Microfluidic design automation method and system

• US 7,526,741 B2
• Filed: 10/29/2004
• Issued: 04/28/2009
• Est. Priority Date: 06/27/2000
• Status: Expired due to Fees

• Current Assignee: Fluidigm Corporation
• Original Assignee: Fluidigm Corporation
• Inventors: Worthington, Gajus, Harris, Gregory, Montgomery, James, Lee, Michael
• Primary Examiner(s): Kik; Phallaka
• Application Number:
  US10/976,643
• Publication Number:
  US 20050065735A1
• Time in Patent Office: 1,642 Days
• Field of Search: 716/5, 716/13, 703/9, 703/16, 703/2
• US Class Current: 716/106
• CPC Class Codes: B01F 33/30 Micromixers
• CPC Class Codes: B01F 35/50 Mixing receptacles
• CPC Class Codes: B01F 35/561 the mixer being built-up from a plurality of modules or stacked plates comprising complete or partial elements of the mixer
• CPC Class Codes: B01J 2219/00997 Strategical arrangements of multiple microreactor systems
• CPC Class Codes: B01L 2200/12 Specific details about manufacturing devices
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: B81B 1/00 Devices without movable or flexible elements, e.g. microcapillary devices
• CPC Class Codes: B81C 99/006 Design; Simulation
• CPC Class Codes: G06F 2111/10 Numerical modelling
• CPC Class Codes: G06F 2115/04 Micro electro-mechanical systems [MEMS]
• CPC Class Codes: G06F 30/00 Computer-aided design [CAD]
• CPC Class Codes: G06F 30/18 Network design, e.g. design based on topological or interconnect aspects of utility systems, piping, heating ventilation air conditioning [HVAC] or cabling circuit design at the physical level G06F30/39; network planning tools for wireless communication networks H04W16/18
• CPC Class Codes: H01H 2029/008 using micromechanics, e.g. micromechanical liquid contact switches or [LIMMS]

Abstract

The present invention generally relates to microfluidics and more particularly to the design of customized microfluidic systems using a microfluidic computer aided design system. In one embodiment of the present invention a microfluidic circuit design method is provided. The method includes developing synthesizable computer code for a design. Next, a microfluidic circuit schematic, including a plurality of symbols for microfluidic components, is generated either interactively or using the synthesizable computer code. The microfluidic circuit schematic is then functionally simulated. The microfluidic components are placed and routed on a template to form a physical layout. Then the physical layout is physically simulated using dynamic simulation models of the microfluidic components; and the physical layout is written to a layout file.

Claims

1. A method for validating a physical layout of a microfluidic circuit design comprising a plurality of microfluidic components, said method comprising:

providing said plurality of microfluidic components on a template to form said physical layout of said microfluidic circuit design;

extracting a netlist information from said physical layout;

connecting said plurality of microfluidic components automatically; and

physically simulating said physical layout by using a dynamic simulation model for each component of said plurality of microfluidic components on said template and said netlist information, wherein physically simulating said physical layout comprises simulating actuation of dynamic fluid flow in the components using control signals generated by a Boolean based language.

2. The method of claim 1 wherein physically simulating said physical layout uses a commercially available computer software with a capability to perform laminar computational fluidic dynamic and coupled physics simulations.

3. The method of claim 1 wherein physically simulating said physical layout comprises at least one of analyzing dynamic volumetric flow rates in the components, analyzing component volumes, and analyzing volumetric capacitances of interconnecting and routing channels in the physical layout.

4. The method of claim 1 further comprising modifying the physical layout based on results of the physical simulation.

5. The method of claim 1 further comprising modifying the design based on results of the physical simulation.

6. The method of claim 1 further comprising writing the physical layout to a layout file to be used for manufacturing.

7. The method of claim 6 wherein said layout file is in a format selected from the group consisting of Gerber, Postscript, EPS, DXF, GDS II, and HPGL (Hewlett-Packard Graphics Language).

8. A method for device implementation of a microfluidic circuit comprising a plurality of microfluidic components, said method comprising:

providing said plurality of microfluidic components on a template to form a physical layout of said microfluidic circuit design;

connecting said plurality of microfluidic components automatically, wherein the microfluidic components have associated VHDL-AMS or Verilog-AMS models;

writing said physical layout to a layout file to be used for manufacturing;

selecting a pattern for a die to be repetitively laid out on a wafer, said die comprising said physical layout; and

automatically laying out said pattern on said wafer by using said layout file.

