Germicidal method for eradicating or preventing the formation of biofilms
First Claim
Patent Images
1. The method of treating a host diagnosed with one or more biofilms, the biofilms having an outer barrier and an underlying colony of organisms comprises the steps of:
- receiving a host diagnosed with one or more biofilms;
locating a region or location of a resident biofilm;
activating a pressure pulse or acoustic shock wave generating source, the pressure pulse being an acoustic pulse which includes several cycles of positive and negative pressure, wherein the pressure pulse has an amplitude of the positive part of such a cycle should be above 0.1 MPa and the time duration of the pressure pulse is from below a microsecond to about a second, rise times of the positive part of the first pressure cycle in the range of nano-seconds (ns) up to some milli-seconds (ms), the acoustic shock waves being very fast pressure pulses having amplitudes above 0.1 MPa and rise times of the amplitude being below 100'"'"'s of ns, the duration of the shock wave is typically below 1-3 micro-seconds (μ
s) for the positive part of a cycle and typically above some micro-seconds for the negative part of a cycle;
emitting pressure pulses or acoustic shock waves using focused pulses or shock waves at an energy density up to 1.0 mmJ/mm2;
with or without creating cavitation bubbles in the location or region of the resident biofilm, the focused pulses or shock waves having a focal volume or point on the location or region of the resident biofilm or using unfocused pulses or shock waves and away from any localized geometric focal volume or point of the emitted shock waves wherein the emitted shock waves or pressure pulses either have no geometric focal volume or point or have a focal volume or point ahead of the location or region of a resident biofilm or beyond the location or region of a resident biofilm thereby passing the emitted waves or pulses through the location or region of a resident biofilm while avoiding having any localized focal point within the location or region of a resident biofilm wherein the emitted pressure pulses or shock waves are convergent, divergent, planar or near planar and the pressure pulse shock wave generator or source is based on electro-hydraulic, electromagnetic, piezoceramic or ballistic wave generation having an energy density value ranging as low as 0.00001 mJ/mm2 to a high end of below 1.0 mJ/mm2; and
directing the pulses or shock waves to impinge the resident biofilm to destroy, fracture, fragment or otherwise open the outer barrier structure of the resident biofilm.
3 Assignments
0 Petitions
Accused Products
Abstract
A method of treatment for a tissue organ or entire body of a patient prior to or after exposure to a biofilm infection comprises the steps of activating an acoustic shock wave generator or source to emit acoustic shock waves; and subjecting the infected tissue, organ or entire body to the acoustic shock waves stimulating said tissue, organ or body wherein the tissue, organ or body is positioned within a path of the emitted shock waves.
-
Citations
20 Claims
-
1. The method of treating a host diagnosed with one or more biofilms, the biofilms having an outer barrier and an underlying colony of organisms comprises the steps of:
-
receiving a host diagnosed with one or more biofilms; locating a region or location of a resident biofilm; activating a pressure pulse or acoustic shock wave generating source, the pressure pulse being an acoustic pulse which includes several cycles of positive and negative pressure, wherein the pressure pulse has an amplitude of the positive part of such a cycle should be above 0.1 MPa and the time duration of the pressure pulse is from below a microsecond to about a second, rise times of the positive part of the first pressure cycle in the range of nano-seconds (ns) up to some milli-seconds (ms), the acoustic shock waves being very fast pressure pulses having amplitudes above 0.1 MPa and rise times of the amplitude being below 100'"'"'s of ns, the duration of the shock wave is typically below 1-3 micro-seconds (μ
s) for the positive part of a cycle and typically above some micro-seconds for the negative part of a cycle;emitting pressure pulses or acoustic shock waves using focused pulses or shock waves at an energy density up to 1.0 mmJ/mm2;
with or without creating cavitation bubbles in the location or region of the resident biofilm, the focused pulses or shock waves having a focal volume or point on the location or region of the resident biofilm or using unfocused pulses or shock waves and away from any localized geometric focal volume or point of the emitted shock waves wherein the emitted shock waves or pressure pulses either have no geometric focal volume or point or have a focal volume or point ahead of the location or region of a resident biofilm or beyond the location or region of a resident biofilm thereby passing the emitted waves or pulses through the location or region of a resident biofilm while avoiding having any localized focal point within the location or region of a resident biofilm wherein the emitted pressure pulses or shock waves are convergent, divergent, planar or near planar and the pressure pulse shock wave generator or source is based on electro-hydraulic, electromagnetic, piezoceramic or ballistic wave generation having an energy density value ranging as low as 0.00001 mJ/mm2 to a high end of below 1.0 mJ/mm2; anddirecting the pulses or shock waves to impinge the resident biofilm to destroy, fracture, fragment or otherwise open the outer barrier structure of the resident biofilm. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
-
-
15. The method of preventively treating a patient at risk of developing a biofilm and becoming a host;
- comprises the steps of;
identifying an at risk patient with a pathological or degenerative condition susceptible to the generation of a biofilm; treating the at risk patient by; locating the location or region to be treated; activating a pressure pulse or acoustic shock wave generating source, the pressure pulse being an acoustic pulse which includes several cycles of positive and negative pressure, wherein the pressure pulse has an amplitude of the positive part of such a cycle should be above 0.1 MPa and the time duration of the pressure pulse is from below a microsecond to about a second, rise times of the positive part of the first pressure cycle in the range of nano-seconds (ns) up to some milli-seconds (ms), the acoustic shock waves being very fast pressure pulses having amplitudes above 0.1 MPa and rise times of the amplitude being below 100'"'"'s of ns, the duration of the shock wave is typically below 1-3 micro-seconds (μ
s) for the positive part of a cycle and typically above some micro-seconds for the negative part of a cycle; andemitting pressure pulses or acoustic shock waves using focused or unfocused pulses or shock waves at an energy density up to 1.0 mmJ/mm2 and directing the pulses or shock waves to impinge an area of the treatment region or location;
in the absence of a focal point impinging the treatment region or location to stimulate a cellular response in the absence of creating cavitation bubbles in the location or region evidenced by not experiencing the sensation of hemorrhaging caused by the emitted waves or pulses wherein the area of the treatment region or location is away from any localized geometric focal volume or point of the emitted shock waves wherein the emitted shock waves or pressure pulses either have no geometric focal volume or point or have a focal volume or point ahead of the location or region of treatment or beyond the location or region of treatment thereby passing the emitted waves or pulses through the location or region of treatment while avoiding having any localized focal point within the location or region of treatment wherein the emitted pressure pulses or shock waves are convergent, divergent, planar or near planar and the pressure pulse shock wave generator or source is based on electro-hydraulic, electromagnetic, piezoceramic or ballistic wave generation having an energy density value ranging as low as 0.00001 mJ/mm2 to a high end of below 1.0 mJ/mm2. - View Dependent Claims (16, 17, 18, 19, 20)
- comprises the steps of;
Specification
-
- Resources
Litigation Campaign Assessment
Thank you for your request. You will receive a custom alert email when the Litigation Campaign Assessment is available.
×
-
Current AssigneeSoftwave Tissue Regeneration Technologies, LLC
-
Original AssigneeGeneral Patent, LLC (Tissue Regeneration Technologies LLC)
-
InventorsSchaden, Wolfgang, Warlick, John, Schultheiss, Reiner
-
Primary Examiner(s)Casler; Brian
-
Assistant Examiner(s)RAMIREZ, JOHN FERNANDO
-
Application NumberUS11/238,551Publication NumberTime in Patent Office1,251 DaysField of Search600/437, 601/1, 601/2US Class Current601/2CPC Class CodesA61B 17/22004 using mechanical vibrations...A61N 7/00 Ultrasound therapy lithotri...
