Interferon-beta-1a-immunoglobulin fusion proteins and uses
First Claim
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1. An isolated DNA encoding a fusion polypeptide comprising:
- (a) an amino acid sequence, the amino acid sequence being located in the amino terminal region of said fusion polypeptide, selected from the group consisting of SEQ ID NOs;
45-59; and
(b) a hinge, CH2 and CH3 domains of an immunoglobulin, said domains being located in the carboxy terminal region of the fusion polypeptide.
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Abstract
A fusion polypeptide is described having the amino acid sequence X-Y-Z, or portion thereof, comprising the amino acid sequence of a glycosylated interferon-beta (X); Y is an optional linker moiety; and Z is a polypeptide comprising at least a portion of a polypeptide other than glycosylated interferon-beta. It is preferred that X is human interferon-beta-1a. Mutants of interferon-beta-1a are also described.
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Citations
10 Claims
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1. An isolated DNA encoding a fusion polypeptide comprising:
- (a) an amino acid sequence, the amino acid sequence being located in the amino terminal region of said fusion polypeptide, selected from the group consisting of SEQ ID NOs;
45-59; and
(b) a hinge, CH2 and CH3 domains of an immunoglobulin, said domains being located in the carboxy terminal region of the fusion polypeptide. - View Dependent Claims (2, 3, 4, 5)
- (a) an amino acid sequence, the amino acid sequence being located in the amino terminal region of said fusion polypeptide, selected from the group consisting of SEQ ID NOs;
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6. A pharmaceutical composition comprising a therapeutically effective amount of the a fusion polypeptide comprising:
- (a) an amino acid sequence selected from the group consisting of SEQ ID NOs;
45-59; and
(b) a hinge, CH2 and CH3 domains of an immunoglobulin. - View Dependent Claims (7, 8, 9, 10)
- (a) an amino acid sequence selected from the group consisting of SEQ ID NOs;
Specification