Photoacoustic analyzer of region of interest in a human body

• US 7,515,948 B1
• Filed: 09/13/2004
• Issued: 04/07/2009
• Est. Priority Date: 09/12/2003
• Status: Expired due to Fees

• Current Assignee: OrNim, Inc.
• Original Assignee: OrNim, Inc.
• Inventors: Balberg, Michal, Shechter, Revital Pery, Olshansky, Michal
• Primary Examiner(s): Winakur; Eric F
• Assistant Examiner(s): Berhanu; Etsub D
• Application Number:
  US10/938,880
• Time in Patent Office: 1,667 Days
• Field of Search: 600/310, 600/323, 600/407, 600/473, 600/476
• US Class Current: 600/323
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 5/02411 of foetuses
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/1464 specially adapted for foetal tissue
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61B 7/00 Instruments for auscultation

Abstract

A method and apparatus are presented for non-invasively monitoring at least one characteristic of a region of interest in a body. The body is illuminated by pulsed light to induce a photoacoustic effect. Acoustic radiation is detected, and measured data indicative thereof is generated. The photoacoustic effect is controlled by carrying out at least one of the following: providing the pulsed light of at least two different wavelength, analyzing the measured data to determine time variations of at least one predetermined parameter of a time dependent acoustic signal for each of wavelength, and determining oxygen saturation level in the region of interest; and operating a plurality of acoustic elements configured for detection of the acoustic radiation, to thereby define a focal volume for acoustic radiation detection to match dimensions of the region of interest.

Claims

1. A device for non-invasive analysis in a region of interest of a body medium, the device comprising:

(a) an illuminator configured to produce pulsed light of at least two different wavelengths;

(b) an acoustic unit configured and operable to collect acoustic radiation and generate data indicative thereof, the acoustic unit being operable to collect acoustical radiation at a location on a body surface generated in the region of interest by a photoacoustic effect when the region of interest is irradiated with the illuminating pulsed light and generate measured data indicative of the received radiation; and

(c) a processor configured to receive the measured data, and analyze the received data to determine at least one desired characteristic of the region of interest, said at least one desired parameter comprising a cross-sectional dimension of the region of interest, the processor being preprogrammed to carry out at least one of the following;

i) determining time variations of at least one predetermined parameter of a time dependent acoustic signal in the collected acoustic radiation for each of said at least two wavelengths, and determining oxygen saturation level in the region of interest;

ii) operating a plurality of acoustic elements of the acoustic unit to thereby define a focal volume for the acoustic radiation collection, said focal volume matching dimensions of the region of interest.

2. The device according to claim 1(ii), wherein the processor is configured to selectively activate the acoustic elements according to a predetermined temporo-spatial pattern.

3. The device according to claim 2, wherein the processor is configured to process the measured data by sampling signals generated by the acoustic elements according to the predetermined temporo-spatial pattern.

4. The device according to claim 1 (ii), wherein the processor is configured to process the measured data by sampling signals generated by the acoustic elements according to a predetermined temporo-spatial pattern.

5. The device of claim 4, wherein the processor is operable to collect signals from the acoustic elements operating desired dimensions of the focal volume defined by a distance between a center of the region of interest and the acoustic unit and a cross-sectional dimension of the region of interest.

6. The device according to claim 5, wherein the processor is operable to process signals generated by the plurality of the acoustic elements to collect the signals associated with a circular region having a diameter D satisfying D=2.44λ

_sL/d, where λ

s is a characteristic wavelength of the acoustic radiation in the region of interest, L defines a distance between the center of the region of interest and the acoustic unit; and

d defines the cross-sectional dimension of the region of interest.

7. The device according to claim 5, wherein the processor is operable to process signals generated by the plurality of the acoustic elements to collect the signals associated with a rectangular region having a small width D satisfying D=2λ

_sL/d, where λ

s is a characteristic wavelength of the acoustic radiation in the region of interest, L defines the distance between the center of the region of interest and the acoustic unit, and d defines the cross-sectional dimension of the region of interest.

8. The device of claim 1, wherein the acoustic unit comprises a phased array of the acoustic elements.

9. The device of claim 1(ii), wherein the acoustic elements are configured as a phased array.

10. The device of claim 1(i), wherein the acoustic unit comprises at least one acoustic element.

11. The device of claim 1(ii), wherein the processor is operable to selectively activate the acoustic elements such that the activated acoustic elements operate desired dimensions of the focal volume defined by a distance between a center of the region of interest and the acoustic unit and a cross-sectional dimension of the region of interest.

12. The device according to claim 11, wherein the processor is operable to selectively activate the acoustic elements such that the activated acoustic elements form a circular region having a diameter D satisfying D=2.44λ

_sL/d, where λ

s is a characteristic wavelength of the acoustic radiation in the region of interest, L defines a distance between the center of the region of interest and the acoustic unit; and

d defines the cross-sectional dimension of the region of interest.

