Regeneration and repair of neural tissue using postpartum-derived cells
First Claim
1. A method of treating a patient having nerve pathology caused by traumatic nerve injury, said method comprising administering to the patient one or more cells, wherein said one or more cells are isolated from human postpartum umbilical cord substantially free of blood or are expanded in culture from a cell isolated from human postpartum umbilical cord substantially free of blood, in an amount effective to treat the nerve pathology, wherein said one or more cells self-renew and expand in culture and have the potential to differentiate into cells of at least a neural phenotype;
- require L-valine for growth;
can grow in at least about 5% oxygen;
do not produce CD117; and
exhibit increased expression, relative to a human fibroblast or mesenchymal stem cell, of an endogenous gene encoding oxidized low density lipoprotein receptor 1, interleukin 8, or reticulon 1.
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Abstract
Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.
257 Citations
17 Claims
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1. A method of treating a patient having nerve pathology caused by traumatic nerve injury, said method comprising administering to the patient one or more cells, wherein said one or more cells are isolated from human postpartum umbilical cord substantially free of blood or are expanded in culture from a cell isolated from human postpartum umbilical cord substantially free of blood, in an amount effective to treat the nerve pathology, wherein said one or more cells self-renew and expand in culture and have the potential to differentiate into cells of at least a neural phenotype;
- require L-valine for growth;
can grow in at least about 5% oxygen;
do not produce CD117; and
exhibit increased expression, relative to a human fibroblast or mesenchymal stem cell, of an endogenous gene encoding oxidized low density lipoprotein receptor 1, interleukin 8, or reticulon 1. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
- require L-valine for growth;
Specification