Obtaining information from optical cavity output light

• US 7,502,123 B2
• Filed: 02/05/2007
• Issued: 03/10/2009
• Est. Priority Date: 02/05/2007
• Status: Active Grant

• Current Assignee: Xerox Corporation (Xerox Holdings Corp.)
• Original Assignee: Palo Alto Research Center, Inc. (Xerox Holdings Corp.)
• Inventors: Kiesel, Peter, Bassler, Michael, Schmidt, Oliver
• Primary Examiner(s): Lyons; Michael A
• Application Number:
  US11/702,249
• Publication Number:
  US 20080186500A1
• Time in Patent Office: 764 Days
• Field of Search: 356/454, 356/480, 356/519
• US Class Current: 356/519
• CPC Class Codes: G01N 21/0303 Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment G01N21/031 - G01N21/15 take precedence
• CPC Class Codes: G01N 21/253 for batch operation, i.e. multisample apparatus analytical automats G01N35/00
• CPC Class Codes: G01N 21/39 using tunable lasers

Abstract

Output light from an optical cavity includes, for each of a set of modes, an intensity function, and a mode'"'"'s intensity function includes information, such as about an optical characteristic of an analyte or of a region. For example, the intensity function can include a peak, and its central energy, maximum intensity, contrast, or intermediate intensity width (e.g. FWHM) can indicate the optical characteristic. The output light can be photosensed, providing electrical signals that depend on the optical characteristic. Information about the analyte or region can then be obtained using the electrical signals. For example, the information can be about both refractive index and absorption of an analyte. Cavity-only absorption values, independent, for example, of absorption outside the cavity and of inhomogeneous illumination, can be obtained based on contrast or intermediate intensity width. For detection of glucose in bodily fluid, derivatives of absorption can be obtained.

Claims

1. A device comprising:

a photosensing component that, in use, photosenses output light from an optical cavity that provides light in a set of one or more modes;

for one or more of the modes in the set, the output light including a respective intensity function;

the intensity function of at least one of the modes including information about an optical absorption characteristic of an analyte present in the optical cavity or of a region of the optical cavity;

in response to the output light, the photosensing component providing electrical signals that depend on the optical absorption characteristic; and

an information obtaining component that uses the electrical signals to obtain information about the analyte or the region.

2. The device of claim 1, further comprising an optical cavity structure that includes the optical cavity;

the optical cavity being one of a laser and a transmissive cavity.

3. The device of claim 2 in which the optical cavity is a Fabry-Perot cavity.

4. The device of claim 2 in which the optical cavity provides each of the intensity functions with a respective intensity peak.

5. The device of claim 2 in which the optical cavity is a transmissive cavity;

the modes being transmission modes or reflection modes.

6. The device of claim 1 in which the intensity function of each of the at least one of the modes includes information about an optical characteristic of an analyte present in the optical cavity, the information obtaining component obtaining information about the optical characteristic of the analyte.

7. The device of claim 1 in which the photosensing component includes at least one of a position-sensitive detector and a photosensing array.

8. A system that includes the device of claim 1;

the information obtaining component comprising;

processing circuitry that receives the electrical signals from the photosensing component;

the processing circuitry using the electrical signals to obtain information about the analyte or the region.

9. The system of claim 8 in which the processing circuitry includes a central processing unit.

10. The system of claim 8, further comprising:

an optical cavity component that includes the optical cavity;

the processing circuitry further controlling the optical cavity component.

11. A method of using optical cavities;

the method comprising;

photosensing output light from an optical cavity that provides light in a set of one or more modes;

for one or more of the modes in the set, the output light including a respective intensity function;

the intensity function of at least one of the modes including information about an optical characteristic of an analyte carried by fluid through a succession of positions in the optical cavity or about a changeable optical characteristic of a region of the optical cavity;

the act of photosensing output light comprising;

providing electrical signals that depend on the optical characteristic of the analyte or on the changeable optical characteristic of the region and

using the electrical signals to obtain information about the analyte or the region.

12. The method of claim 11 in which the act of photosensing further comprises:

photosensing intensity of the output light from the optical cavity in each of a set of two or more photon energy subranges;

the act of providing electrical signals comprising;

for each of the photon energy subranges, providing an electrical signal indicating photosensed intensity.

13. The method of claim 11 in which the act of using the electrical signals to obtain information comprises:

obtaining information about the optical characteristic of the analyte.

14. The method of claim 13 in which the act of obtaining information comprises:

obtaining information about at least one of a refraction characteristic and an absorption characteristic of the analyte.