13. The device according to claim 11, wherein the processor is operable to selectively activate the acoustic elements such that the activated acoustic elements form a rectangular region having a small width D satisfying D=2λ

_sL/d, where λ

s is a characteristic wavelength of the acoustic radiation in the region of interest, L defines a distance between the center of the region of interest and the acoustic unit, and d defines the cross-sectional dimension of the region of interest.

14. The device according to claim 1(ii), wherein the plurality of the acoustic elements are arranged in concentric arrays.

15. The device according to claim 1(ii), wherein the plurality of the acoustic elements are arranged in a two-dimensional array.

16. The device according to claim 1, wherein the processor is configured to extract, from the measured data, a data portion indicative of the acoustic radiation generated in the region of interest.

17. The device according to claim 1, wherein the processor is configured to operate the acoustic unit at a certain time after the illumination was initiated to thereby collect the acoustic radiation substantially from the region of interest.

18. The device according to claim 1, wherein the illuminator is configured and operable to produce the pulses of the different wavelengths at different times.

19. The device according to claim 1(i), wherein the processor is configured to extract, from the measured data, a data portion indicative of the acoustic radiation produced in the region of interest, and determine the time variations of at least one of amplitude and transient slope parameters of the time dependent acoustic signal produced in the region of interest.

20. The device according to claim 19, wherein the processor is configured to determine a difference between maximal and minimal values of said at least one parameter over a cardiac cycle.

21. The device according to claim 20, wherein the processor is configured to determine oxygen saturation level in the region of interest.

22. The device according to claim 1, configured for the non-invasive analysis of a fetus condition.

23. The device according to claim 1, configured for the non-invasive analysis of at least one of the oxygen saturation level in the region of interest, and an amniotic fluid composition.

24. The device according to claim 1, configured for the non-invasive analysis of a fetal blood oxygen saturation.

25. The device according to claim 1, configured for the non-invasive analysis of a maternal oxygen saturation level of a gravida.

26. The device according to claim 1, configured for the non-invasive analysis of an oxygen saturation level of a mammal.

27. The device of claim 1, where the two different wavelengths are selected as those differently absorbable by oxygenated and deoxygenated hemoglobin in the body.

28. The device according to claim 27, wherein the first wavelength is in a range of about 605-805 nm and the second wavelength is in a range of about 800-1300 nm.

29. The device of claim 1, where the two different wavelengths are selected as those characterized by the same absorption by tissue or fluid components in the body.

30. The device of claim 29, where the two different wavelengths are selected to be differently scattered by tissue or fluid components in the body.

31. The device according to claim 1, configured as an oximeter or pulse oximeter.

32. The device according to claim 1, configured for determining a relative location of the region of interest relative to the acoustic unit.

33. The device according to claim 1, configured for determining a distance between the center of the region of interest and the acoustic unit.

34. The device according to claim 1, comprising an imaging system for imaging the region of interest.

35. The device according to claim 1, comprising an acoustic imaging system for imaging the region of interest.

36. The device according to claim 35, wherein said acoustic imaging system includes said acoustic unit for detecting the photoacoustic effect.

37. A device for non-invasive analysis of a region of interest in a body medium, the device comprising:

(a) an illumination unit producing pulsed light;

(b) an acoustic unit configured to collect acoustic radiation and generate measured data indicative thereof, the acoustic unit comprising a plurality of independent acoustic elements, each acoustic element producing a measured signal in response to and indicative of collected acoustic radiation at a location on a body surface generated in the body medium by a photoacoustic effect when the acoustic unit is applied to the body surface and the body medium is irradiated with the illuminating light; and

(c) a processor configured to operate the acoustic unit to thereby define a focal volume for the acoustic radiation collection to match dimensions of the region of interest and to determine a cross-sectional dimension of the region of interest.

38. The device according to claim 37, wherein the processor is configured for the operation of the acoustic unit by selectively actuating the acoustic elements to define the focal volume matching the region of interest.

39. The device according to claim 37 wherein the processor is configured for the operation of the acoustic unit by processing the measured data produced by the plurality of the acoustic element to define the focal volume matching the region of interest.

40. A device for non-invasive pulse oximetry in a region of interest of a body, the device comprising:

(a) an illumination unit configured and operable to produce pulsed light of at least two different wavelengths;

(b) an acoustic unit configured to generate data indicative of received acoustic radiation, the acoustic unit being operable to receive acoustical radiation at a location on a body surface generated in the region of interest by a photoacoustic effect when the region of interest is irradiated with the illuminating pulsed light and generate measured data indicative of the received radiation; and

(c) a processor configured to receive and analyze the measured data, to determine time variations of at least one predetermined parameter of the time dependent acoustic signal for each of said at least two wavelengths, and determine a cross-sectional dimension of the region of interest and determine oxygen saturation level in the region of interest.