Gastrointestinal methods and apparatus for use in treating disorders
First Claim
1. A method for treating a subject, comprising:
- applying an electrical signal to a site of the subject selected from the group consisting of;
a colon of the subject, and a distal small intestine of the subject; and
configuring the signal to stimulate cells of the subject to increase secretion of glucagon-like-peptide-1 (GLP-1), in order to treat the subject,wherein configuring the signal comprises;
detecting an occurrence selected from the group consisting of an occurrence of eating, an occurrence of excessive eating, and an occurrence of an elevated blood glucose level; and
responsive to detecting the occurrence, increasing a strength of the signal.
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Accused Products
Abstract
A method is provided for detecting a change in posture of a subject. An electrical impedance is measured between two or more sites on a stomach (20) of the subject, and an impedance signal is generated responsive thereto. The change in posture is detected by performing a posture analysis of the impedance signal. A method is also provided for treating a subject. The method includes applying an electrical signal to a site of the subject selected from the list consisting of: a colon (402) of the subject, and a distal small intestine (408) of the subject. The signal is configured to stimulate cells of the subject to increase secretion of glucagon-like-peptide-1 (GLP-1) or PYY, or to decrease secretion of ghrelin, in order to treat the subject.
356 Citations
41 Claims
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1. A method for treating a subject, comprising:
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applying an electrical signal to a site of the subject selected from the group consisting of;
a colon of the subject, and a distal small intestine of the subject; andconfiguring the signal to stimulate cells of the subject to increase secretion of glucagon-like-peptide-1 (GLP-1), in order to treat the subject, wherein configuring the signal comprises; detecting an occurrence selected from the group consisting of an occurrence of eating, an occurrence of excessive eating, and an occurrence of an elevated blood glucose level; and responsive to detecting the occurrence, increasing a strength of the signal. - View Dependent Claims (2, 3)
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4. A method for treating a subject, comprising:
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applying an electrical signal to a site of the subject selected from the group consisting of;
a colon of the subject, and a distal small intestine of the subject;configuring the signal to stimulate cells of the subject to increase secretion of glucagon-like-peptide-1 (GLP-1), in order to treat the subject; and detecting eating by the subject, wherein applying the electrical signal comprises applying the signal responsive to detecting the eating. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. Apparatus for treating a subject, comprising:
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at least one electrode, adapted to be coupled to a site of the subject selected from the group consisting of;
a colon of the subject, and a distal small intestine of the subject;a detection unit configured to detect an occurrence selected from the group consisting of;
an occurrence of eating, an occurrence of excessive eating, and an occurrence of an elevated blood glucose level, and generate a detection unit signal in response thereto; anda control unit, adapted to drive the at least one electrode to apply an electrical treatment signal to the site, and to configure the treatment signal to stimulate cells of the subject to increase secretion of glucagon-like-peptide-1 (GLP-1), in order to treat the subject, and responsive to receiving the detection unit signal indicative of the detected occurrence, increase a strength of the treatment signal. - View Dependent Claims (23, 24)
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25. Apparatus for treating a subject, comprising:
- p1 at least one electrode, adapted to be coupled to a site of the subject selected from the group consisting of;
a colon of the subject, and a distal small intestine of the subject;a detection unit adapted to detect eating by the subject, and generate a detection unit signal in response thereto; and a control unit, adapted to drive the at least one electrode to apply an electrical treatment signal to the site responsive to receiving the detection unit signal indicative of the detected eating, and to configure the treatment signal to stimulate cells of the subject to increase secretion of glucagon-like-peptide-1 (GLP-1), in order to treat the subject. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
- p1 at least one electrode, adapted to be coupled to a site of the subject selected from the group consisting of;
Specification