Multipole ion guide having longitudinally rounded electrodes

• US 7,491,932 B2
• Filed: 06/16/2006
• Issued: 02/17/2009
• Est. Priority Date: 06/16/2006
• Status: Active Grant

• Current Assignee: Thermo Finnigan LLC (Thermo Fisher Scientific Incorporated)
• Original Assignee: Thermo Finnigan LLC (Thermo Fisher Scientific Incorporated)
• Inventors: Thakur, Rohan A., Wouters, Eloy R., Splendore, Maurizio
• Primary Examiner(s): Berman; Jack I
• Assistant Examiner(s): SMITH, JOHNNIE L
• Application Number:
  US11/454,263
• Publication Number:
  US 20080067365A1
• Time in Patent Office: 977 Days
• Field of Search: 250/292, 250/283
• US Class Current: 250/292
• CPC Class Codes: H01J 49/063 Multipole ion guides, e.g. quadrupoles, hexapoles

Abstract

An ion guide having a plurality of spheroidal or similarly shaped electrodes is disclosed. The electrodes are arranged in pairs about a central ion flow axis, and an RF voltage is applied in a prescribed phase relation to create an electric field that focuses and radially confines an ion beam. A defocusing effect associated with the electrode shape may be reduced by placement of a separate skirt electrode immediately downstream in the ion path, or by forming the electrodes in a composite structure, whereby the trailing portion of the electrode is fabricated from or coated with an insulative material.

Claims

1. An ion guide comprising:

a plurality of electrodes arranged around a central ion flow axis, each of the plurality of electrodes having a continuously rounded inner surface in a longitudinal plane extending through the ion flow axis, the plurality of electrodes being arranged into a plurality of electrode pairs, each electrode pair having two electrodes opposed across the central ion flow axis; and

a radio-frequency (RF) voltage source for applying an RF voltage to the plurality of electrodes.

2. The ion guide of claim 1, wherein each of the plurality of electrodes has a spheroidal shape.

3. The ion guide of claim 1, wherein each of the plurality of electrodes has an ellipsoidal shape.

4. The ion guide of claim 1, wherein the plurality of electrodes includes four electrodes arranged in two electrode pairs.

5. The ion guide of claim 1, further comprising a skirt electrode positioned immediately downstream in the ion path from the plurality of electrodes.

6. The ion guide of claim 1, wherein each electrode includes a conductive leading portion positioned proximal to an entrance of the ion guide and an insulative portion positioned proximal to an exit of the ion guide.

7. The ion guide of claim 1, wherein the plurality of electrodes are arranged in radial symmetry about the central ion flow axis.

8. The ion guide of claim 1, wherein the plurality of electrodes includes six electrodes arranged in three pairs of opposed electrodes.

9. The ion guide of claim 1, wherein the plurality of electrodes includes eight electrodes arranged in four pairs of opposed electrodes.

10. An inlet section for a mass spectrometer, comprising:

an ion source configured to produce ions within an ion chamber, the ions having an ion path; and

an ion guide positioned downstream of the ion source in the ion path, the ion guide including a plurality of electrodes arranged around a central ion flow axis, each of the plurality of electrodes having a continuously rounded inner surface in a longitudinal plane extending through the ion flow axis, the plurality of electrodes being arranged into a plurality of electrode pairs, each electrode pair having two electrodes opposed across the central ion flow axis; and

a radio-frequency (RF) voltage source for applying an RF voltage to the plurality of electrodes.

11. The inlet section of claim 10, wherein each of the plurality of electrodes has a spheroidal shape.

12. The inlet section of claim 10, wherein each of the plurality of electrodes has an ellipsoidal shape.

13. The inlet section of claim 10, wherein the plurality of electrodes includes four electrodes arranged in two electrode pairs.

14. The inlet section of claim 10, further comprising a skirt electrode positioned immediately downstream in the ion path from the ion guide.

15. The inlet section of claim 10, wherein each electrode includes a conductive leading portion positioned proximal to an entrance of the ion guide and an insulative portion positioned proximal to an exit of the ion guide.

16. The inlet section of claim 10, wherein the plurality of electrodes are arranged in radial symmetry about the central ion flow axis.

17. The inlet section of claim 10, further comprising an ion transfer tube positioned upstream in the ion path of the ion guide.

18. The inlet section of claim 10, further comprising a skimmer positioned upstream in the ion path of the ion guide.

19. The inlet section of claim 10, further comprising a mass analyzer positioned downstream in the ion path of the ion guide.