Boronic chalcone derivatives and uses thereof

• US 7,514,579 B2
• Filed: 06/12/2003
• Issued: 04/07/2009
• Est. Priority Date: 06/13/2002
• Status: Expired due to Fees

• Current Assignee: Johns Hopkins University, Johns Hopkins Technology Transfer
• Original Assignee: Johns Hopkins Technology Ventures, Johns Hopkins University
• Inventors: Khan, Saeed R.
• Primary Examiner(s): Sullivan; Daniel M
• Assistant Examiner(s): Nwaonicha; Chukwuma O
• Application Number:
  US10/517,781
• Publication Number:
  US 20050176988A1
• Time in Patent Office: 2,126 Days
• Field of Search: 562/7
• US Class Current: 562/7
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/04 specific for metastasis
• CPC Class Codes: C07F 5/025 Boronic and borinic acid compounds

Abstract

The present invention relates to novel boronic chalcone derivatives which are useful as antitumor/anticancer agents. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good inhibitors of the growth of human breast cancer cells. The present invention also relates to the use of the novel boronic chalcone derivatives to treat cancer. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of cancer.

Claims

1. A compound of Formula (I):

2. The compound of claim 1 having the structure

3. The compound of claim 1 having the structure

4. The compound of claim 1 having the structure

5. The compound of claim 1 having the structure

6. The compound of claim 1 having the structure

7. The compound of claim 1 having the structure

8. The compound of claim 1 having the structure

9. The compound of claim 1 having the structure

10. A method of treating breast cancer in a patient in need thereof comprising administering to said patient an effective amount of a compound of Formula (I):