Apparatus and method for application of a pharmaceutical to the tympanic membrane for photodynamic laser myringotomy
First Claim
1. An apparatus for application of a pharmaceutical and performing a selective photodynamic laser myringotomy, the apparatus comprising:
- the pharmaceutical being a single dose of an otologic formulation of mitomycin-C, the single dose of mitomycin-C having a predetermined specific color; and
,a laser that is specifically tuned to emit a laser beam having a wavelength that is absorbed at a location defined by the specific color of the single dose of mitomycin-C.
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Accused Products
Abstract
A packaged kit for performing a photodynamic laser myringotomy includes a plurality of ear needles having different shaped absorbent applicators on distal ends of the needles, a vial of a single dose of an otologic formulation of mitomycin-C, a diluent carrier containing sterilized water, and a syringe. The component parts of the kit are used together to reconstitute the contents of the vial with the water in the diluent carrier, and then draw the reconstituted drug into the syringe. A selected one of the plurality of ear needles is then communicated with the syringe. The syringe and needle are then used to inject the reconstituted drug into the absorbent pad at the end of the needle, and the absorbent pad containing the drug is used to apply the drug to the tympanic membrane. The application of the drug to the tympanic membrane prepares the membrane for a myringotomy procedure, and in particular, a photodynamic laser myringotomy.
26 Citations
19 Claims
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1. An apparatus for application of a pharmaceutical and performing a selective photodynamic laser myringotomy, the apparatus comprising:
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the pharmaceutical being a single dose of an otologic formulation of mitomycin-C, the single dose of mitomycin-C having a predetermined specific color; and
,a laser that is specifically tuned to emit a laser beam having a wavelength that is absorbed at a location defined by the specific color of the single dose of mitomycin-C. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An apparatus for application of a pharmaceutical comprising:
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the pharmaceutical being a single dose of an otologic formulation of mitomycin-C; the single dose of mitomycin-C having a specific color; an ear needle that is adapted for receiving the single dose of mitomycin-C and delivering the mitomycin-C to a tympanic membrane to remain in situ on the tympanic membrane and cause anti-metabolic activity on the tympanic membrane that is localized and defined by the specific color; and
,a laser that is specifically tuned to emit a laser beam that will ablate tympanic membrane tissue at a location on the tympanic membrane that is defined by the specific color and will not effect adjacent structure of a dissimilar color.
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15. A method for application of a pharmaceutical and performing selective a photodynamic laser myringotomy, the method comprising:
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providing a single dose of an otologic formulation of mitomycin-C;
coloring the single dose of mitomycin-C with a predetermined specific color;applying the single dose of mitomycin-C to interior tissue of an ear canal; and
,ablating the tissue at a location on the tissue to which the mitomycin-C has been applied with a laser beam having a wavelength that is absorbed by the specific color of the mitomycin-C, while being ignored by adjacent structures of a dissimilar color. - View Dependent Claims (16, 17, 18)
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19. A method for application of a pharmaceutical and performing a selective photodynamic laser myringotomy comprising:
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providing a single dose of an otologic formulation of mitomycin-C; applying the single dose of mitomycin-C to interior tissue of an ear canal; giving the mitomycin-C a specific color; applying the mitomycin-C to a tympanic membrane in the ear canal; causing anti-metabolic activity on the tympanic membrane by application of the mitomycin-C at a location on the tympanic membrane that is defined by the color of the mitomycin-C; and
,treating the location on the tympanic membrane by ablating the location with a laser beam specifically tuned to the color of the mitomycin-C.
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Specification