Cytokine receptor zcytor17
First Claim
1. An isolated polypeptide comprising an amino acid sequence having at least 95% sequence identity with amino acid residues 20-732 of SEQ ID NO:
- 2, wherein the polypeptide stimulates inflammation upon binding zcytor17 ligand.
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Abstract
Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
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Citations
11 Claims
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1. An isolated polypeptide comprising an amino acid sequence having at least 95% sequence identity with amino acid residues 20-732 of SEQ ID NO:
- 2, wherein the polypeptide stimulates inflammation upon binding zcytor17 ligand.
- View Dependent Claims (2, 3)
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4. An isolated soluble receptor polypeptide comprising an amino acid sequence having at least 95% sequence identity with amino acid residues 20-519 of SEQ ID NQ:
- 2, wherein the soluble receptor polypeptide reduces zcytor17 ligand induced inflammation.
- View Dependent Claims (5, 6, 7)
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8. A composition comprising:
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an isolated soluble receptor polypeptide comprising an amino acid sequence having at least 95% sequence identity with amino acid residues 20-519 of SEQ ID NO;
2; anda pharmaceutically acceptable vehicle; and wherein the soluble receptor polypeptide reduces zcytor17 ligand induced inflammation. - View Dependent Claims (9, 10, 11)
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Specification