Device and method for treatment of wounds with nitric oxide
First Claim
1. A method for wound bed preparation, the method comprising the steps of:
- diagnosing a wound site of a subject,providing a flow-controlled source of nitric oxide containing gas,debriding necrotic tissue located at the wound site by exposing the wound site, for a treatment period, to a high concentration of exogenous nitric oxide gas from the flow-controlled source of nitric oxide containing gas; and
exposing the wound to a low concentration of exogenous nitric oxide gas for a second treatment period sufficient to induce the expression of new collagen.
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Abstract
Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing of the wound and in preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used, for example, to reduce the microbial infection and burden on these wounds, manage exudate secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from about 160 to 400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide preferably ranging from about 5-20 ppm may to provided to restore the balance of nitric oxide and induce collagen expression to aid in the closure of the wound.
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Citations
9 Claims
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1. A method for wound bed preparation, the method comprising the steps of:
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diagnosing a wound site of a subject, providing a flow-controlled source of nitric oxide containing gas, debriding necrotic tissue located at the wound site by exposing the wound site, for a treatment period, to a high concentration of exogenous nitric oxide gas from the flow-controlled source of nitric oxide containing gas; and exposing the wound to a low concentration of exogenous nitric oxide gas for a second treatment period sufficient to induce the expression of new collagen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification