Method and system for colloid exchange therapy
First Claim
1. An extracorporeal blood filtration circuit for treating a patient'"'"'s blood to remove target molecules and target complex molecules, the circuit comprising:
- a line adapted to remove a portion of the patient'"'"'s blood, deliver the blood to a blood filter and to return a portion of the patient'"'"'s blood without being sieved;
a blood filter operably coupled with the line so as to allow the portion of the patient'"'"'s blood to flow therethrough, the blood filter operable to form a stream of filtered blood comprising the unsieved portion and a stream of ultrafiltrate with an ultrafiltration rate of between approximately two liters per hour and twenty liters per hour, the blood filter having a nominal molecular weight cutoff of greater than 150,000 Daltons and less than 1,000,000 Daltons so as to sieve more than a nominal amount of the target molecules and the target complex molecules from the portion of the patient'"'"'s blood and to avoid removal of significant amounts of immunoglobulins from the portion of the patient'"'"'s patient'"'"'s blood;
a source for infusing a replacement fluid into the blood circuit, the source including replacement fluid comprising clean target receptor molecules in sufficient amount so as to provide sufficient clean target receptor molecules to sequester inflammatory mediators and toxins from the patient'"'"'s tissue and to replace the target receptor molecules sieved from the portion of the patient'"'"'s blood by the blood filter, and sufficient albumin to maintain adequate plasma oncotic pressure with ultrafiltration rates between approximately two liters per hour and twenty liters per hour in a sufficient concentration to adequately replenish ongoing losses.
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Accused Products
Abstract
The present invention relates to a method and system for using a hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient'"'"'s blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patient'"'"'s blood and to infuse a replacement fluid into the patient'"'"'s blood to maintain a prescribed albumin concentration in the patient'"'"'s blood. The replacement fluid may include pharmaceutical grade balanced salt solution containing albumin and/or other target receptor molecules and/or other physiological molecules in a sufficient concentration to adequately replenish ongoing losses.
87 Citations
26 Claims
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1. An extracorporeal blood filtration circuit for treating a patient'"'"'s blood to remove target molecules and target complex molecules, the circuit comprising:
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a line adapted to remove a portion of the patient'"'"'s blood, deliver the blood to a blood filter and to return a portion of the patient'"'"'s blood without being sieved; a blood filter operably coupled with the line so as to allow the portion of the patient'"'"'s blood to flow therethrough, the blood filter operable to form a stream of filtered blood comprising the unsieved portion and a stream of ultrafiltrate with an ultrafiltration rate of between approximately two liters per hour and twenty liters per hour, the blood filter having a nominal molecular weight cutoff of greater than 150,000 Daltons and less than 1,000,000 Daltons so as to sieve more than a nominal amount of the target molecules and the target complex molecules from the portion of the patient'"'"'s blood and to avoid removal of significant amounts of immunoglobulins from the portion of the patient'"'"'s patient'"'"'s blood; a source for infusing a replacement fluid into the blood circuit, the source including replacement fluid comprising clean target receptor molecules in sufficient amount so as to provide sufficient clean target receptor molecules to sequester inflammatory mediators and toxins from the patient'"'"'s tissue and to replace the target receptor molecules sieved from the portion of the patient'"'"'s blood by the blood filter, and sufficient albumin to maintain adequate plasma oncotic pressure with ultrafiltration rates between approximately two liters per hour and twenty liters per hour in a sufficient concentration to adequately replenish ongoing losses. - View Dependent Claims (2, 3, 4, 5)
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6. A method for removing toxic substances from the blood of a patient, the method comprising:
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withdrawing blood from the patient; delivering the blood to a hemofilter having pores, the hemofilter characterized by a molecular weight cutoff of greater than 150,000 Daltons and less than 1,000,000 Daltons so as to create a return stream having retained molecules that did not pass through the pores and an ultrafiltrate characterized by having molecules that passed through the pores; removing at least a portion of the ultrafiltrate, so as to remove toxic substances contained in the ultrafiltrate from the blood; returning the return stream to the patient; and providing a fluid, containing clean target receptor molecules, to the patient. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification