High mass throughput particle generation using multiple nozzle spraying
First Claim
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1. An electrospraying method, the method comprising:
- providing a plurality of nozzle structures, wherein each nozzle structure comprises at least one opening defined along a center axis of the nozzle structure and terminating at a dispensing end thereof from which a spray of particles having an electrical charge applied thereto is dispensed, wherein the particles have a nominal diameter of about 1 nanometer to about 2000 nanometers, wherein the dispensing end of each nozzle structure is separated from the dispensing end of adjacent nozzle structures, and further wherein the dispensing end of a first nozzle structure terminates in a first plane orthogonal to the center axis of the nozzle structure and dispensing ends of one or more other nozzle structures terminate in one or more different planes than the first plane;
dispensing the spray of particles from each nozzle structure by creating a nonuniform electrical field between the dispensing ends from which the sprays are established and an electrode electrically isolated from the dispensing ends; and
depositing the particles on a surface to form a coating thereon.
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Abstract
Spraying apparatus and methods that employ multiple nozzle structures for producing multiple sprays of particles, e.g., nanoparticles, for various applications, e.g., pharmaceuticals, are provided. For example, an electrospray dispensing device may include a plurality of nozzle structures, wherein each nozzle structure is separated from adjacent nozzle structures by an internozzle distance. Sprays of particles are established from the nozzle structures by creating a nonuniform electrical field between the nozzle structures and an electrode electrically isolated therefrom.
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Citations
39 Claims
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1. An electrospraying method, the method comprising:
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providing a plurality of nozzle structures, wherein each nozzle structure comprises at least one opening defined along a center axis of the nozzle structure and terminating at a dispensing end thereof from which a spray of particles having an electrical charge applied thereto is dispensed, wherein the particles have a nominal diameter of about 1 nanometer to about 2000 nanometers, wherein the dispensing end of each nozzle structure is separated from the dispensing end of adjacent nozzle structures, and further wherein the dispensing end of a first nozzle structure terminates in a first plane orthogonal to the center axis of the nozzle structure and dispensing ends of one or more other nozzle structures terminate in one or more different planes than the first plane; dispensing the spray of particles from each nozzle structure by creating a nonuniform electrical field between the dispensing ends from which the sprays are established and an electrode electrically isolated from the dispensing ends; and depositing the particles on a surface to form a coating thereon. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. An electrospraying method, the method comprising:
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providing a plurality of nozzle structures, wherein each nozzle structure comprises at least two openings defined along a center axis of the nozzle structure and terminating at a dispensing end thereof from which a spray of particles having an electrical charge applied thereto is dispensed, wherein the at least two openings comprise at least a first and second opening terminating at the dispensing end of each nozzle structure, wherein the dispensing end of a first nozzle structure terminates in a first plane orthogonal to the center axis of the nozzle structure, and further wherein the dispensing ends of one or more other nozzle structures terminate in one or more different planes than the first plane; providing a first flow of a first fluid composition at the first opening; providing a second flow of a second fluid composition at the second opening; dispensing the spray of particles from each nozzle structure using the first and second fluid compositions by creating a nonuniform electrical field between the dispensing ends from which the sprays are established and an electrode electrically isolated from the dispensing ends, wherein the particles have a nominal diameter of about 1 nanometer to about 2000 nanometers, and further wherein dispensing the spray of particles comprises dispensing a spray of microdroplets comprising an active ingredient, wherein the electrical charge is concentrated on the active ingredient as the microdroplet evaporates; providing a target structure comprising a surface upon which a coating is to be formed, wherein the target structure is positioned proximate the electrode electrically isolated from the dispensing ends, and further wherein the surface upon which the coating is to be formed lies between at least a portion of the electrode and the dispensing ends; and depositing the particles on the surface of the target structure to form a coating thereon. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. An electrospraying method, the method comprising:
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providing a plurality of nozzle structures, wherein each of the plurality of nozzle structures comprises at least two openings defined along a center axis of the nozzle structure and terminating at a dispensing end thereof from which a spray of particles having an electrical charge applied thereto is dispensed, wherein the at least two openings comprise at least a first and second opening terminating at the dispensing end of the at least one nozzle structure, wherein the dispensing end of a first nozzle structure terminates in a first plane orthogonal to the center axis of the nozzle structure, and further wherein dispensing ends of one or more other nozzle structures terminate in one or more different planes than the first plane; providing a first flow of a first fluid composition at the first opening; providing a second flow of a second fluid composition at the second opening; dispensing the spray of particles from the plurality of nozzle structures using the first and second fluid compositions by creating a nonuniform electrical field between the dispensing ends from which the spray is established and an electrode electrically isolated from the dispensing ends, wherein the particles have a nominal diameter of about 1 nanometer to about 2000 nanometers; providing a target structure comprising a surface upon which a coating is to be formed; and depositing the particles on the surface of the target structure to form a coating thereon. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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Specification