Delivery of muscle relaxants through an inhalation route
First Claim
1. A condensation aerosol for delivery of quinine formed by heating a composition containing quinine coated on a solid support to form a vapor and condensing the vapor to form a condensation aerosol comprising particles, wherein the particles comprise at least 10 percent by weight of quinine and less than 5 percent by weight of quinine degradation products, and the condensation aerosol has an MMAD of less than 5 microns.
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Abstract
The present invention relates to the delivery of muscle relaxants through an inhalation route. Specifically, it relates to aerosols containing muscle relaxants that are used in inhalation therapy. In a method aspect of the present invention, a muscle relaxant is delivered to a patient through an inhalation route. The method comprises: a) heating a coating of a muscle relaxant, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% muscle relaxant degradation products. In a kit aspect of the present invention, a kit for delivering a muscle relaxant through an inhalation route is provided which comprises: a) a coating of a muscle relaxant and b) a device for dispensing said coating a muscle relaxant as a condensation aerosol.
243 Citations
46 Claims
- 1. A condensation aerosol for delivery of quinine formed by heating a composition containing quinine coated on a solid support to form a vapor and condensing the vapor to form a condensation aerosol comprising particles, wherein the particles comprise at least 10 percent by weight of quinine and less than 5 percent by weight of quinine degradation products, and the condensation aerosol has an MMAD of less than 5 microns.
- 4. A condensation aerosol for delivery of chlorzoxazone formed by heating a composition containing chlorzoxazone coated on a solid support to form a vapor and condensing the vapor to form a condensation aerosol comprising particles, wherein the particles comprise at least 10 percent by weight of chlorzoxazone and less than 5 percent by weight of chlorzoxazone degradation products, and the condensation aerosol has an MMAD of less than 5 microns.
- 7. A condensation aerosol for delivery of carisoprodol formed by heating a composition containing carisoprodol coated on a solid support to form a vapor and condensing the vapor to form a condensation aerosol comprising particles, wherein the particles comprise at least 10 percent by weight of carisoprodol and less than 5 percent by weight of carisoprodol degradation products, and the condensation aerosol has an MMAD of less than 5 microns.
- 10. A condensation aerosol for delivery of cyclobenzaprine formed by heating a composition containing cyclobenzaprine coated on a solid support to form a vapor and condensing the vapor to form a condensation aerosol comprising particles, wherein the particles comprise at least 10 percent by weight of cyclobenzaprine and less than 5 percent by weight of cyclobenzaprine degradation products, and the condensation aerosol has an MMAD of less than 5 microns.
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13. A method of forming a quinine containing aerosol comprising:
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(a) heating a composition containing quinine coated on a solid support to form a vapor, and (b) condensing the vapor to form a condensation aerosol comprising particles, wherein the particles comprise less than 5 percent by weight of quinine degradation products, and the condensation aerosol has an MMAD of less than 5 microns. - View Dependent Claims (14, 15, 31)
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16. A method of forming a chlorzoxazone containing aerosol comprising:
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(a) heating a composition containing chlorzoxazone coated on a solid support to form a vapor, and (b) condensing the vapor to form a condensation aerosol comprising particles, wherein the particles comprise less than 5 percent by weight of chlorzoxazone degradation products, and the condensation aerosol has an MMAD of less than 5 microns. - View Dependent Claims (17, 18, 32)
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19. A method of forming a carisoprodol containing aerosol comprising:
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(a) heating a composition containing carisoprodol coated on a solid support to form a vapor, and (b) condensing the vapor to form a condensation aerosol comprising particles, wherein the particles comprise less than 5 percent by weight of carisoprodol degradation products, and the condensation aerosol has an MMAD of less than 5 microns. - View Dependent Claims (20, 21, 33)
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22. A method of forming a cyclobenzaprine containing aerosol comprising:
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(a) heating a composition containing cyclobenzaprine coated on a solid support to form a vapor, and (b) condensing the vapor to form a condensation aerosol comprising particles, wherein the particles comprise less than 5 percent by weight of cyclobenzaprine degradation products, and the condensation aerosol has an MMAD of less than 5 microns. - View Dependent Claims (23, 24, 34)
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25. A method of forming a drug containing aerosol comprising:
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(a) heating a composition containing the drug and a pharmaceutically acceptable excipient coated on a solid support to form a vapor, and (b) condensing the vapor to form a condensation aerosol comprising particles, wherein the drug is selected from the group consisting of quinine, chlorzoxazone, carisoprodol and cyclobenzaprine, and wherein the particles comprise at least 10 percent by weight of the drug and less than 5 percent by weight of the drug quinine degradation products, and the condensation aerosol has an MMAD of less than 5 microns. - View Dependent Claims (35, 36, 37)
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26. A method of forming a drug containing aerosol comprising:
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(a) heating a composition containing a salt form of the drug coated on a solid support to form a vapor, and (b) condensing the vapor to form a condensation aerosol comprising particles, wherein the drug is selected from the group consisting of quinine, chlorzoxazone, carisoprodol, and cyclobenzaprine, and wherein the particles comprise at least 10 percent by weight of the drug and less than 5 percent by weight of the drug degradation products, and the condensation aerosol has an MMAD of less than 5 microns. - View Dependent Claims (38, 39, 40)
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41. A method of forming a drug containing aerosol comprising:
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(a) heating a composition containing the drug coated on a solid support to form a vapor, and (b) condensing the vapor to form a condensation aerosol comprising particles, wherein the drug is selected from the group consisting of quinine, chlorzoxazone, carisoprodol, and cyclobenzaprine, wherein the condensation aerosol is formed at a rate greater than 0.5 mg/second, and wherein the particles comprise at least 10 percent by weight of the drug and less than 5 percent by weight of the drug degradation products, and the condensation aerosol has an MMAD of less than 5 microns. - View Dependent Claims (42, 43, 44, 45, 46)
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Specification