Preparing peptide spectra for identification
First Claim
1. A method for preparing peptide spectra for identification, the method comprising:
- a) populating a matrix with a plurality of clusters of a plurality of peptide spectra, wherein each of said clusters is represented in both a different row of said matrix and a different column of said matrix, thereby resulting in a symmetric matrix;
b) finding the minimum of each of said clusters in said matrix;
c) populating a vector with said minima of said clusters wherein each element in said vector corresponds to one of said clusters;
d) finding the global minimum of said matrix as being the minimum of said vector;
e) merging two of said clusters identified by said global minimum into a merged cluster; and
f) providing said merged cluster for identification of at least one peptide associated with said merged cluster.
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Abstract
A method for preparing peptide spectra for identification, the method including constructing a symmetric distance matrix from a plurality of peptide spectra, where a cluster of at least one of the spectra is represented in a row of the matrix, and where the cluster is also represented in a column of the matrix, finding the minimum of each of the clusters in the matrix, constructing a vector from the minima where each element in the vector corresponds to one of the clusters, finding the global minimum of the matrix as being the minimum of the vector, merging two of the clusters identified by the global minimum into a merged cluster, and providing the merged cluster for identification of at least one peptide associated with the merged cluster.
8 Citations
8 Claims
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1. A method for preparing peptide spectra for identification, the method comprising:
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a) populating a matrix with a plurality of clusters of a plurality of peptide spectra, wherein each of said clusters is represented in both a different row of said matrix and a different column of said matrix, thereby resulting in a symmetric matrix; b) finding the minimum of each of said clusters in said matrix; c) populating a vector with said minima of said clusters wherein each element in said vector corresponds to one of said clusters; d) finding the global minimum of said matrix as being the minimum of said vector; e) merging two of said clusters identified by said global minimum into a merged cluster; and f) providing said merged cluster for identification of at least one peptide associated with said merged cluster. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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Specification