Cardiac signal template generation using waveform clustering

• US 7,499,751 B2
• Filed: 04/28/2005
• Issued: 03/03/2009
• Est. Priority Date: 04/28/2005
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Meyer, Scott A., Dong, Yanting
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): LEE, YUN H
• Application Number:
  US11/116,544
• Publication Number:
  US 20060247707A1
• Time in Patent Office: 1,405 Days
• Field of Search: 607/11, 607/27, 607/28, 600/510
• US Class Current: 607/28
• CPC Class Codes: A61B 5/35 by template matching
• CPC Class Codes: A61N 1/371 Capture, i.e. successful stimulation

Abstract

Cardiac devices and methods using cardiac waveform clustering for template generation are described. A method of characterizing a cardiac response involves delivering pacing pulses to heart, the pulses having an energy greater than a capture threshold. Cardiac signals are sensed following the pulses. Cardiac signal characteristics, waveforms, and/or features are clustered into a plurality of clusters. A cardiac response template is formed using one or more of the plurality of clusters.

Claims

1. A system for characterizing types of cardiac pacing responses, comprising:

a pulse generator configured to deliver pacing pulses to a heart;

a sensor system configured to sense cardiac signals following delivery of the pacing pulses;

a template processor configured to extract features of the cardiac signals and to cluster the features into a plurality of clusters, the processor further configured to select one or more predominant clusters from the plurality of clusters and to form a captured response template using the predominant clusters, and to select one or more less predominant clusters and to form an additional template characterizing a pacing response other than capture using the one or more less predominant clusters; and

a memory configured to store the captured response template and the additional template.

2. The system of claim 1, wherein the template processor is configured to cluster the features using one or both of K-means clustering and a self-organizing map algorithm.

3. The system of claim 1, wherein the template processor is configured to form an initial template using features of an initial cardiac signal and to modify the initial template using features of additional cardiac signals if the features of the additional cardiac signals are sufficiently similar to the initial template.

4. The system of claim 1, wherein the additional template formed using the less predominant clusters is associated with fusion.

5. The system of claim 1, wherein the additional template formed using the less predominant clusters is associated with intrinsic activation.

6. The system of claim 1, wherein the additional template formed using the less predominant clusters is associated with noise.

7. The system of claim 1, wherein the captured response template comprises a detection window associated with a cluster of negative peaks of the cardiac signals and a detection window associated with a cluster of positive peaks of the cardiac signals.

8. The system of claim 1, wherein the template processor is configured cluster each feature of a cardiac signal with similar features independently of other features of the cardiac signal.

9. The system of claim 1, wherein N cardiac signals are sensed following N pacing pulses and the processor is configured to form the captured response template using the predominant clusters if features of a predetermined number of the N cardiac signals are associated with the dominant clusters.

10. The system of claim 1, wherein the template processor is further configured to store information related to pacing energy with each of the templates.

11. The system of claim 10, wherein the information includes pacing voltage.

12. The system of claim 10, wherein the information includes pulse width.

13. The system of claim 1, wherein the template processor is further configured to store information related to pacing rate with each of the templates.

14. The system of claim 1, wherein the processor is further configured to store information related to a pacing interval with each of the templates.

15. The system of claim 14, wherein the pacing interval comprises an atrioventricular delay.

16. The system of claim 14, wherein the pacing interval comprises a ventricular pacing interval.

17. The system of claim 1, wherein:

the captured response template comprises a first capture detection window and a second capture detection window;

the first capture detection window is associated with a first predominant cluster of first peaks of the cardiac signals;

the second capture detection window is associated with a second predominant cluster of second peaks having opposite polarity from the first peaks;

the additional template comprises an intrinsic template comprising an intrinsic detection window; and

the intrinsic detection window is associated with a less predominant cluster of peaks of the cardiac signals, wherein each of the detection windows has positive and negative amplitude boundaries and positive and negative time boundaries.

18. The system of claim 17, further comprising a classification processor configured to classify a subsequent cardiac signal as a captured response if peaks of the subsequent cardiac signal fall within both of the captured response detection windows and to classify the subsequent cardiac signal as an intrinsic activation if a peak of the subsequent cardiac signal falls within the intrinsic detection window, and to classify the subsequent cardiac signal as fusion if peaks of the subsequent cardiac signal do not fall within both of the capture detection windows and do not fall within the intrinsic detection window.

19. The system of claim 18, wherein the subsequent cardiac signal is sensed in a first time interval and a second time interval following the pacing pulse and one of the captured response detection windows occurs within the first time interval and another of the captured response detection windows occurs within the second time interval.

20. The system of claim 19, wherein the second time interval is triggerable based on an event occurring in the first time interval.

21. The system of claim 1, wherein:

the pulse generator is configured to deliver the pacing pulses using a first electrode configuration; and

the sensing system is configured to sense the cardiac signals using a second electrode configuration that is different from the first electrode configuration.