Genetic products differentially expressed in tumors and the use thereof

• US 7,527,933 B2
• Filed: 11/21/2003
• Issued: 05/05/2009
• Est. Priority Date: 11/22/2002
• Status: Expired due to Term

• Current Assignee: Ganymed Pharmaceuticals AG (Astellas Pharma Incorporated)
• Original Assignee: Ganymed Pharmaceuticals AG (Astellas Pharma Incorporated)
• Inventors: Sahin, Ugur, Koslowski, Michael, Tureci, Ozlem
• Primary Examiner(s): Canella; Karen A
• Assistant Examiner(s): Reddig; Peter J
• Application Number:
  US10/537,002
• Publication Number:
  US 20060035852A1
• Time in Patent Office: 1,992 Days
• Field of Search: 435/4
• US Class Current: 435/7.1
• CPC Class Codes: A61K 2039/505 comprising antibodies
• CPC Class Codes: A61K 47/549 Sugars, nucleosides, nucleotides or nucleic acids
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 1/18 for pancreatic disorders, e.g. pancreatic enzymes
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 13/08 of the prostate
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07K 14/47 from mammals
• CPC Class Codes: C07K 16/18 against material from animals or humans
• CPC Class Codes: C07K 16/30 from tumour cells
• CPC Class Codes: C07K 16/3023 Lung
• CPC Class Codes: C07K 16/3046 Stomach, Intestines
• CPC Class Codes: C07K 16/3076 against structure-related tumour-associated moieties
• CPC Class Codes: C07K 2317/30 characterized by aspects of specificity or valency
• CPC Class Codes: C07K 2317/34 Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
• CPC Class Codes: G01N 33/57484 involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites

Abstract

The invention relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the invention also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for the polypeptides, peptides and proteins.

Claims

1. A method of diagnosing lung, pancreatic, or esophageal cancer, comprising detecting expression of a tumor-associated antigen in a biological sample, wherein the tumor-associated antigen is selected from the group consisting of:

(i) the polypeptide of SEQ ID NO;

16; and

(ii) the polypeptide encoded by the nucleic acid of SEQ ID NO;

7,

wherein detection of the tumor-associated antigen in a biological sample isolated from a patient in an amount greater than an amount of the tumor-associated antigen in a normal biological sample indicates the presence of lung, pancreatic, or esophageal cancer.

2. The method of claim 1, in which the detection comprises:

(i) contacting the biological sample with an antibody which binds specifically to the tumor-associated antigen; and

(ii) detecting a complex formed between the antibody and the tumor-associated antigen.

3. The method of claim 2, wherein the antibody is labeled with a detectable marker.

4. The method of claim 3, wherein the detectable marker is a radioactive marker or an enzymatic marker.

5. The method of claim 1, wherein the biological sample comprises body fluid or body tissue.