15. The method of claim 14 in which the act of obtaining information further comprises:

obtaining information about both refractive index and optical absorption of the analyte.

16. The method of claim 11 in which the act of using the electrical signals to obtain information comprises:

obtaining information about one or more of refractive index, dispersion, and absorption spectrum.

17. The method of claim 16 in which the act of obtaining information comprises:

obtaining two or more refractive index values and using the refractive index values to obtain a dispersion value.

18. The method of claim 11 in which the act of using the electrical signals comprises:

obtaining cavity-only absorption data.

19. A method of using optical cavities;

the method comprising;

photosensing output light from an optical cavity that provides light in a set of one or more modes;

for one or more of the modes in the set, the output light including a respective intensity function;

the intensity function of at least one of the modes including information about an optical characteristic of an analyte present in the optical cavity or of a region of the optical cavity;

the act of photosensing output light comprising;

providing electrical signals that depend on the optical characteristic; and

using the electrical signals to obtain information about the analyte or the region;

the intensity function of a first one of the modes including a respective intensity peak;

the act of using the electrical signals comprising obtaining information about at least one of;

a central energy of the first mode'"'"'s intensity peak;

contrast of the first mode'"'"'s intensity peak;

an intermediate intensity width of the first mode'"'"'s intensity peak; and

a maximum intensity of the first mode'"'"'s intensity peak.

20. The method of claim 19 in which the intensity function of a second one of the modes also includes a respective intensity peak;

the respective intensity peaks of the first and second modes being different in at least one of central energy, contrast, maximum intensity, and intermediate intensity width.

21. A system comprising:

a photosensing component that, in use, photosenses output light from a sample optical cavity that provides output light in a set of one or more modes, each having a respective intensity function;

a fluid sample being present in the optical cavity;

in response to the output light, the photosensing component providing electrical signals that depend on whether an analyte is present in the fluid sample;

if the analyte is present, an optical characteristic of the analyte affecting the respective intensity function of at least one of the modes in the set, the electrical signals indicating a feature of the intensity function; and

an information obtaining component that uses the electrical signals to obtain information about presence of the analyte in the fluid sample.

22. The system of claim 21, further comprising:

an optical cavity component that includes the sample optical cavity;

the optical cavity component further including a reference optical cavity that contains a reference medium;

the photosensing component further photosensing output light from the reference optical cavity;

the electrical signals indicating an optical characteristic of the reference medium;

the information obtaining component obtaining an adjusted value for the analyte'"'"'s presence in the fluid sample, the adjusted value depending on the optical characteristic of the reference medium.

23. The system of claim 22 in which the fluid sample includes bodily fluid and the reference medium includes fluid with a known concentration of the analyte.

24. A method of using optical cavities;

the method comprising;

photosensing output light from an optical cavity that provides output light in a set of one or more modes, each having a respective intensity function;

a sample being present in the optical cavity;

the act of photosensing output light comprising;

providing electrical signals that depend on whether an analyte is present in the sample;

if the analyte is present, an optical absorption characteristic of the analyte affecting the respective intensity function of at least one of the modes in the set, the electrical signals indicating a feature of the intensity function; and

using the electrical signals to obtain information about presence of the analyte in the sample.

25. The method of claim 24 in which the sample is bodily fluid and the analyte is glucose.

26. The method of claim 24 in which the act of using the electrical signals comprises:

obtaining a set of one or more derivatives of the absorption characteristic as a function of photon energy;

each derivative being obtained for a respective subrange of photon energies and the subranges being different.

27. A method of using optical cavities;

the method comprising;

photosensing output light from an optical cavity that provides light in a set of one or more modes;

for one or more of the modes in the set, the output light including a respective intensity function;

the intensity function of at least one of the modes including information about an optical characteristic of an analyte present in the optical cavity or of a region of the optical cavity;

the act of photosensing output light comprising;

providing electrical signals that depend on the optical characteristic; and

using the electrical signals to obtain information about the analyte or the region;

the act of using the electrical signals comprising at least one of;

obtaining information about both refractive index and optical absorption;

obtaining two or more refractive index values and using the refractive index values to obtain a dispersion value; and

obtaining cavity-only absorption data.

28. The method of claim 27 in which the act of obtaining information about both refractive index and optical absorption comprises:

obtaining information about refractive index at a first set of one or more photon energies; and

obtaining information about optical absorption at a second set of one or more photon energies;

the first and second sets of photon energies being different.

29. The method of claim 27 in which the cavity-only absorption data include at least one of a contrast value and an intermediate intensity width value.