Apparatus for the continuous separation of biological fluids into components and method of using same

• US 7,503,889 B2
• Filed: 04/19/2006
• Issued: 03/17/2009
• Est. Priority Date: 03/04/2002
• Status: Expired due to Term

• Current Assignee: Mallinckrodt Critical Care Finance Inc (Mallinckrodt plc), Mallinckrodt Pharma Ip Trading DAC (Mallinckrodt plc)
• Original Assignee: Therakos, Inc (Mallinckrodt plc)
• Inventors: Hutchinson, Mike, Gara, Steve, Briggs, Dennis, Watters, Tom
• Primary Examiner(s): Reifsnyder; David A
• Application Number:
  US11/407,271
• Publication Number:
  US 20060189469A1
• Time in Patent Office: 1,063 Days
• Field of Search: 210/360.1, 210/360.2, 210/363, 210/380.1, 494/41, 494/43, 494/44, 494/67, 494/76, 494/77
• US Class Current: 494/44
• CPC Class Codes: A61K 41/0066 Psoralene-activated UV-A photochemotherapy (PUVA-therapy), e.g. for treatment of psoriasis or eczema, extracorporeal photopheresis with psoralens or fucocoumarins
• CPC Class Codes: A61M 1/0227 and means for securing the filter against damage, e.g. during centrifugation
• CPC Class Codes: A61M 1/361 before treatment
• CPC Class Codes: A61M 1/362227 the interface providing means for actuating on functional elements of the cassette, e.g. plungers
• CPC Class Codes: A61M 1/36224 with sensing means or components thereof
• CPC Class Codes: A61M 1/36225 with blood pumping means or components thereof
• CPC Class Codes: A61M 1/36226 Constructional details of cassettes, e.g. specific details on material or shape
• CPC Class Codes: A61M 1/362263 Details of incorporated filters
• CPC Class Codes: A61M 1/362265 Details of valves
• CPC Class Codes: A61M 1/362266 Means for adding solutions or substances to the blood
• CPC Class Codes: A61M 1/3681 by irradiation
• CPC Class Codes: A61M 1/3683 using photoactive agents
• CPC Class Codes: A61M 1/3686 by removing photoactive agents after irradiation
• CPC Class Codes: A61M 1/3693 using separation based on different densities of components, e.g. centrifuging
• CPC Class Codes: A61M 1/3696 with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
• CPC Class Codes: A61M 1/72 Cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 1/77 Suction-irrigation systems aspiration tips supplying fluids A61M1/85; specific for negative pressure wound therapy A61M1/92; combined with tracheal tubes A61M16/0463
• CPC Class Codes: A61M 2202/0092 starting product created by centrifuging
• CPC Class Codes: A61M 2202/0427 Platelets; Thrombocytes
• CPC Class Codes: A61M 2205/051 with radiation therapy
• CPC Class Codes: A61M 2205/053 : ultraviolet
• CPC Class Codes: A61M 2205/12 : with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/125 : with incorporated filters
• CPC Class Codes: A61M 2205/35 : Communication
• CPC Class Codes: A61M 2205/50 : with microprocessors or computers
• CPC Class Codes: A61M 2205/52 : with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/60 : with identification means
• CPC Class Codes: A61M 2205/75 : with filters
• CPC Class Codes: A61M 3/0201 : Cassettes therefor
• CPC Class Codes: B04B 2005/0464 : with hollow or massive core in centrifuge bowl
• CPC Class Codes: B04B 2005/0492 : with fluid conveying umbilicus between stationary and rotary centrifuge parts
• CPC Class Codes: B04B 5/0442 : with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
• CPC Class Codes: F04B 43/1253 : by using two or more rollers as squeezing elements, the rollers moving on an arc of a circle during squeezing
• CPC Class Codes: F16L 33/00 : Arrangements for connecting hoses to rigid members; Rigid hose connectors, i.e. single members engaging both hoses
• CPC Class Codes: F16L 39/02 : for hoses

Abstract

The present invention provides an apparatus for separating components of a fluid having an outer housing containing a core wherein three separate fluid pathways are provided to allow continuous separation of biological fluids.

Claims

1. A connection sleeve (500A) for fluidly connecting an external conduit (20A) having a first conduit channel (780A) to a lumen (400A) of a centrifuge bowl (10A) having a first bowl channel (420A), said connection sleeve (500A) comprising;

a body (830A) having an upper sleeve end (831 A) and a lower sleeve end (832A), said lower sleeve end (832A) adapted to be secured to said centrifuge bowl (10A);

a sleeve wall (835A) adapted to receive and hold said external conduit (20A);

said sleeve wall (835A) reinforced by one to four sleeve rings (833A); and

a sleeve flange (790A) on said lower sleeve end (832A), said sleeve flange (790A) having a bottom surface (847A) and encircling a lumen mounting recess (851A) adapted to engage a lumen connector (481A) and outer housing outlet (700A) of said centrifuge bowl (10A).

2. The connection sleeve (500A) of claim 1 wherein said bottom surface (847A) further comprises protrusions (843A) for engaging lumen connector (481A).

3. The connection sleeve (500A) of claim 1 wherein said connection sleeve (500A) is adapted to be overmolded to said external conduit (20A).

4. The connection sleeve (500A) of claim 1 wherein said connection sleeve (500A) is made of a same material as external conduit (20A).

5. The connection sleeve (500A) of claim 1 wherein said lumen mounting recess (851A) and the top surface (482A) of lumen connector (481A).

6. An anchor sleeve (870A) for securing an external conduit (20A) having conduit channels (760A, 770A, 780A) to a restraint (918A), said anchor sleeve (870A) comprising:

a body (870A) having a first anchor end (873A) and a second anchor end (874A);

a plurality of longitudinal ribs (877A) in parallel with said conduit channels, said longitudinal ribs having first rib ends (877B) and second rib ends (877C) said second rib ends (877C) extending beyond the first anchor end (873A).

7. An anchor sleeve of claim 6 wherein the number of longitudinal ribs is three.

8. A conduit assembly (860A) for fluidly connecting a source (600) of fluid (800) to a centrifuge bowl (10A) comprising:

an external conduit (20A) of approximately constant diameter having a first conduit end (861A) and a second conduit end (862A);

a connection sleeve (500A) secured to said first conduit end (861A), said connection sleeve (500A) adapted to fluidly connect to said centrifuge bowl (10A);

an anchor sleeve (870A) secured to said second conduit end (862A);

a first bearing ring (871A) surrounding said external conduit (20A) and positioned between said connection sleeve (500A) and said anchor sleeve (870A), said first bearing ring (871A) adapted to engage a means (900) for rotating said centrifuge bowl (10A); and

a first assembly channel (990A), a second assembly channel (991A), and a third assembly channel (992A) extending through said conduit assembly (860A).

9. The conduit assembly (860A) of claim 8 wherein said connection sleeve (500A) and said anchor sleeve (870A) are overmolded to said external conduit (20A).

10. The conduit assembly (860A) of claim 8 wherein:

said anchor sleeve (870A) has a first anchor end (873A) and a second anchor end (874A), said first anchor end (873A) being secured to said external conduit (20A), said anchor sleeve (870A) increasing in diameter from said first anchor end (873A) to said second anchor end (874A);

said connection sleeve (500A) has an upper sleeve end (831A) and a lower sleeve end (832A), said upper sleeve end (831A) being secured to said external conduit (20A), said connection sleeve (500A) increasing in diameter from said upper sleeve end (831A) to said lower sleeve end (832A); and

said anchor sleeve (870A), connection sleeve (500A), and external conduit (20A) are made of the composition.

11. The conduit assembly (860A) of claim 8 wherein said connection sleeve (500A) comprises a sleeve flange (790A).

12. The conduit assembly (860A) of claim 8 further comprising a second bearing ring (872A) surrounding said conduit (20A) and positioned between said first bearing ring (871A) and said anchor sleeve (870A), said second bearing ring (872A) adapted to engage a means (900) for rotating said centrifuge bowl (10A).

13. The conduit assembly (860A) of claim 8 wherein said first and second bearing rings (871A, 872A) are 7.5 to 9.5 inches apart.

14. The conduit assembly (860A) of claim 13 wherein said first bearing ring (871A) is 5.0 to 5.5 inches from a lower end (832A) of said connection sleeve (500A).