Injector with bypass channel

• US 7,488,308 B2
• Filed: 08/13/2004
• Issued: 02/10/2009
• Est. Priority Date: 02/15/2002
• Status: Expired due to Fees

• Current Assignee: Antares Pharma Incorporated
• Original Assignee: Antares Pharma Incorporated
• Inventors: Lesch, Paul R. Jr.
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): Bouchelle; Laura A
• Application Number:
  US10/917,419
• Publication Number:
  US 20050020984A1
• Time in Patent Office: 1,642 Days
• Field of Search: 604235-238, 604/268, 604/110, 604/187
• US Class Current: 604/236
• CPC Class Codes: A61M 2005/2013 triggering of discharging means by contact of injector with patient body
• CPC Class Codes: A61M 2005/2462 by displacing occluding plugs
• CPC Class Codes: A61M 2005/287 by displacing occluding plugs
• CPC Class Codes: A61M 2005/3103 Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
• CPC Class Codes: A61M 2005/3132 having flow passages for injection agents at the distal end of the barrel to bypass a sealing stopper after its displacement to this end due to internal pressure increase
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/2459 upon internal pressure increase, e.g. pierced or burst A61M5/2429 takes precedence
• CPC Class Codes: A61M 5/286 upon internal pressure increase, e.g. pierced or burst A61M5/283 takes precedence
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: A61M 5/326 Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user

Abstract

An injector with a substance container defining a substance chamber configured for containing a substance to be injected, and an injection conduit configured for injecting the substance into a patient. A driver is associated with the substance chamber for driving the substance through the injection conduit. The injector also has a channel member defining a channel that has an open configuration in which the channel fluidly communicates the substance container to the injection conduit for the injection of the substance. The channel also has a closed configuration for blocking flow of any substance in the substance container therethrough to the injection conduit for inhibiting or preventing contact with the injection conduit prior to injection.

Claims

1. An injector, comprising:

a substance container defining a substance chamber configured for containing a substance to be injected;

an injection conduit configured for injecting the substance into a patient;

a driver associated with the substance chamber for driving the substance through the injection conduit;

a channel member having an interior surface that defines an internal passageway open to the substance chamber, the channel member defining a channel that has a first end open towards the internal passageway for receiving the substance from the chamber and a second end open towards the injection conduit, the channel extending radially exterior to a portion of the interior surface and internal passageway between the first and second ends for bypassing the internal passageway to fluidly communicate the substance container to the injection conduit from the first end to the second end for injecting the substance;

a blocking stopper having a closed position for blocking flow of any substance from the substance container through the channel to the injection conduit, the blocking stopper being movable within the internal passageway with respect to the channel ends to an open position for unblocking the flow of the substance from the chamber to the first end, through the channel around the blocking stopper to the second end, and to the injection conduit for injecting the substance, wherein the channel member comprises a guide protruding inwardly adjacent the groove to the interior surface for defining a circumferential side of the channel and for guiding and positioning the stopper in the open position;

a firing mechanism operably associated with the driver and operable by the user to cause the driver to drive the substance sufficiently to move the blocking stopper to the open position and also to inject the substance into the patient; and

an energy source configured for driving the driver to both move the blocking stopper to the open position and inject the substance into the patient.

2. The injector of claim 1, wherein the firing mechanism is operable by the user to cause the driver to drive the substance sufficiently to move the blocking stopper to the open position and also to inject the substance into the patient by a single action of the user on the firing mechanism.

3. The injector of claim 1, wherein the injector is assembled such that actuation of the firing mechanism to cause the substance to be injected also causes the blocking stopper to move to the open position.

4. The injector of claim 1, wherein the injector is fully assembled and in condition for firing the substance with the blocking stopper in the closed position.

5. The injector of claim 1, wherein substantially all of the substance to be injected is disposed between the driver and the blocking stopper.

6. The injector of claim 5, wherein the driver comprises a plunger, and both the plunger and the blocking stopper are slideable within the container.

7. The injector of claim 1, wherein the substance container has a distal end disposed adjacent the injection conduit, and the channel member is disposed in or adjacent the distal end.

8. The injector of claim 1, wherein the injection conduit comprises a needle-free jet nozzle configured for firing the substance in a fluid jet sufficient to penetrate tissue of the patient.

9. The injector of claim 1, wherein the injection conduit comprises a needle, and the channel member comprises a needle hub supporting the needle and attached to the substance container.

10. The injector of claim 1, wherein the container comprises a cartridge that defines a locking recess, the injector further comprising:

a resilient cartridge-gripping portion comprising a plurality of resilient fingers that are received in the locking recess and thereby engaged with the cartridge to retain the cartridge sealed and in fluid communication with the injection conduit during injection; and

a locking portion disposed around the fingers to retain the cartridge-gripping portion in the engagement with the cartridge to withstand pressures within the cartridge during injection.

11. The injector of claim 1, wherein the substance container comprises a shoulder to stop movement of the driver towards the blocking stopper prior to moving into contact herewith.

22. The injector of claim 9, wherein the injector is a jet injector, and the energy source and needle are configured for jet injecting the substance.

