Baroreflex modulation to gradually decrease blood pressure
First Claim
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1. A baroreflex stimulator, including:
- a pulse generator to provide a baroreflex stimulation signal through an electrode for a baroreflex therapy;
a blood pressure sensor to provide a sensed blood pressure signal;
a memory to store a target blood pressure, a time duration that defines a time period beginning with an event trigger for sensed blood pressure to reach the target blood pressure, and a programmed algorithm for determining a rate of change for progressively increasing a level of the baroreflex therapy using the sensed blood pressure signal, the target blood pressure, and the time duration, wherein the programmed algorithm is adapted to determine the rate of change to progressively decrease sensed blood pressure to the target blood pressure by an end of the time period; and
a modulator operatively connected to the pulse generator, the blood pressure sensor and the memory to implement the programmed algorithm in the memory to modulate the baroreflex stimulation signal to progressively increase the level of the baroreflex stimulation therapy by the rate of change determined by the algorithm to progressively lower sensed blood pressure to the target pressure by the end of the time period.
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Abstract
An aspect of the present subject matter relates to a baroreflex stimulator. An embodiment of the stimulator includes a pulse generator to provide a baroreflex stimulation signal through an electrode, and a modulator. The modulator modulates the baroreflex stimulation signal to increase the baroreflex stimulation therapy by a predetermined rate of change to lower systemic blood pressure to a target pressure. Other aspects are provided herein.
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Citations
50 Claims
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1. A baroreflex stimulator, including:
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a pulse generator to provide a baroreflex stimulation signal through an electrode for a baroreflex therapy; a blood pressure sensor to provide a sensed blood pressure signal; a memory to store a target blood pressure, a time duration that defines a time period beginning with an event trigger for sensed blood pressure to reach the target blood pressure, and a programmed algorithm for determining a rate of change for progressively increasing a level of the baroreflex therapy using the sensed blood pressure signal, the target blood pressure, and the time duration, wherein the programmed algorithm is adapted to determine the rate of change to progressively decrease sensed blood pressure to the target blood pressure by an end of the time period; and a modulator operatively connected to the pulse generator, the blood pressure sensor and the memory to implement the programmed algorithm in the memory to modulate the baroreflex stimulation signal to progressively increase the level of the baroreflex stimulation therapy by the rate of change determined by the algorithm to progressively lower sensed blood pressure to the target pressure by the end of the time period. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 47)
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13. An implantable medical system, comprising:
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means for sensing blood pressure; means for applying a baroreflex therapy, including means for applying baroreflex stimulation to a pressoreceptive region to lower systemic blood pressure; and means for progressively increasing a level of the baroreflex stimulation therapy by a rate of change over a time period pre-programmed into the implantable medical system to progressively lower sensed blood pressure to a target pressure by an end of the time period as the level of the baroreflex therapy is progressively increased by the rate of change, wherein the means for progressively increasing the level includes means for determining the rate of change to reach the target pressure by the end of the time period using the time period, sensed blood pressure and the target pressure to cause the system blood pressure to be progressively lowered during the time period. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 48)
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27. A method for operating an implantable medical device, comprising:
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sensing a blood pressure; applying a baroreflex stimulation therapy using a baroreflex stimulator in the implantable medical device; implementing an algorithm programmed in the implantable medical device to determine a rate of change for increasing a level of the baroreflex therapy using sensed blood pressure, a programmed target pressure, and a programmed time duration that defines a time period beginning with an event trigger for sensed blood pressure to reach the target blood pressure; and increasing a level of the baroreflex stimulation therapy by the rate of change determined by the algorithm to progressively lower sensed blood pressure to the target pressure as the level of the baroreflex therapy is progressively increased during the time period by the determined rate of change. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 44, 45, 46, 49)
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36. A method, comprising:
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sensing a blood pressure; applying a baroreflex stimulation therapy to a baroreceptor site using a lead extending into the pulmonary artery; implementing an algorithm programmed in an implantable medical device to determine a rate of change for increasing a level of the baroreflex therapy using sensed blood pressure, a target pressure programmed in the implantable medical device, and a time duration programmed in the implantable medical device that defines a time period beginning with an event trigger for sensed blood pressure to reach the target blood pressure; and implementing a process to increase the baroreflex stimulation therapy by the rate of change determined by the algorithm to progressively lower sensed blood pressure to the target pressure at an end of the time period. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 50)
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Specification