Medical devices

• US 7,488,343 B2
• Filed: 09/16/2003
• Issued: 02/10/2009
• Est. Priority Date: 09/16/2003
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: O'Brien, Barry, Nolan, Robert, Brown, Brian
• Primary Examiner(s): Truong; Kevin T
• Assistant Examiner(s): NGUYEN, VI X
• Application Number:
  US10/664,679
• Publication Number:
  US 20050060021A1
• Time in Patent Office: 1,974 Days
• Field of Search: 606/108, 623/1.11, 623/115, 623/1.44
• US Class Current: 623/1.15
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61F 2250/0087 colour-coded
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 31/022 Metals or alloys
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: Y10T 428/24802 Discontinuous or differential coating, impregnation or bond [e.g., artwork, printing, retouched photograph, etc.]

Abstract

Medical devices, particularly stents, suitable for drug delivery and including a porous structure and/or colors are disclosed.

Claims

1. A stent device comprising:

a generally tubular member, the member including a porous structure comprising an oxide of titanium, niobium, tantalum, or an alloy thereof, the porous structure defined by a plurality of hollow post-shaped elements, the hollow post-shaped elements separated by a void region therebetween and each hollow post-shaped element defining an internal volume adapted to contain a therapeutic agent, wherein the generally tubular member has a longitudinal axis and the generally hollow post-shaped elements have a longitudinal axis generally perpendicular to the longitudinal axis of the generally tubular member.

2. The device of claim 1, wherein the porous structure is of an oxide of titanium.

3. The device of claim 1, wherein the generally tubular member comprises a therapeutic agent contained in the internal volumes, the void region, or a combination thereof.

4. The device of claim 3, wherein the therapeutic agent is selected from an antithrombogenic, antioxidant, anti-inflammatory, antiproliferative, or antibiotic.

5. The device of claim 3, wherein the therapeutic agent is selected from a drug, cell, or genetic material.

6. The device of claim 1, wherein the generally tubular member includes a layer of titanium, niobium, tantalum, or an alloy thereof, that has a thickness between about 50 nm and about 500 nm.

7. The device of claim 6, wherein the porous structure is over said layer.

8. The device of claim 1, wherein the post-shaped elements have inner diameters of about 5 nm to about 200 nm.

9. The device of claim 8, wherein the post-shaped elements have inner diameters of about 70 nm to about 100 nm.

10. The device of claim 9, wherein the post-shaped elements have a post height of about 100 nm to about 200 nm.

11. The device of claim 1, wherein the porous structure is on an outer surface of the generally tubular member.

12. The device of claim 1, wherein the generally tubular member comprises titanium, niobium, tantalum, or an alloy thereof.

13. The device of claim 1, wherein said titanium, niobium, tantalum, or alloy thereof is a layer on a different metal.

14. The device of claim 13, wherein the different metal is about 90% or more of the thickness of the tubular member.

15. The device of claim 1, wherein the generally tubular member comprises stainless steel, nitinol, or a cobalt-based alloy.

16. The device of claim 1, wherein the porous structure includes a polymer.

17. The device of claim 16, wherein the polymer is a coating over the porous structure.

18. The device of claim 17, wherein the coating is a diffusion or protective layer.

19. The device of claim 17, wherein the coating is biodegradable.

20. The device of claim 16, wherein the polymer includes a therapeutic agent.

21. The device of claim 1, wherein the porous structure includes a colorant.

22. The device of claim 1, wherein the device has a color corresponding to light having a wavelength between about 370 nm and about 750 nm.

23. The device of claim 22, wherein the color corresponds to light having a wavelength of about 420 nm, about 470 nm, about 530 nm, about 580 nm, about 620 nm, or about 700 nm.

24. The device of claim 1, wherein the hollow post-shaped elements are generally tubular.

25. The device of claim 1, wherein the porous structure has a post-shaped element density of 10 to 300 post-shaped elements per square micron.

26. The device of claim 1, wherein the porous structure acts as a grating that preferentially reflects light having a wavelength between 370 nm and 750 nm.

27. The device of claim 1, wherein the hollow post-shaped elements comprise a closed end.

28. A stent device comprising:

a generally tubular member, the member including a porous structure defined by an plurality of hollow post-shaped elements, the hollow post-shaped elements separated by a void region and each hollow post-shaped element defining an internal volume adapted to contain a therapeutic agent, wherein the generally tubular member has a longitudinal axis and the generally hollow post-shaped elements have a longitudinal axis generally perpendicular to the longitudinal axis of the generally tubular member.

29. The device of claim 28, wherein the generally tubular member includes a therapeutic agent contained in the internal volumes, the void region, or a combination thereof.

30. The device of claim 29, wherein the therapeutic agent is selected from an antithrombogenic, antioxidant, anti-inflammatory, antiproliferative, or antibiotic.

31. The device of claim 29, wherein the therapeutic agent is selected from a drug, cell, or genetic material.

32. The device of claim 28, wherein the post-shaped elements comprise a porous metal oxide.

33. The device of claim 32, wherein the porous metal oxide has a thickness between about 50 nm and about 500 nm.

34. The device of claim 32, wherein the porous metal oxide is on a surface of the generally tubular member.

35. The device of claim 28, wherein the post-shaped elements have inner diameters between about 5 nm and about 200 nm.

36. The device of claim 28, wherein the hollow post-shaped elements are generally tubular.

37. The device of claim 28, wherein the porous structure has a post-shaped element density of 10 to 300 post-shaped elements per square micron.

38. The device of claim 28, wherein the porous structure acts as a grating that preferentially reflects light having a wavelength between 370 nm and 750 nm.

39. The device of claim 28, wherein the hollow post-shaped elements comprise a closed end.