Block copolymer particles

• US 7,501,179 B2
• Filed: 12/21/2005
• Issued: 03/10/2009
• Est. Priority Date: 12/21/2005
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Welch, Eric D., Bluni, Scott T., Song, Young-Ho
• Primary Examiner(s): KILIMAN, LESZEK B
• Application Number:
  US11/314,557
• Publication Number:
  US 20070141339A1
• Time in Patent Office: 1,175 Days
• Field of Search: 428/402, 428/403, 428/404, 428/405, 428/406, 428/407, 428/522
• US Class Current: 428/402
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 9/1635 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/1682 Processes
• CPC Class Codes: Y10T 428/2982 Particulate matter [e.g., sphere, flake, etc.]
• CPC Class Codes: Y10T 428/2991 Coated
• CPC Class Codes: Y10T 428/2993 Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
• CPC Class Codes: Y10T 428/2995 Silane, siloxane or silicone coating
• CPC Class Codes: Y10T 428/2996 Glass particles or spheres
• CPC Class Codes: Y10T 428/2998 including synthetic resin or polymer
• CPC Class Codes: Y10T 428/31935 Ester, halide or nitrile of addition polymer

Abstract

Block copolymer particles, and related compositions and methods, are disclosed.

Claims

1. A particle, comprising:

a biocompatible block copolymer including at least one first block having a glass transition temperature of at most 37°

C. and at least one second block having a glass transition temperature of greater than 37°

C.,

wherein the at least one first block comprises at least one isobutylene monomer and the particle has a diameter that is selected from the group consisting of less than about 100 microns, from about 300 microns to about 500 microns, from about 700 microns to about 900 microns, and from about 1,000 microns to about 1,200 microns.

2. The particle of claim 1, wherein the particle has a diameter of less than about 100 microns.

3. The particle of claim 1, wherein the particle has a diameter of from about 300 microns to about 500 microns.

4. The particle of claim 1, wherein the particle has a diameter of from about 700 microns to about 900 microns.

5. The particle of claim 1, wherein the particle has a diameter of from about 1,000 microns to about 1,200 microns.

6. The particle of claim 1, wherein the at least one second block comprises at least one block selected from the group consisting of vinyl aromatic blocks, methacrylate blocks, and combinations thereof.

7. The particle of claim 1, wherein the at least one second block comprises at least one monomer selected from the group consisting of styrene, α

-methylstyrene, and combinations thereof.

8. The particle of claim 1, wherein the block copolymer has the formula X-(AB)_n, A comprises the at least one first block, A is a isobutylene block, B comprises the at least one second block, B is a vinyl aromatic block or a methacrylate block, n is a positive whole number, and X is an initiator.

9. The particle of claim 8, wherein B is a methacrylate block.

10. The particle of claim 9, wherein B comprises at least one monomer selected from the group consisting of methylmethacrylate, ethylmethacrylate, hydroxyethyl methacrylate, and combinations thereof.

11. The particle of claim 8, wherein B is a vinyl aromatic block.

12. The particle of claim 11, wherein the at least one vinyl aromatic block comprises at least one monomer selected from the group consisting of styrene, α

-methylstyrene, and combinations thereof.

13. The particle of claim 1, further comprising a therapeutic agent.

14. The particle of claim 1, wherein the block copolymer forms a coating on the particle.

15. The particle of claim 1, further comprising a bioabsorbable material.

16. The particle of claim 1, further comprising a hydrogel.

17. The particle of claim 1, wherein the block copolymer has the formula BAB or ABA, in which A is the at least one first block and B is the at least one second block.

18. The particle of claim 1, wherein the block copolymer has the formula has the formula B(AB)n or A(BA)n, in which A is the at least one first block, B is the at least one second block, and n is a positive whole number.

19. The particle of claim 1, further comprising a second polymer.

20. The particle of claim 19, wherein the second polymer is blended with the block copolymer.

21. The particle of claim 19, wherein the second polymer comprises a second block copolymer.

32. The particle of claim 1, wherein the block copolymer comprises styrene-isobutylene-styrene.

22. A particle, comprising:

a biocompatible block copolymer including at least one first block having a glass transition temperature of at most 37°

C. and at least one second block having a glass transition temperature of greater than 37°

C.,

wherein the at least one first block comprises at least one isobutylene monomer and the particle has a diameter of about 1,050 microns or more.

23. The particle of claim 22, wherein the particle has a diameter of about 1,070 microns or more.

24. The particle of claim 22, wherein the particle has a diameter of about 1,090 microns or more.

25. The particle of claim 22, wherein the particle has a diameter of about 1,100 microns or more.

26. The particle of claim 22, wherein the particle has a diameter of about 1,150 microns or more.

33. The particle of claim 22, wherein the block copolymer comprises styrene-isobutylene-styrene.

27. A particle, comprising:

a matrix comprising a biocompatible block copolymer including at least one first block having a glass transition temperature of at most 37°

C. and at least one second block having a glass transition temperature of greater than 37°

C.; and

at least one sub-particle that is at least partially disposed within the matrix,

wherein the at least one first block comprises at least one isobutylene monomer and the particle has a diameter that is selected from the group consisting of less than about 100 microns, from about 300 microns to about 500 microns, from about 700 microns to about 900 microns, and from about 1,000 microns to about 1,200 microns.

28. The particle of claim 27, wherein the at least one sub-particle comprises a plurality of sub-particles.

29. The particle of claim 27, further comprising a first therapeutic agent.

30. The particle of claim 29, further comprising a second therapeutic agent that is different from the first therapeutic agent.

34. The particle of claim 27, wherein the block copolymer comprises styrene-isobutylene-styrene.

31. A particle, comprising:

a matrix comprising a biocompatible block copolymer including at least one first block having a glass transition temperature of at most 37°

C. and at least one second block having a glass transition temperature of greater than 37°

C.; and

at least one sub-particle that is at least partially disposed within the matrix,

wherein the at least one first block comprises at least one isobutylene monomer and the particle has a diameter of about 1,050 microns or more.

35. The particle of claim 31, wherein the block copolymer comprises styrene-isobutylene-styrene.