12. An injector, comprising:

a substance container defining a substance chamber configured for containing a substance to be injected;

an injection conduit configured for injecting the substance into a patient;

a driver associated with the substance chamber for driving the substance through the injection conduit;

a channel member having an interior surface that defines an internal passageway open to the substance chamber, having a channel region defining a channel that has a first end open towards the internal passageway for receiving the substance from the chamber and a second end open towards the injection conduit, channel extending radially exterior to the interior surface and internal passageway at a location between the first end and second ends for bypassing the internal passageway in an open configuration to fluidly communicate the substance container to the injection conduit from the first end to the second end for injecting the substance;

a blocking stopper having a closed position downstream of any substance to be injected that is contained in the container and being movable with respect to the channel between the closed position and an open position, in the closed position the stopper being disposed at least partially outside the channel region for blocking flow of the substance between the chamber and the first end of the channel for sealing and retaining the substance within the chamber, and in the open position the stopper being disposed within the channel region between the first and second ends for cooperating with the channel to allow the substance to flow from the chamber to the first end, through the channel around and past the blocking stopper to the second end, and to the injection conduit, wherein the channel member comprises a guide protruding inwardly adjacent the groove to the interior surface for defining a circumferential side of the channel and for guiding and positioning the stopper in the open position; and

a firing mechanism operably associated with the driver and operable by the user to cause the driver to drive the substance sufficiently to move the blocking stopper to the open position and also to inject the substance into the patient.

13. The injector of claim 12, wherein the substance container has a distal end adjacent the injection conduit, and the stopper is disposed in the distal end of the container in the closed position and proximally from the first end of the channel, the open position of the stopper being disposed distally from the closed position and closer to the injection conduit than the closed position, and the second end of the channel is located distally from the first end.

14. The injector of claim 13, wherein the container comprises a cartridge that includes said distal end, and the channel member comprises a hub of separate construction than the cartridge and attached thereto, the hub including the injection conduit, the stopper being disposed in the distal end in the closed position to seal the cartridge and being disposed outside the cartridge but within the hub in the open position.

15. The injector of claim 12, wherein the channel comprises a groove in the channel member in the channel region.

16. The injector of claim 12, wherein:

the injection conduit comprises a needle having an upstream opening for receiving the substance during injection thereof; and

the blocking stopper is configured to move to the open position without the needle piercing the stopper.

17. The injector of claim 12, wherein the second side of the blocking stopper is configured for receiving the needle in the open position, the stopper defining an internal groove configured and dimensioned for allowing the substance to flow therethrough to the upstream opening of the needle in the open position.

18. The injector of claim 12, wherein the channel member comprises a narrow portion of the internal passageway that is narrower than the blocking stopper for blocking movement of the blocking stopper past the open position, wherein the second end of the channel is disposed in the narrow portion.

19. The injector of claim 12, wherein the stopper has a first side facing inside the cartridge and a second side facing the outside the cartridge, in the closed position, the stopper closing the channel for sealing and retaining the substance within the cartridge adjacent the first side of the stopper such that the second side of the stopper is free from contact with any of the substance from the cartridge.

20. The injector of claim 12, wherein the pressure within the cartridge during injection is about between 50 psi and 3000 psi.

21. The injector of claim 12, wherein the blocking stopper is movable in a longitudinal direction between the closed and open positions, and the channel extends laterally about the blocking stopper with respect to the longitudinal direction.

23. The injector of claim 12, wherein the channel comprises a plurality of channels, and the guide comprises a plurality of guides that are disposed between the channels for defining the channels and retaining the blocking stopper within the internal passageway.

24. The injector of claim 23, wherein the guides and channels are disposed circumferentially about the blocking stopper in the open position, such that the interior surface on the guides define the internal passageway of smaller width than a larger width measured to an outwardly disposed walls of the channels, wherein the blocking stopper has a width selected to be received within the internal passageway but narrower than said larger width so that the channels extend radially around the blocking stopper in the open position in channel region.

25. The injector of claim 12, wherein the injector is a jet injector which further comprises an energy source configured for driving the driver to both move the blocking stopper to the open position and inject the substance into the patient, and wherein the firing mechanism is operably associated with the energy source and operable by the user to cause the energy source to drive the driver for driving the substance sufficiently to move the blocking stopper to the open position and also to jet inject the substance into the patient.

26. The injector of claim 25, wherein the firing mechanism comprises a trigger mechanism activatable by the user, wherein a single activation of the trigger activates the energy source for moving the blocking stopper to the open position and also to inject the substance into the patient.

27. The injector of claim 25, wherein the injector is configured to prevent access to the driver for preventing refilling of the injector once the energy source is operated to inject the substance.

28. The injector of claim 12, wherein the blocking stopper has a blocking portion that seals the chamber in the closed position, the blocking portion having a longitudinal length that is shorter than a length of the channel between the first and second ends to enable the channel allow the substance to flow around and radially exterior to the blocking stopper in the open position.

29. The injector of claim 12, wherein the second end is open to the internal passageway.

30. The injector of claim 15, wherein the groove is open to the internal passageway along its length.