Optimized method for LID biosensor resonance detection
First Claim
1. An optical interrogation system comprising:
- a launch system that emits an optical beam towards a biosensor;
a receive system that collects an optical beam from the biosensor and then outputs a signal which is representative of the collected optical beam; and
a processor that reduces pixelation oscillations in an optical resonance of the signal by oversampling at least a portion of the optical resonance, smoothing if needed the optical resonance and calculating a resonance location or centroid that is based on the smoothed-oversampled optical resonance.
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Abstract
An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using a low pass filter algorithm to digitally remove problematic parasitic reflections contained in the spectrum of an optical resonance which makes it easier to determine whether or not a biological event occurred on the biosensor. In another embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor.
15 Citations
14 Claims
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1. An optical interrogation system comprising:
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a launch system that emits an optical beam towards a biosensor; a receive system that collects an optical beam from the biosensor and then outputs a signal which is representative of the collected optical beam; and a processor that reduces pixelation oscillations in an optical resonance of the signal by oversampling at least a portion of the optical resonance, smoothing if needed the optical resonance and calculating a resonance location or centroid that is based on the smoothed-oversampled optical resonance. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method for interrogating a biosensor, said method comprising the steps of:
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emitting an optical beam towards a biosensor; collecting an optical beam from the biosensor generating a signal which corresponds to the collected optical; and reducing oscillations in an optical resonance of the signal caused by a problematical pixelation effect by; oversampling at least a portion of the optical resonance; smoothing if needed the optical resonance; and calculating a resonance location or centroid that is based on the smoothed-oversampled optical resonance. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14)
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Specification