Water soluble tetrapyrollic photosensitizers for photodynamic therapy
First Claim
1. A tetrapyrollic photosensitizer compound having at least one pendant —
- CH2CH2CON(CH2CON(CH2COOH)2)2 or —
N(CH2COOH)2 group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide.
2 Assignments
0 Petitions
Accused Products
Abstract
A tetrapyrollic photosensitizer compound having at least one pendant —CH2CH2CON(CH2CON(CH2COOH)2)2 or —N(CH2COOH)2 group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide. Desirably the compound has the formula:
or a phamaceutically acceptable derivative thereof, wherein R1-R8 and R10 are various substituents and R9 is substituted or unsubstituted —CH2CH2CON(CH2CON(CH2COOH)2)2; or —N(CH2COOH)2. The invention also includes a method of treatment by photodynamic therapy by treatment with light after injecting the compound and a method of imaging by fluorescence after injection of the compound.
-
Citations
12 Claims
-
1. A tetrapyrollic photosensitizer compound having at least one pendant —
- CH2CH2CON(CH2CON(CH2COOH)2)2 or —
N(CH2COOH)2 group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide. - View Dependent Claims (11)
- CH2CH2CON(CH2CON(CH2COOH)2)2 or —
- 2. A compound of the formula:
Specification