Methods and apparatus for application of micro-mechanical forces to tissues
First Claim
1. A therapeutic device for promoting tissue growth, said device comprising:
- a variable composition matrix for application to the tissue, said matrix having a plurality of pores;
a compliant biodegradable tube wherein said tube is coated with ECM proteins and configured for inflation; and
a stiff biodegradable wire, wherein said wire is coiled around an external wall of said tube;
such that said tube when inflated protrudes through the wire so as to exert micro-mechanical forces on the tissue.
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Abstract
Methods and devices for transmitting micromechanical forces locally to induce surface convolutions into tissues on the millimeter to micron scale for promoting wound healing are presented. These convolutions induce a moderate stretching of individual cells, stimulating cellular proliferation and elaboration of natural growth factors without increasing the size of the wound. Micromechanical forces can be applied directly to tissue, through biomolecules or the extracellular matrix. This invention can be used with biosensors, biodegradable materials and drug delivery systems. This invention will also be useful in pre-conditioned tissue-engineering constructs in vitro. Application of this invention will shorten healing times for wounds and reduce the need for invasive surgery.
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Citations
5 Claims
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1. A therapeutic device for promoting tissue growth, said device comprising:
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a variable composition matrix for application to the tissue, said matrix having a plurality of pores; a compliant biodegradable tube wherein said tube is coated with ECM proteins and configured for inflation; and a stiff biodegradable wire, wherein said wire is coiled around an external wall of said tube;
such that said tube when inflated protrudes through the wire so as to exert micro-mechanical forces on the tissue. - View Dependent Claims (2)
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3. A method for promoting tissue growth, said method comprising the steps of
a. providing a therapeutic device comprising a variable composition matrix for application to the tissue, said matrix having a plurality of pores; - a compliant biodegradable tube wherein said tube is coated with ECM proteins and configured for inflation; and
a stiff biodegradable wire, wherein said wire is coiled around an external wail of said tube;
such that said tube when inflated protrudes through the wire so as to exert micro-mechanical forces on the tissue,b. applying said matrix adjacent to the tissue; and c. delivering micro-mechanical forces to the tissue through said variable composition matrix. - View Dependent Claims (4, 5)
- a compliant biodegradable tube wherein said tube is coated with ECM proteins and configured for inflation; and
Specification