Noninvasive analyzer sample probe interface method and apparatus
First Claim
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1. A method for noninvasive estimation of a tissue sample property, comprising the steps of:
- providing an analyzer, wherein said analyzer comprises;
a sample probe coupled to said analyzer, said sample probe being movable with respect to said analyzer, and said sample probe having a tip;
displacing at least a portion of said tissue sample with said sample probe;
collecting a set of time serial spectral data of said tissue sample at least during said step of displacing;
selecting a sub-set of said set of spectra, wherein sampling precision is enhanced; and
estimating said tissue sample property using said sub-set.
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Abstract
A method and apparatus are provided for noninvasive sampling. More particularly, the method and apparatus relate to control of motion of an optical sample probe interface relative to a tissue sample site. A dynamic probe interface, is used to collect spectra of a targeted sample, control positioning of the sample probe relative to the tissue sample in terms of at least one of x-, y-, and z-axes, and/or control of sample tissue displacement to minimize spectral variations resulting from the sampling process and increase analyte property estimation precision and accuracy.
423 Citations
26 Claims
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1. A method for noninvasive estimation of a tissue sample property, comprising the steps of:
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providing an analyzer, wherein said analyzer comprises; a sample probe coupled to said analyzer, said sample probe being movable with respect to said analyzer, and said sample probe having a tip; displacing at least a portion of said tissue sample with said sample probe; collecting a set of time serial spectral data of said tissue sample at least during said step of displacing; selecting a sub-set of said set of spectra, wherein sampling precision is enhanced; and estimating said tissue sample property using said sub-set. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for determining a blood/tissue analyte concentration, comprising the steps of:
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providing a noninvasive analyzer, comprising; a sample probe, wherein at least part of said sample probe is movable relative to said analyzer; iteratively collecting a positioning spectrum at a first rate; using at least a portion of said positioning spectrum to establish contact of said sample probe with said tissue; collecting a set of spectra at a second rate; and using at feast a portion of said set of spectra to estimate said analyte property. - View Dependent Claims (9, 10)
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11. An apparatus for spectroscopic noninvasive measurement of a tissue sample, comprising:
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a noninvasive analyzer; a sample probe coupled to said analyzer; means for moving at least part of said sample probe along any of x-, y-, and z-axes means for acquisition of at least one spectrum while said sample probe is moving; and at least one algorithm for analysis of said spectrum, wherein said at least one algorithm provides for iterative control of said means for moving and said means for acquisition of said spectrum. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A method for analyte property estimation of a tissue sample, comprising the steps of:
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providing an analyzer, comprising; a sample probe having a sample probe tip; dispensing a coupling fluid on said tissue sample; iteratively controlling z-axis movement of said sample probe tip relative to said tissue sample to contact said sample probe tip with said coupling fluid; collecting at least one noninvasive spectrum of said tissue sample using said sample probe and said analyzer; using said spectrum as feedback in said step of iteratively controlling movement; and estimating said analyte property using said noninvasive spectrum. - View Dependent Claims (24, 25)
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26. An apparatus for spectroscopic noninvasive measurement of a tissue sample, comprising:
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a noninvasive analyzer; a sample probe coupled to said analyzer; means for moving at least part of said sample probe along at least one of x-, y-, and z-axes; means for acquisition of at least one spectrum while said sample probe is moving; and an algorithm for analysis of said spectrum, wherein said algorithm provides iterative control of said means for moving and said means for acquisition of said spectrum.
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Specification