adapted to be affixed to said skin and to deliver said electric current from said power source and said oxidizing agent through said barrier membrane contacting surface to said skin.

10. A method of administering an oxidizing agent to a barrier membrane, said method comprising applying to said membrane a device having a barrier membrane contacting surface that administers said oxidizing agent to said barrier membrane, wherein said device comprises:

a power source;

a first conductive electrode, wherein said first conductive electrode is an inert anode;

a second conductive electrode, wherein said second conductive electrode is a cathode; and

a carrier comprising water;

wherein said power source is in electric communication with said first conductive electrode and said second conductive electrode, wherein said first conductive electrode is in ionic communication with said carrier, wherein said oxidizing agent is generated by electric current passing from the first conductive electrode through said carrier, and wherein said carrier is in communication with said barrier membrane contacting surface, and wherein said second conductive electrode is in ionic communication with said carrier and wherein said device is adapted to be affixed to said barrier membrane and to deliver electric current from said first conductive electrode, through said carrier, through said barrier membrane, and through said carrier to said second conductive electrode.

11. A method of claim 10, wherein said second conductive electrode is a reactive electrode.

12. A method of claim 11, wherein said oxidizing agent is nascent oxygen.

13. A method of claim 10, wherein said oxidizing agent is nascent oxygen.

14. A method of claim 10, wherein said device comprises a housing and wherein said first conductive electrode, said second conductive electrode, and said carrier are within said housing.

15. A method of claim 10, wherein said carrier is a semi-solid.

16. A method of claim 10, wherein said carrier further comprises an active agent selected from the group consisting of salicylic acid, benzoyl peroxide, resorcinol, a retinoid, and sulfur.

17. A method of claim 10, wherein said active agent is selected from the group consisting of an anti-acne agent, an anti-rosacea agent, an anti-aging agent, a depigmentation agent, an antibiotic agent, an antifungal agent, an anti-psoriatic agent, an antimicrobial agent, an anti-viral agent, and an anti-inflammatory agent.

18. A method of claim 10, wherein said power source produces conventional direct current and wherein said device delivers said electric current from said power source and said oxidizing agent through said barrier membrane contacting surface to said barrier membrane.