Method and apparatus for continuous pulse contour cardiac output

• US 7,507,208 B2
• Filed: 05/21/2008
• Issued: 03/24/2009
• Est. Priority Date: 01/27/2005
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Bennett, Tommy D., Taepke, Robert T. II, Kjellstrom, Barbro M.
• Primary Examiner(s): Nasser; Robert L
• Application Number:
  US12/124,847
• Publication Number:
  US 20080243006A1
• Time in Patent Office: 307 Days
• Field of Search: None
• US Class Current: 600/485
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02108 from analysis of pulse wave characteristics
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval

Abstract

A system and method are provided for sensing cardiac electrogram (EGM) signals and ventricular pressure signals and for using the sensed EGM and sensed pressure signals for estimating stroke volume (SV). A measure of cardiac output can be computed from the estimated SV and a heart rate determined from the EGM signals. The sensed ventricular pressure signal and the sensed EGM signal are used to derive landmark points such as an estimated pulmonary diastolic pressure, a mean pulmonary artery pressure, a peak right ventricular pressure (RVP), and various time intervals used in computing an area or a pulse contour integral. The pulse contour integral is used to estimate SV. The estimated pulmonary diastolic pressure, mean pulmonary artery pressure and CO computed from the estimated SV can be used to compute a pulmonary vascular resistance.

Claims

1. A method, comprising:

sensing a cardiac electrogram (EGM) signal of the heart;

sensing a right ventricular pressure (RVP) signal;

computing an estimated stroke volume using the sensed EGM signal and the sensed RVP signal;

wherein computing an estimated stroke volume comprises computing a RVP pulse contour integral by;

identifying an integration start time corresponding to an estimated time of pulmonic valve opening;

identifying an integration end time corresponding to an estimated time of pulmonic valve closure;

computing the area under the right ventricular pressure signal between the integration start time and the integration end time; and

wherein computing the RVP pulse contour comprises computing a plurality of correction areas used to adjust the area under the right ventricular pressure signal between the integration start time and the integration end time; and

one of displaying and storing in a memory structure at least one of;

the RVP pulse contour, the estimated stroke volume, the right ventricular pressure signal, the area.

2. A method according to claim 1 wherein sensing the right ventricular pressure signal further comprises:

detecting an R-wave event from the sensed EGM signal;

setting an analysis window for a predetermined interval of time following the R-wave event detection; and

acquiring and storing the RVP signal during the analysis window.

3. A method according to claim 1 wherein computing an estimated stroke volume further comprises:

deriving an estimated pulmonary artery diastolic pressure from the RVP signal;

deriving a peak right ventricular pressure amplitude from the RVP signal; and

computing a difference between the estimated pulmonary artery diastolic pressure and the peak right ventricular pressure amplitude.

4. A method according to claim 1 wherein the estimated time of pulmonic valve opening is a time corresponding to a maximum rate of pressure rise in the right ventricular pressure signal.

5. A method according to claim 1 wherein the estimated time of pulmonic valve closure is a time corresponding to a right ventricular pressure amplitude occurring on a descending portion of the right ventricular pressure signal and equaling a right ventricular pressure amplitude at the integration start time.

6. A method according to claim 1 wherein computing a plurality of correction areas comprises:

deriving an estimated pulmonary artery diastolic pressure using the right ventricular pressure signal and the EGM signal, and

computing the area below the estimated pulmonary artery diastolic pressure and between the integration start time and the integration end time.

7. A method according to claim 1 wherein computing a plurality of correction areas comprises:

deriving a mean pulmonary artery pressure using the RVP signal and the EGM signal;

identifying a corrected integration end time corresponding to a time that a RVP signal amplitude occurring on a descending portion of the right ventricular pressure signal equals the estimated mean pulmonary artery pressure;

arid

computing an area under the right ventricular pressure signal between the corrected integration end time and the integration end time.

8. A method according to claim 1 wherein computing a plurality of correction areas comprises:

deriving a mean pulmonary artery pressure using the RVP signal and the EGM signal;

identifying a corrected integration end time corresponding to a time that a RVP signal amplitude occurring on a descending portion of the right ventricular pressure signal equals the estimated mean pulmonary artery pressure;

deriving an estimated pulmonary artery diastolic pressure using the right ventricular pressure signal and the EGM signal;

computing a triangular area having sides defined by a horizontal line corresponding to the estimated pulmonary artery diastolic pressure, a vertical line corresponding to the corrected integration end time, and a line segment intersecting the horizontal line at a point on a descending portion of the RVP signal equal in amplitude to the derived mean pulmonary artery pressure and intersecting the vertical line at a point on an ascending portion of the RVP signal equal to the estimated pulmonary artery diastolic pressure.

9. A method according to claim 1 wherein computing a plurality of correction areas comprises computing a correction area corresponding to changes in pulmonary vascular resistance.

10. A method according to claim 9 wherein computing a correction area corresponding to changes in pulmonary vascular resistance comprises:

deriving a mean pulmonary artery pressure using the RVP signal and the EGM signal;

identifying a corrected integration end time, corresponding to a time that a RVP signal amplitude occurring on a descending portion of the right ventricular pressure signal equals the estimated mean pulmonary artery pressure;

deriving an estimated pulmonary artery diastolic pressure using the right ventricular pressure signal and the EGM signal;

computing a slope between the mean pulmonary artery pressure and the estimated pulmonary artery diastolic pressure over a time interval derived from the EGM signal corresponding to a diastolic interval and pre-ejection interval;

computing the area of a triangle defined by the slope applied between the integration start time and the corrected integration end time.

11. A method according to claim 1 wherein computing the estimated stroke volume comprises computing the RVP pulse contour integral as a function of the area under the RVP curve between the integration start time and the integration end time and the plurality of correction areas.

12. A method according to claim 1 further comprising computing a cardiac output from the estimated stroke volume and a heart rate derived from the EGM signal.

13. A method according to claim 1 further comprising computing a cardiac output using the estimated stroke volume and a heart rate derived from the EGM signal.

14. A method for monitoring the hemodynamic status of a patient, comprising:

sensing a cardiac electrogram (EGM) signal of the heart;

sensing a right ventricular pressure (RVP) signal;

computing an estimated stroke volume using the sensed EGM signal and the sensed RVP signal;

deriving a mean pulmonary artery pressure using the RVP signal and the EGM signal; and

deriving an estimated pulmonary artery diastolic pressure using the right ventricular pressure signal and the EGM signal; and

computing a pulmonary vascular resistance using the sensed EGM signal and the sensed RVP signal;

wherein computing a pulmonary vascular resistance comprises;

computing a pressure difference between the mean pulmonary artery pressure and the estimated pulmonary artery diastolic pressure;

computing a cardiac output metric using the estimated stroke volume and a heart rate derived from the EGM signal;

dividing the pressure difference by the cardiac output; and

one of displaying and storing in a memory structure at least one of;

the cardiac output metric, the estimated stroke volume, the heart rate, the pressure difference, the pulmonary vascular resistance, the right ventricular pressure, the mean pulmonary, artery pressure, the estimated pulmonary artery diastolic pressure.