Biological parameter output apparatus and program

• US 7,516,017 B2
• Filed: 08/22/2005
• Issued: 04/07/2009
• Est. Priority Date: 08/26/2004
• Status: Expired due to Fees

• Current Assignee: Kyoto University
• Original Assignee: Kyoto University
• Inventors: Kawano, Hiroyuki, Hido, Shohei, Noma, Akinori, Sarai, Nobuaki
• Primary Examiner(s): Le; John H
• Application Number:
  US11/660,746
• Publication Number:
  US 20070255504A1
• Time in Patent Office: 1,324 Days
• Field of Search: 702/19, 702/21, 702 70- 71, 702/189, 600/300, 600/481, 600/512, 600/547, 435/287.1, 128/734, 128/735
• US Class Current: 702/19
• CPC Class Codes: G06F 18/00 Pattern recognition
• CPC Class Codes: G06F 2218/00 Aspects of pattern recognition specially adapted for signal processing

Abstract

It is an object of the invention to measure the change in action potential waveforms during administration of a drug by testing in cultured cells or in animals, and using this measurement to evaluate the influence of administration of the drug on biological parameters, thereby providing an approach to evaluating the effect on individual channels of a cell. The invention provides a biological parameter output apparatus that contains at least one piece of waveform information that includes at least one piece of biological parameter information, which is a set of a biological parameter identifier and a biological parameter value, and action potential waveform information, receives input of action potential waveform information, acquires at least one piece of biological parameter information based on the action potential waveform information, and outputs the at least one biological parameter information acquired. With this biological parameter output apparatus, it is possible to evaluate the effect on individual channels of a cell.

Claims

1. A biological parameter output apparatus, comprising:

a waveform information storage portion that contains at least one piece of waveform information that includes action potential waveform information that has been acquired by receiving a biological parameter set including at least one piece of biological parameter information, which is a set of biological parameter identifier for identifying at least one parameter selected from a current flowing through various channels of a cell, an opening and closing speed of each of the channels, ion affinity, and intracellular and extracellular ion concentrations, and a biological parameter value, which is a value of the biological parameter identified by the biological parameter identifier, inputting the biological parameter set to a model, and performing a simulation using the model, and the biological parameter set;

a waveform information receiving portion that receives input of action potential waveform information, which is information relating to an action potential waveform measured from a biological body before administration of a drug, and action potential waveform information, which is information relating to an action potential waveform measured from the biological body after administration of the drug;

a biological parameter information acquisition portion that identifies and acquires two biological parameter sets before administration of the drug and after administration of the drug, respectively, using a portion or all of the waveform information in the waveform information storage portion and the two different pieces of action potential waveform information received by the waveform information receiving portion; and

a biological parameter information output portion that outputs the two biological parameter sets acquired by the biological parameter information acquisition portion.

2. A biological parameter output apparatus, comprising:

a simulation apparatus that receives a biological parameter set including at least one piece of biological parameter information, which is a set of a biological parameter identifier for identifying at least one parameter selected from a current flowing through various channels of a cell, an opening and closing speed of each of the channels, ion affinity, and intracellular and extracellular ion concentration, and a biological parameter value, which is a value of the biological parameter identified by the biological parameter identifier, inputs the biological parameter set to a model, and acquires action potential waveform information using the model,

a waveform information receiving portion that receives input of action potential waveform information, which is information relating to an action potential waveform information measured from a biological body before administration of a drug, and action potential waveform information, which is information relating to an action potential waveform measured from the biological body after administration of the drug;

a biological parameter information acquisition portion that identifies and acquires two biological parameter sets before administration of the drug and after administration of the drug, respectively, using a portion or all of waveform information that includes the action potential waveform information acquired by the simulation apparatus and the biological parameter set received by the simulation apparatus, and the two different pieces of action potential waveform information received by the waveform information receiving portion; and

a biological parameter information output portion that outputs the two biological parameter sets acquired by the biological parameter information acquisition portion.

