Method of treating skin inflammation
First Claim
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1. A method of treating skin inflammation in a subject comprising:
- a) measuring IL-17A, IL-17F, or both, in a non-lesional psoriatic skin sample from said subject using real-time PCR,b) determining that said subject exhibits at least 5-fold higher expression of IL-17A, IL-17F, or both compared to a normal skin sample, andc) administering an antagonist of IL-23 to effectively treat skin inflammation in said subject wherein said antagonist is an antibody or binding fragment thereof.
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Abstract
Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17 and/or IL-23.
32 Citations
7 Claims
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1. A method of treating skin inflammation in a subject comprising:
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a) measuring IL-17A, IL-17F, or both, in a non-lesional psoriatic skin sample from said subject using real-time PCR, b) determining that said subject exhibits at least 5-fold higher expression of IL-17A, IL-17F, or both compared to a normal skin sample, and c) administering an antagonist of IL-23 to effectively treat skin inflammation in said subject wherein said antagonist is an antibody or binding fragment thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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Specification