Automatic capture verification using electrocardiograms sensed from multiple implanted electrodes
First Claim
1. A method of classifying a cardiac response to one or more pacing pulses, comprising:
- sensing one or more intrinsic composite cardiac signals, each intrinsic composite cardiac signal indicative of intrinsic cardiac activity and sensed using at least three spatially distributed implantable electrodes;
performing source separation using the sensed one or more intrinsic composite cardiac signals, the source separation separating one or more components of the intrinsic composite signal according to correlation between components of common cardiac origin;
producing one or more intrinsic cardiac signal vectors representative of all or a portion of one or more intrinsic cardiac activation sequences based on the separated one or more components of the intrinsic composite cardiac signal;
sensing one or more paced composite cardiac signals, each paced composite cardiac signal indicative of cardiac activity following delivery of pacing energy and sensed using at least three spatially distributed implantable electrodes;
performing source separation using the sensed one or more paced composite cardiac signals, the source separation separating one or more components of the paced composite signal according to correlation between components of common cardiac origin;
producing one or more paced cardiac signal vectors representative of all or a portion of one or more cardiac activation sequences based on the separated one or more components of the paced composite signal;
establishing a vector orientation criterion based on respective orientations of the one or more intrinsic cardiac signal vectors and the one or more paced cardiac signal vectors;
delivering a cardiac pacing pulse;
sensing one or more composite cardiac signals following delivery of the cardiac pacing pulse using at least three spatially distributed implantable electrodes;
performing source separation using the sensed one or more composite cardiac signals, the source separation separating one or more components of the composite cardiac signal according to correlation between components of common cardiac origin;
producing one or more cardiac signal vectors representative of all or a portion of one or more cardiac activation sequences based on the separated one or more components of the composite cardiac signal; and
classifying a cardiac response to the pacing pulse as capture or non-capture based on at least a comparison of orientation of the one or more cardiac signal vectors with the vector orientation criterion.
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Abstract
Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed for automatic capture verification using cardiac activation sequence information. Devices and methods sense composite cardiac signals using implantable electrodes. A source separation is performed using the composite signals. One or more signal vectors are produced that are associated with all or a portion of one or more cardiac activation sequences based on the source separation. A cardiac response to the pacing pulses is classified using characteristics associated with cardiac signal vectors and the signals associated with the vectors. Further embodiments may involve classifying the cardiac response as capture or non-capture, fusion or intrinsic cardiac activity. The characteristics may include an angle or an angle change of the cardiac signal vectors, such as a predetermined range of angles of the one or more cardiac signal vectors.
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Citations
21 Claims
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1. A method of classifying a cardiac response to one or more pacing pulses, comprising:
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sensing one or more intrinsic composite cardiac signals, each intrinsic composite cardiac signal indicative of intrinsic cardiac activity and sensed using at least three spatially distributed implantable electrodes; performing source separation using the sensed one or more intrinsic composite cardiac signals, the source separation separating one or more components of the intrinsic composite signal according to correlation between components of common cardiac origin; producing one or more intrinsic cardiac signal vectors representative of all or a portion of one or more intrinsic cardiac activation sequences based on the separated one or more components of the intrinsic composite cardiac signal; sensing one or more paced composite cardiac signals, each paced composite cardiac signal indicative of cardiac activity following delivery of pacing energy and sensed using at least three spatially distributed implantable electrodes; performing source separation using the sensed one or more paced composite cardiac signals, the source separation separating one or more components of the paced composite signal according to correlation between components of common cardiac origin; producing one or more paced cardiac signal vectors representative of all or a portion of one or more cardiac activation sequences based on the separated one or more components of the paced composite signal; establishing a vector orientation criterion based on respective orientations of the one or more intrinsic cardiac signal vectors and the one or more paced cardiac signal vectors; delivering a cardiac pacing pulse; sensing one or more composite cardiac signals following delivery of the cardiac pacing pulse using at least three spatially distributed implantable electrodes; performing source separation using the sensed one or more composite cardiac signals, the source separation separating one or more components of the composite cardiac signal according to correlation between components of common cardiac origin; producing one or more cardiac signal vectors representative of all or a portion of one or more cardiac activation sequences based on the separated one or more components of the composite cardiac signal; and classifying a cardiac response to the pacing pulse as capture or non-capture based on at least a comparison of orientation of the one or more cardiac signal vectors with the vector orientation criterion. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A cardiac system adapted to facilitate classification of a cardiac response to a pacing pulse, comprising:
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a plurality of implantable electrodes configured for sensing a composite signal, thereby providing a plurality of sensed composite cardiac signals; a housing configured for implantation in a patient; a controller configured to receive signals sensed by the implantable electrodes;
memory; anda signal processor in communication with the memory, at least one of the controller and the signal processor configured to execute stored program instructions to cause the cardiac system to; perform a source separation for each composite cardiac signal of the plurality of sensed composite cardiac signals by separating one or more components of each composite cardiac signal of the plurality according to correlation between components of common cardiac origin, the plurality of composite cardiac signals comprising an intrinsic composite cardiac signal not associated with pacing energy delivery, a paced composite cardiac signal sensed following delivery of pacing energy, and a capture composite cardiac signal sensed following delivery of a pacing pulse, each source separation producing one or more cardiac signal vectors associated with all or a portion of a respective one of a plurality of cardiac activation sequences; establish a vector orientation criterion based on respective orientations of the cardiac signal vectors produced from the source separations of the intrinsic composite cardiac signal and the paced composite cardiac signal; compare orientation of the one or more cardiac signal vectors produced from the source separation of the capture composite cardiac signal with the vector orientation criterion; and classify the cardiac response to the pacing pulse as capture or non-capture using the comparison of the one or more cardiac signal vectors and the vector orientation criterion. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19)
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20. An implantable cardiac device, comprising:
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means for sensing a plurality of composite cardiac signals using a plurality of implantable cardiac electrodes; means for performing a respective source separation for each of a plurality of sensed composite cardiac signals by separating one or more components of each composite cardiac signal of the plurality according to correlation between components of common cardiac origin, the plurality of sensed composite cardiac signals comprising an intrinsic composite signal not associated with pacing energy delivery, a paced composite cardiac signal sensed following delivery of pacing energy, and a capture composite cardiac signal sensed following delivery of a pacing pulse, each source separation producing one or more cardiac signal vectors associated with all or a portion of a respective one of a plurality of cardiac activation sequences; means for establishing a vector orientation criterion based on respective orientations of the cardiac signal vectors produced from the source separation of the intrinsic composite signal and the paced composite signal; means for comparing orientation of the one or more cardiac signal vectors produced from the source separation of the capture composite signal with the vector orientation criterion; and means for classifying the cardiac response to the pacing pulse as capture or non-capture using the comparison of the one or more cardiac signal vectors and the vector orientation criterion the one or more cardiac signal vectors. - View Dependent Claims (21)
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Specification