Magnetic resonance imaging system, a method of magnetic resonance imaging and a computer program

• US 7,508,205 B2
• Filed: 04/27/2005
• Issued: 03/24/2009
• Est. Priority Date: 04/29/2004
• Status: Expired due to Fees

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Bos, Clemens, Thelissen, Guillaume Rudolf Petrus
• Primary Examiner(s): Shrivastav; Brij B
• Application Number:
  US11/568,325
• Publication Number:
  US 20070216410A1
• Time in Patent Office: 1,427 Days
• Field of Search: 324300-322, 600407-445
• US Class Current: 324/307
• CPC Class Codes: G01R 33/4804 Spatially selective measurement of temperature or pH

Abstract

A magnetic resonance imaging system (1) includes a data acquisition system (11) with a main magnet (12) with an imaging volume. A gradient system (G) generates field gradients (Gx), (Gy) and (Gz). An RF excitation system (10) generates radio-frequency (RF) excitation pulses. In a receiving mode, an RF coil senses a response, for example in the form of free induction decay signals, including echo signals. An image processor (26) is arranged to extract thermometry data and longitudinal relaxation time data from the acquired MR signals and to forward corresponding reconstructed images to a display unit (28).

Claims

1. A magnetic resonance imaging system comprising:

a data acquisition system including;

a main magnet which generates a magnetic field in an imaging volume,

a gradient system which generates a gradient in said magnetic field;

an RF excitation system which generates a radio-frequency wave in the imaging volume, said radio-frequency wave being configured to interact with a contrast agent encapsulated in a thermo-sensitive shield introduced into matter, positioned in the imaging volume;

a signal acquisition system which detects a signal representative of a response of the matter and contrast agent to said radio-frequency wave;

a control system which controls the data acquisition system to generate a dataset including signal phase data and signal magnitude data;

an image processor which reconstructs based on the dataset, an image representative of;

(1) local thermometry data and (2) local longitudinal relaxation data using said phase data and said magnitude data and which generates a further signal upon an event of a detection of the contrast agent outside the shield.

2. The magnetic resonance imaging system according to claim 1, wherein said system further comprises:

a heating device arranged to locally elevate a temperature in the matter, said magnetic resonance imaging system being further arranged to monitor the local thermometry data in the matter and to control the heating device in accordance with a pre-set control program.

3. The magnetic resonance imaging system according to claim 2, further including:

a control program comprises a set of instructions for controlling a heating mode.

4. The magnetic resonance imaging system according to claim 3, wherein said heating device is arranged to elevate the local temperature within the matter in a spot, said control program comprising a further set of instructions for controlling a position of said spot.

5. The magnetic resonance imaging system according to claim 1, wherein said system is further arranged to monitor a change in the signal magnitude data and to generate the further signal representative of said change.

6. The magnetic resonance imaging system according to claim 1, wherein said contrast agent is associated with a pharmaceutical to be transported to a target within the matter, a transport of the pharmaceutical being monitored by the image processor based on said signal magnitude data.

7. A method of magnetic resonance imaging comprising

positioning an object to be investigated in an imaging volume of a magnetic resonance apparatus, the object comprising a contrast agent encapsulated in a thermo-sensitive shield, said shield being configured to increase its permeability to the contrast agent and/or to surrounding water upon an event of a threshold temperature being reached;

acquiring a magnetic resonance dataset representative of temperature data and longitudinal relaxation data of the matter object;

reconstructing an image representative of said temperature data and said longitudinal relaxation data;

heating region of the object using a heating device at least until a threshold temperature is reached;

detecting an event of the contrast agent leaving the shield.

8. The method according to claim 7, wherein the method further comprises:

controlling the heating device in accordance with the temperature data and/or the longitudinal relaxation data.

9. A computer readable medium containing computer instructions for controlling the magnetic resonance apparatus to perform the method according to claim 7.

10. A computer readable medium according to claim 9, wherein said computer instructions control the heading device in accordance with the local temperature data and/or the local longitudinal relaxation data.

11. A magnetic resonance imaging system comprising:

a data acquisition system including;

a main magnet configured to generate a magnetic field in an imaging volume,

a gradient system configured to generate gradients in the magnetic field in the imaging volume;

an RF excitation system configured to transmit radio-frequency excitation signals in the imaging volume;

a signal acquisition system configured to detect radio-frequency response signals from a subject in the imaging volume in response to the radio-frequency excitation signals;

a control system configured to operate the data acquisition system to generate from the response signals a dataset including signal phase data and signal magnitude data;

an image processing system configured to reconstruct based on said dataset an image representative of (1) local thermometry data and (2) local longitudinal relaxation data using said phase data and said magnitude data;

a heating device configured to locally elevate a temperature in at least one subregion of the subject;

the control system further being configured to monitor the local thermometry data in the subject and to control the heating device to control heating of the at least one subregion of the subject in accordance with a pre-set control program.

12. The magnetic resonance imaging system according to claim 11, wherein the control program controls at least one of a temperature and a position of the at least one subregion of the subject.

13. The magnetic resonance imaging system according to claim 11, wherein at least one of a thermo-sensitive pharmaceutical and a thermo-sensitive contrast agent are injected into the subject and the image processing system reconstructs the signal phase data into an image representative of the local thermometry and the signal magnitude data into an image representative of a distribution or location of the thermo-sensitive pharmaceutical or contrast agent.

14. A method of magnetic resonance imaging comprising:

acquiring a magnetic resonance dataset from a subject positioned in an imaging volume of a magnetic resonance apparatus from a subject, which subject has received a thermo-sensitive substance, the dataset being indicative of a temperature distribution in the subject and a longitudinal relaxation distribution in the subject;

reconstructing an image representative of the temperature distribution and at least one of the longitudinal relaxation distribution and a thermo-sensitive substance distribution in the subject.

15. The method according to claim 14, wherein the thermo-sensitive substance is one of a thermo-sensitive contrast agent and a thermo-sensitive pharmaceutical.

16. A magnetic resonance imaging apparatus including at least one processor programmed to control the magnetic resonance imaging apparatus to perform the method according to claim 14.

17. A computer readable medium carrying program code for controlling a computer to perform the method according to claim 14.