3. A biological parameter output method that is realized with a waveform information receiving portion, a biological parameter information acquisition portion, and a biological parameter information output portion, the method comprising:

a waveform information receiving step of receiving, by the waveform information receiving portion, input of action potential waveform information, which is information relating to an action potential waveform measured from a biological body before administration of a drug, and action potential waveform information, which is information relating to an action potential waveform measured from the biological body after administration of the drug;

a biological parameter information acquisition step of identifying, acquiring and storing in a storage medium, by the biological parameter information acquisition portion, two biological parameter sets before administration of the drug and after administration of the drug, respectively, using a portion or all of the waveform information that is stored and the two different pieces of action potential waveform information received in the waveform information receiving step; and

a biological parameter information output step of outputting, by the biological parameter information output portion, the biological parameter sets on the storage medium.

4. A biological parameter output method that is realized with a simulation apparatus, a waveform information receiving portion, a biological parameter information acquisition portion, and a biological parameter information output portion, the method comprising:

a simulation step of receiving, by the simulation apparatus, a biological parameter set including at least one piece of biological parameter information, which is a set of biological parameter identifier for identifying at least one parameter selected from a current flowing through various channels of a cell, an opening and closing speed of each of the channels, ion affinity, and intracellular and extracellular ion concentrations, and a biological parameter value, which is a value of the biological parameter identified by the biological parameter identifier, inputting the biological parameter set to a model, and acquiring action potential waveform information using the model,

a waveform information receiving step of receiving, by the waveform information receiving portion, input of action potential waveform information, which is information relating to an action potential waveform measured from a biological body before administration of a drug, and action potential waveform information, which is information relating to an action potential waveform measured from the biological body after administration of the drug;

a biological parameter information acquisition step of identifying and acquiring, by the biological parameter information acquisition portion, two biological parameter sets before administration of the drug and after administration of the drug, respectively, using a portion or all of waveform information that includes the action potential waveform information acquired in the simulation step and the biological parameter set received in the simulation step, and the two different pieces of action potential waveform information received in the waveform information receiving step; and

a biological parameter information output step of outputting, by the biological parameter information output portion, the two biological parameter sets acquired in the biological parameter information acquisition step.

5. A program product stored in a computer readable medium, that permits a computer to implement the following steps:

a waveform information receiving step of receiving input of action potential waveform information, which is information relating to an action potential waveform measured from a biological body before administration of a drug, and action potential waveform information, which is information relating to an action potential waveform measured from the biological body after administration of the drug;

a biological parameter information acquisition step of reading, from a storage medium that contains at least one piece of waveform information that includes action potential waveform information that has been acquired by receiving a biological parameter set including at least one piece of biological parameter information, which is a set of a biological parameter identifier for identifying at least one parameter selected from a current flowing through various channels of a cell, an opening and closing speed of each of the channels, ion affinity, and intracellular and extracellular ion concentrations, and a biological parameter value, which is a value of the biological parameter identified by the biological parameter identifier, inputting the biological parameter set to a model, and performing a simulation using the model, and the biological parameter set, two biological parameter sets before administration of the drug and after administration of the drug, respectively, using a portion or all of the waveform information and the two different pieces of action potential waveform information received in the waveform information receiving step, identifying, acquiring and storing in a storage medium the two biological parameter sets; and

a biological parameter information output step of outputting the two biological parameter sets acquired by the biological parameter information acquisition step.

6. A program product stored in a computer readable medium, that permits a computer to implement the following steps:

a simulation step of receiving a biological parameter set including at least one piece of biological parameter information, which is a set of a biological parameter identifier for identifying at least one parameter selected from a current flowing through various channels of a cell, an opening and closing speed of each of the channels, ion affinity, and intracellular and extracellular ion concentrations, and a biological parameter value, which is a value of the biological parameter identified by the biological parameter identifier, inputting the biological parameter set to a model, and acquiring action potential waveform information using the model,

a waveform information receiving step of receiving input of action potential waveform information, which is information relating to an action potential waveform measured from a biological body before administration of a drug, and action potential waveform information, which is information relating to an action potential waveform measured from the biological body after administration of the drug;

a biological parameter information acquisition step of identifying and acquiring two biological parameter sets before administration of the drug and after administration of the drug, respectively, using a portion or all of waveform information that includes the action potential waveform information acquired in the simulation step and the biological parameter set received in the simulation step, and the two different pieces of action potential waveform information received in the waveform information receiving step; and

a biological parameter information output step of outputting the two biological parameter sets acquired in the biological parameter information acquisition step.