Enantiomerically pure beta agonists, process for the manufacture thereof, and use thereof as medicaments
First Claim
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1. R-6-Hydroxy-8-{1-hydroxy-2-[2-(4-methoxyphenyl)-1,1-dimethylethylamino]ethyl}-4H-benzo[1,4]oxazin-3-one hydrochloride.
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Abstract
Enantiomerically pure compounds of general formula 1
wherein the groups R1, R2, R3, R4, and X− may have the meanings given in the claims and in the specification, processes for preparing them and the use thereof as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.
75 Citations
27 Claims
- 1. R-6-Hydroxy-8-{1-hydroxy-2-[2-(4-methoxyphenyl)-1,1-dimethylethylamino]ethyl}-4H-benzo[1,4]oxazin-3-one hydrochloride.
- 3. R-8-{2-[2-(2,4-Difluorophenyl)-1,1-dimethylethylamino]-1-hydroxyethyl}-6-hydroxy-4H-benzo[1,4]oxazin-3-one hydrochloride.
- 5. R-8-{2-[2-(3,5-Difluorophenyl)-1,1-dimethylethylamino]-1-hydroxyethyl}-6-hydroxy-4H-benzo[1,4]oxazin-3-one hydrochloride.
- 7. R-8-{2-[2-(4-Ethoxyphenyl)-1,1-dimethylethylamino]-1-hydroxyethyl}-6-hydroxy-4H-benzo[1,4]oxazin-3-one hydrochloride.
- 9. R-8-{2-[2-(4-Fluorophenyl)-1,1-dimethylethylamino]-1-hydroxyethyl}-6-hydroxy-4H-benzo[1,4]oxazin-3-one hydrochloride.
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13. R-6-Hydroxy-8-{1-hydroxy-2-[2-(4-methoxyphenyl)-1,1-dimethylethylamino]ethyl}-4H-benzo [1,4]oxazin-3-one in the form of an acid addition salt with an acid HX, wherein X−
- denotes an anion with a single negative charge.
- View Dependent Claims (14, 15)
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16. R-8-{2-[2-(2,4-Difluorophenyl)-1,1-dimethylethylamino]-1-hydroxyethyl}-6-hydroxy-4H-benzo [1,4]oxazin-3-one in the form of an acid addition salt with an acid HX, wherein X−
- denotes an anion with a single negative charge.
- View Dependent Claims (17, 18)
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19. R-8-{2-[2-(2,4-Difluorophenyl)-1,1-dimethylethylamino]-1-hydroxyethyl}-6-hydroxy-4H-benzo [1,4]oxazin-3-one in the form of an acid addition salt with an acid HX, wherein X−
- denotes an anion with a single negative charge.
- View Dependent Claims (20, 21)
-
22. R-8-{2-[2-(4-Ethoxyphenyl)-1,1-dimethylethylamino]-1-hydroxyethyl}-6-hydroxy-4H-benzo [1,4]oxazin-3-one in the form of an acid addition salt with an acid HX, wherein X−
- denotes an anion with a single negative charge.
- View Dependent Claims (23, 24)
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25. R-8-{2-[2-(4-Ethoxyphenyl)-1,1-dimethylethylamino]-1-hydroxyethyl}-6-hydroxy-4H-benzo [1,4]oxazin-3-one in the form of an acid addition salt with an acid HX, wherein X−
- denotes an anion with a single negative charge.
- View Dependent Claims (26, 27)
Specification