Saccharide-measuring fluorescent monomer, saccharide-measuring fluorescent sensor substance, and implantable, saccharide-measuring sensor

• US 7,524,985 B2
• Filed: 08/07/2007
• Issued: 04/28/2009
• Est. Priority Date: 07/23/2004
• Status: Active Grant

• Current Assignee: Terumo Kabushiki Kaisha (Terumo Corporation)
• Original Assignee: Terumo Kabushiki Kaisha (Terumo Corporation)
• Inventors: Ochiai, Shouji, Matsumoto, Atsushi, Kawanishi, Tetsuro
• Primary Examiner(s): Witherspoon; Sikarl A
• Assistant Examiner(s): Nwaonicha; Chukwuma O
• Application Number:
  US11/890,518
• Publication Number:
  US 20080021236A1
• Time in Patent Office: 630 Days
• Field of Search: 600/317, 562/7
• US Class Current: 562/7
• CPC Class Codes: C07F 5/025 Boronic and borinic acid compounds
• CPC Class Codes: C09K 11/06 containing organic luminescent materials
• CPC Class Codes: C09K 2211/1007 Non-condensed systems
• CPC Class Codes: C09K 2211/1011 Condensed systems
• CPC Class Codes: C09K 2211/1014 bridged by heteroatoms, e.g. N, P, Si or B

Abstract

A fluorescent monomer compound represented by the following formula (1) is provided:

wherein Q, Q′ and D³ may be the same or different, may be combined together into a fused ring, and are each a substituent selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group, and substituted or unsubstituted alkyl, acyl, oxyalkyl, carboxyl, carboxylate ester, carboxamido, cyano, nitro, amino and aminoalkyl groups; and D¹, D² and D⁴ each represent a substituent, wherein at least one of D¹, D² and D⁴ is a substituent group comprising a vinyl group at an end thereof, and wherein the substituent group comprising a vinyl group at an end thereof enables the fluorescent monomer compound to be soluble in water.

Claims

1. A fluorescence sensor substance comprising a compound represented by the following formula (7):

2. The fluorescence sensor substance according to claim 1, wherein Y comprises a structure represented by the following formula (4) or formula (5):

3. The fluorescence sensor substance according to claim 1, wherein D¹⁰, D²⁰, D³⁰ and D⁴⁰ have the meanings as defined under said definition (x), and Y comprises one or more of an amino group, carboxy group, sulfo group, nitro group, phosphate group, hydroxyl group, and/or a group comprising an ether, amide and/or ester linkage, wherein Y has a number of atoms of from 3 to 500.

4. The fluorescence sensor substance according to claim 1, wherein at least a portion of said copolymer comprises intermolecular crosslinks formed therein, and has a three-dimensional crosslinked structure.

5. An implantable, glucose-measuring sensor comprising the fluorescence sensor substance as defined in claim 1.