9. The method of claim 8 wherein said layout file is in a format selected from the group consisting of Gerber, Postscript, EPS, DXF, GDS II, and HPGL (Hewlett-Packard Graphics Language).

10. A microfluidic circuit design method comprising:

developing synthesizable computer code for a design;

generating a microfluidic circuit schematic, comprising a plurality of symbols for microfluidic components, using said synthesizable computer code;

functionally simulating said microfluidic circuit schematic;

placing and routing on a template said microfluidic components to form a physical layout;

connecting said plurality of microfluidic components automatically, wherein the microfluidic components have associated VHDL-AMS or Verilog-AMS models;

physically simulating said physical layout using dynamic simulation models of said microfluidic components; and

writing to a layout file said physical layout.

11. The microfluidic circuit design method of claim 10 further comprising laying out a die comprising said design on a wafer by using a mask of said layout file.

12. The method of claim 10 wherein the microfluidic components are selected from the group consisting of channels, pumps, valves, chambers, oscillators, and layer interconnects.

13. The method of claim 10 wherein the microfluidic components are selected from normalized, custom, pre-defined, and user-defined components.

14. The method of claim 10 wherein the microfluidic components are routed according to preset design rules.

15. The method of claim 10 wherein the microfluidic components are assigned physical properties.

16. The method of claim 10 wherein the microfluidic components are active fluidic components.

17. A microfluidic circuit design system comprising:

a synthesis module for synthesizing software of a design into a schematic having a plurality of connected symbols of microfluidic components;

a design capture module for displaying said schematic;

a functional analysis module for functionally simulating selected microfluidic components of the schematic;

a physical implementation module for placing and routing said microfluidic components into a physical layout according to said design;

a physical layout module including an auto-routing module for connecting said microfluidic components automatically; and

a physical analysis module for physically simulating the components in the physical layout, wherein physically simulating said physical layout comprises simulating actuation of dynamic fluid flow in the components using control signals generated by a Boolean based language.

18. The system of claim 17 wherein the modules comprise instructions stored in a computer-readable medium.

19. A system for physically laying out a microfluidic circuit having a plurality of microfluidic components, comprising:

a library module comprising information associated with said plurality of microfluidic components;

a design rule checking module having a plurality of layout rules, wherein said design rule checking module is configured to perform at least one check on I/O placement, channel size mismatch, and dangling channels; and

a physical layout module for placing and routing said plurality of microfluidic components on a template using said information and said plurality of layout rules, wherein said physical layout module includes an auto-routing module for connecting said plurality of microfluidic components automatically.

20. The method of claim 19 wherein said plurality of microfluidic components include channels, pumps, valves, chambers, and layer interconnects.

21. A system for analyzing a micro fluidic circuit having a plurality of microfluidic components, comprising:

a physical layout comprising said plurality of microfluidic components, after placement and routing on a template;

an auto-routing module for connecting said plurality of microfluidic components automatically;

a model library comprising dynamic simulation models for said plurality of microfluidic components, wherein the microfluidic components have associated VHDL-AMS or Verilog-AMS models; and

a dynamic microfluidic simulator for simulating said physical layout using said dynamic simulation models.

22. A computer program product stored in a computer readable medium for validating a physical layout of a microfluidic circuit design comprising a plurality of microfluidic components, said computer program product comprising:

code for providing said plurality of microfluidic components on a template to form said physical layout of said micro fluidic circuit design;

code for connecting said plurality of microfluidic components automatically;

code for extracting a netlist information from said physical layout; and

using a dynamic simulation model for each component of said plurality of microfluidic components on said template and said netlist information, code for physically simulating said physical layout, wherein physically simulating said physical layout comprises simulating actuation of dynamic fluid flow in the components using control signals generated by a Boolean based language.

23. A computer program product stored in a computer readable medium for device implementation of a microfluidic circuit comprising a plurality of microfluidic components, said computer program product comprising:

code for providing said plurality of microfluidic components on a template to form a physical layout of said microfluidic circuit design;

code for connecting said plurality of microfluidic components automatically, wherein the microfluidic components have associated VHDL-AMS or Verilog-AMS models;

code for writing said physical layout to a layout file to be used for manufacturing;

code for selecting a pattern for a die to be repetitively laid out on a wafer, said die comprising said physical layout; and

code for automatically laying out said pattern on said wafer by using said layout file.