High viscosity embolizing compositions
First Claim
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1. A composition capable of embolizing an aneurysm at a vascular site comprising:
- (a) a biocompatible polymer;
(b) a biocompatible contrast agent wherein a sufficient amount of said contrast agent is employed in said composition to effect visualization in vivo; and
(c) a biocompatible solvent which solubilizes said biocompatible polymerwherein a sufficient amount of said polymer are employed in said composition such that, upon delivery to a vascular site, a polymer precipitate forms which embolizes said vascular site; and
further wherein the biocompatible polymer has a molecular weight sufficient to impart to the composition a viscosity of at least about 150 cSt at 40°
C.
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Abstract
Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery.
48 Citations
17 Claims
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1. A composition capable of embolizing an aneurysm at a vascular site comprising:
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(a) a biocompatible polymer; (b) a biocompatible contrast agent wherein a sufficient amount of said contrast agent is employed in said composition to effect visualization in vivo; and (c) a biocompatible solvent which solubilizes said biocompatible polymer wherein a sufficient amount of said polymer are employed in said composition such that, upon delivery to a vascular site, a polymer precipitate forms which embolizes said vascular site; and further wherein the biocompatible polymer has a molecular weight sufficient to impart to the composition a viscosity of at least about 150 cSt at 40°
C. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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2. A composition capable of embolizing an aneurysm at a vascular site comprising:
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(a) a biocompatible polymer at a concentration of from about 2 to 50 weight percent; (b) a biocompatible contrast agent at a concentration of from about 10 to about 40 weight percent; and (c) a biocompatible solvent from about 10 to 88 weight percent wherein the weight percents of the biocompatible polymer, contrast agent and biocompatible solvent are based on the total weight of the composition; and further wherein the biocompatible polymer has a molecular weight sufficient to impart to the composition a viscosity of at least about 150 cSt at 40°
C.
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Specification