Compounds for use in weight loss and appetite suppression in humans

• US 7,524,877 B2
• Filed: 03/09/2006
• Issued: 04/28/2009
• Est. Priority Date: 11/20/2003
• Status: Expired due to Term

• Current Assignee: Savanna Health, LLC
• Original Assignee: Seroctin Research & Technologies
• Inventors: Rosenfeld, Mark J., Forsberg, Scott R.
• Primary Examiner(s): Weddington; Kevin E
• Application Number:
  US11/371,689
• Publication Number:
  US 20060148795A1
• Time in Patent Office: 1,146 Days
• Field of Search: 514/376, 514/374, 514/375, 514/909
• US Class Current: 514/376
• CPC Class Codes: A61K 31/423 condensed with carbocyclic rings
• CPC Class Codes: A61K 31/538 ortho- or peri-condensed with carbocyclic ring systems

Abstract

Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C₁-C₄ alkoxy group, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to act as weight loss agents, appetite suppressants mood enhancers and adjunctive therapy for arthritis, sleep apnea, fibromyalgia, diabetes and hyperglycemia. Additional chemical compounds of the present invention may include benzoxazinoids-cyclic hydroxyamic acids, lactams, and corresponding gluxosides, which may serve as precursors to phenolic compounds. The phenolic compounds and precursors of phenolic compounds of the present invention, at concentrations suitable for human therapeutic use, may be obtained from monocotyledonous plants such as corn in their early growth states which are timely harvested for optimum yield.

Claims

1. A process for promoting weight loss and/or suppressing appetite in a mammal by the administration of an amount of 6-methoxy-2,3-benzoxazolinone defined as:

2. A process as defined in claim 1, wherein said administered amount of said 6-methoxy-2,3-benzoxazolinone comprises a daily dosage of between about 5 mcg and about 60 mg.

3. A process as defined in claim 1, wherein said administered amount of said 6-methoxy-2,3-benzoxazolinone comprises a daily dosage of about 15 mg.

4. A process as defined in claim 1, wherein said 6-methoxy-2,3-benzoxazolinone is obtained at least in part from a leafy and/or immature plant part one or more monocotyledonous plants selected from the group consisting of corn, wheat, barley, rye, oats, rice, sorghum, millet, bamboo, Job'"'"'s Tears, barley-like grasses, and wild grasses.

5. A process as defined in claim 4, wherein said leafy and/or immature plant part is dried.

6. A process as defined in claim 5, wherein said leafy and/or immature plant part is dried at a temperature in the range of between about 40°

C. and about 45°

C.

7. A process as defined in claim 5, wherein said leafy and/or immature plant part contains phenols in total amounts greater than 17.0 mg/gm (dry weight).

8. A process as defined in claim 5, wherein said leafy and/or immature plant part contains combined amounts of 4-hydroxycinnamic acid and 4-hydroxy-3-methoxycinnamic acid totaling no more than 1.5 mg/gm (dry weight).

9. A process as defined in claim 5, wherein said leafy and/or immature plant part is obtained from an immature com plant, Zea mays.

10. A process as defined in claim 9, wherein said immature corn plant has been grown to a height between about 45 centimeters and about 122 centimeters.

11. A process as defined in claim 9, wherein said immature corn plant has been grown to a height that does not exceed between about 30 centimeters and about 45 centimeters.

12. A process as defined in claim 9, wherein said immature corn plant has been grown for less than ten weeks after planting.

13. A process as defined in claim 1, wherein said 6-methoxy-2,3-benzoxazolinone is administered in a manner selected from the group consisting of:

(1) oral administration;

(2) intranasal administration;

(3) transmucosal administration;

(4) parenteral injection;

(5) implant for sustained release; and

(6) transdermal patch.

14. A process as defined in claim 4, wherein a portion of said amount of 6-methoxy-2,3-benzoxazolinone is obtained by at least one of chemical synthesis or is isolated, extracted and/or purified from a natural plant or animal source.

15. A process as defined in claim 1, wherein said 6-methoxy-2,3-benzoxazolinone is obtained from one or more monocotyledonous plants and standardized with synthesized 6-methoxy-2,3-benzoxazolinone.

16. A process as defined in claim 2, said composition being administered to a human, said amount of 6-methoxy-2,3-benzoxazolinone further enhancing mood and/or treating at least one of fibromyalgia, sleep disorder, hyperglycemia, arthritis, physical or psychological condition caused by stress, or substance addiction in said human.

17. A process for promoting weight loss and/or suppressing appetite and/or enhancing mood and/or treating at least one of fibromyalgia, sleep disorder, hyperglycemia, arthritis, physical or psychological condition caused by stress, or substance addiction in a human by the administration of an amount of 6-methoxy-2,3-benzoxazolinone defined as:

18. A process as defined in claim 17, wherein said 6-methoxy-2,3-benzoxazolinone is isolated, extracted and/or purified at least in part from a leafy and/or immature plant part of one or more monocotyledonous plants selected from the group consisting of corn, wheat, barley, rye, oats, rice, sorghum, millet, bamboo, Job'"'"'s Tears, barley-like grasses, and wild grasses.

19. A process as defined in claim 17, the process comprising enhancing mood and/or treating a mental or mood disorder in a human caused by stress.

20. A process for promoting weight loss and/or suppressing appetite and/or enhancing mood and/or treating physical or psychological effects of stress in a human by the administration of an amount of 6-methoxy-2,3-benzoxazolinone defined as: