Methods for detecting and monitoring sleep disordered breathing using an implantable medical device

• US 7,488,291 B2
• Filed: 09/28/2005
• Issued: 02/10/2009
• Est. Priority Date: 09/28/2005
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Cho, Yong K., Bennett, Tommy D., Kjellstrom, Barbro M.
• Primary Examiner(s): Marmor, II; Charles A
• Assistant Examiner(s): JANG, CHRISTIAN YONGKYUN
• Application Number:
  US11/237,354
• Publication Number:
  US 20070073171A1
• Time in Patent Office: 1,231 Days
• Field of Search: 600/486
• US Class Current: 600/486
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/283 Invasive
• CPC Class Codes: A61B 5/4818 Sleep apnoea
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

A method of identifying sleep disordered breathing (SDB) in a patient includes monitoring a hemodynamic pressure, deriving high, middle, and low values representative of the distribution of the hemodynamic pressure over a storage interval, measuring a ratio of a lower range to a full range of the hemodynamic pressure based on the derived high, middle, and low values, and using the ratio to determine whether the patient has experienced an SDB episode. Certain embodiments of the invention compare the ratio to a threshold value to identify the occurrence of an SDB episode, while other embodiments of the invention identify the occurrence of an SDB episode by monitoring for a simultaneous increase in both the ratio and the full range of the hemodynamic pressure. In certain other embodiments of the invention, activity level and/or duration criteria may be employed to confirm the occurrence of an SDB episode detected using the ratio.

Claims

1. A method of identifying sleep disordered breathing (SDB) episodes in a patient, the method comprising:

measuring a hemodynamic pressure of the patient;

periodically deriving statistical information about the measured hemodynamic pressure at storage intervals, the statistical information including a high value, a middle value, and a low value representative of the distribution of the hemodynamic pressure over each storage interval;

determining a ratio of a lower range to a full range of the hemodynamic pressure, the lower range being equal to a difference between the middle value and the low value, and the full range being equal to the difference between the high value and the low value; and

determining whether the patient has experienced an SDB episode based upon the ratio.

2. The method of claim 1, wherein the hemodynamic pressure is right ventricular diastolic pressure.

3. The method of claim 1, wherein the high, middle and low values correspond to predetermined percentile values of the hemodynamic pressure derived over each storage interval.

4. The method of claim 3, wherein the predetermined percentile values of the hemodynamic pressure are the 94.sup.th, 50.sup.th, and 6.sup.th percentile value over each storage interval.

5. The method of claim 1 wherein the middle value is selected from the group consisting of a median, mean, and mode of the hemodynamic pressure derived over each storage interval.

6. The method of claim 1 wherein determining whether the patient has experienced SDB episodes comprises:

comparing the ratio to a predetermined ratio threshold and identifying when the ratio exceeds the predetermined ratio threshold.

7. The method of claim 6 wherein the predetermined ratio threshold is greater than 0.5.

8. The method of claim 6 wherein determining whether the patient has experienced SDB episodes further comprises:

monitoring an activity level of the patient and identifying when the activity level exceeds a predetermined activity threshold.

9. The method of claim 8 wherein the activity level of the patient is obtained using one of a piezoelectric sensor and an accelerometer.

10. The method of claim 6 wherein the step of using the ratio to determine whether the patient has SDB episodes further comprises:

determining whether the ratio exceeds the predetermined ratio threshold for a specified duration.

11. The method of claim 10 wherein the specified duration comprises an interval of time.

12. The method of claim 10 wherein the specified duration comprises at least X out of Y storage intervals.

13. The method of claim 1 wherein determining whether the patient has SDB episodes comprises:

identifying when both the ratio and the full range of the hemodynamic pressure are increasing.

14. The method of claim 13 wherein an increase in the ratio and full range of the hemodynamic pressure is determined by comparing a short-term average of the hemodynamic pressure to a long-term average of the hemodynamic pressure.

15. The method of claim 13 wherein an increase in the ratio and full range of the hemodynamic pressure is determined by computing a derivative of the ratio and full range.