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Method for elucidating reaction dynamics of photoreactive compounds from optical signals affected by an external magnetic field

  • US 7,519,411 B2
  • Filed: 09/26/2003
  • Issued: 04/14/2009
  • Est. Priority Date: 09/26/2003
  • Status: Active Grant
First Claim
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1. A method for elucidating reaction dynamics of photoreactive compounds in vivo, comprising the steps of:

  • a) turning on a probe beam;

    b) irradiating tissue within a region of interest (ROI) with the probe beam;

    c) recording fluorescence, phosphorescence and absorption characteristics of the tissue at at least one wavelength;

    d) administering a photoreactive agent to the ROI;

    e) irradiating the ROI with the probe beam;

    f) recording luminescence intensity and lifetime and absorption characteristics of the ROI at at least one wavelength when B =0 Tesla;

    g) applying a magnetic field of a predetermined strength to the ROI so that the combination of the magnetic field and irradiation induces a chemical reaction in said photoreactive agent;

    h) simultaneously recording the luminescence intensity and lifetime and absorption characteristics of the ROI at at least one wavelength when B>

    0 Tesla;

    i) repeating steps g) and h) for different magnetic field strengths;

    j) turning off said probe beam;

    k) processing the recorded data obtained in steps c), f) and h); and

    l) displaying the results obtained by said processing on a display.

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