High resolution radio frequency medical imaging and therapy system

• US 7,529,398 B2
• Filed: 08/03/2006
• Issued: 05/05/2009
• Est. Priority Date: 08/09/2005
• Status: Expired due to Fees

• Current Assignee: Gil Zwirn, Moshe Margalit
• Original Assignee: Gil Zwirn, Moshe Margalit
• Inventors: Zwirn, Gil, Margalit, Moshe
• Primary Examiner(s): SHERALI, ISHRAT I
• Application Number:
  US11/997,913
• Publication Number:
  US 20080228062A1
• Time in Patent Office: 1,006 Days
• Field of Search: 382128-131, 382/154, 382/274, 382/275, 600/407, 600/408, 600/409, 600/430, 600/547, 600/2, 600/10, 324/637, 324/638, 324/639
• US Class Current: 382/131
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61B 5/0046 Arrangements of imaging apparatus in a room, e.g. room provided with shielding or for improved access to apparatus
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/0507 using microwaves or terahertz waves
• CPC Class Codes: A61N 5/02 using microwaves

Abstract

A method for imaging includes directing a plurality of radio frequency (RF) beams (206, 207) toward a target organ from a plurality of angles. The RF beams include one or more first pairs of the RF beams, each first pair including two of the RF beams that impinge on the target organ from opposite directions. RF signals reflected from the target organ are received responsively to the RF beams, the RF signals including one or more second pairs of the RF signals engendered respectively by the one or more first pairs of the RF beams. Local tissue parameters at multiple points in the target organ are extracted by jointly processing the RF signals in each of the second pairs. Images of the target organ are produced using the extracted local tissue parameters. Other embodiments described herein include methods for passive imaging, motion vector analysis, ablation, local heating and application of electromagnetic pressure.

Claims

1. A method for imaging, comprising:

directing a plurality of radio frequency (RF) beams toward a target organ from a respective plurality of angles, the plurality of the RF beams comprising one or more first pairs of the RF beams, each first pair comprising two of the RF beams that impinge on the target organ from opposite directions;

receiving RF signals reflected from the target organ responsively to the RF beams, the RF signals comprising one or more second pairs of the RF signals engendered respectively by the one or more first pairs of the RF beams using a processor to perform the following steps;

extracting local tissue parameters at multiple points in the target organ by jointly processing the RF signals in each of the second pairs; and

producing images of the target organ using the extracted local tissue parameters.

2. The method according to claim 1, wherein directing the plurality of the RF beams comprises forming a respective plurality of effective antennas directed to the target organ from the plurality of the angles by selectively activating subsets of radiating elements selected from an antenna array comprising a plurality of the radiating elements.

3. The method according to claim 1, wherein directing the plurality of the RF beams comprises at least one of:

mechanically scanning one or more antennas so as to transmit from the plurality of the angles; and

mechanically scanning the target organ with respect to one or more antennas so as to cause the RF beams generated by the antennas to impinge on the target organ from the plurality of the angles.

4. The method according to claim 1, wherein directing the plurality of the RF beams comprises transmitting one or more wideband RF pulses in each of the RF beams.

5. The method according to claim 4, wherein transmitting the one or more pulses comprises transmitting a sequence of two or more wideband RF pulses and phase-encoding the sequence by assigning respective phases to the pulses depending on positions of the pulses in the sequence.

6. The method according to claim 1, wherein receiving the RF signals comprises sampling the reflected RF signals using multiple analog-to-digital (A/D) converters having incremental time offsets with respect to one another, and enhancing a range resolution of the reflected RF signals using multiple outputs of the multiple analog-to-digital (A/D) converters.

7. The method according to claim 1, wherein the local tissue parameters comprise at least one parameter selected from a group of parameters consisting of a local attenuation coefficient, a local reflection coefficient, a local time delay and a local tissue dielectric property.

8. The method according to claim 1, wherein receiving the RF signals comprises measuring for each of the second pairs first and second reflection intensity profiles indicating intensities of the RF signals in the each of the second pairs as a function of time;

wherein jointly processing the RF signals comprises comparing the first and second reflection intensity profiles; and

wherein comparing the first and second reflection intensity profiles comprises identifying in the first reflection intensity profile first reflection peaks reflected from respective tissue interfaces in a first direction, identifying in the second reflection intensity profile second reflection peaks reflected from the respective tissue interfaces in a second direction opposite to the first direction, and calculating corrected values of the local tissue parameters responsively to differences between the first and second reflection peaks.

9. The method according to claim 8, wherein calculating the local tissue parameters comprises correcting at least one artifact selected from a group consisting of a local time delay and a local attenuation in the first and second reflection intensity profiles;

wherein producing the images of the target organ comprises reconstructing a three-dimensional (3-D) representation of the local tissue parameters by calculating accumulated contributions of the corrected values of the local tissue parameters of the second pairs at the multiple points in the target organ;

wherein at least some of the RF beams overlap one another, and wherein reconstructing the 3-D representation comprises improving a spatial resolution of the 3-D representation using the overlapping RF beams; and

wherein calculating the accumulated contributions comprises calculating, for each beam, iso-time surfaces defining loci of some of the multiple points in the target organ having a particular propagation delay with respect to an antenna directing the beam.

10. The method according to claim 1, wherein directing the RF beams, receiving the RF signals and extracting the tissue parameters comprise continually scanning the target organ using the RF beams, and wherein producing the images of the target organ comprises producing a sequence of 3-D images that display a variation of the extracted tissue parameters over time.

11. The method according to claim 10, and comprising tracking a temporal variation of a tissue region by measuring differences among respective locations of the tissue region in the sequence of 3-D images.

12. The method according to claim 1, wherein producing the images of the target organ comprises at least one of:

differentiating between first and second different tissue types using the extracted local tissue parameters;

identifying a tissue type using the extracted local tissue parameters; and

measuring a local conductivity in at least some of the multiple points in the target organ using the extracted local tissue parameters.

13. The method according to claim 1, wherein directing the RF beams comprises configuring a first subset of the RF beams to use a first polarization and a second subset of the RF beams to use a second polarization different from the first polarization, and wherein extracting the local tissue parameters comprises calculating first values of the local tissue parameters responsively to the first subset of the beams and second values of the local tissue parameters responsively to the second subset of the beams.

14. The method according to claim 1, wherein receiving the RF signals comprises filtering the received RF signals to produce first and second partial bandwidth RF signals, and wherein extracting the local tissue parameters comprises calculating first values of the local tissue parameters responsively to the first partial bandwidth RF signal and second values of the local tissue parameters responsively to the second partial bandwidth RF signal.

15. The method according to claim 1, and comprising inserting a contrast agent affecting at least one of the local tissue parameters into the target organ.

16. The method according to claim 1, and comprising applying RF ablation to an ablation region in the target organ by focusing an ablating signal on the ablation region using at least some of the RF beams, wherein focusing the ablating signal on the ablation region comprises directing the ablating signal based on the produced images of the target organ.

17. The method according to claim 1, and comprising at least one of:

locally heating a region of the target organ by focusing a heating RF signal on the region using at least some of the RF beams; and

applying an electromagnetic pressure to a region of the target organ by focusing an RF signal on the region using at least some of the RF beams.

18. An imaging system, comprising:

one or more antennas, which are arranged to direct a plurality of radio frequency (RF) beams toward a target organ from a respective plurality of angles, the plurality of the RF beams comprising one or more first pairs of the RF beams, each first pair comprising two of the RF beams that impinge on the target organ from opposite directions;

a receiver, which is arranged to receive via the one or more antennas RF signals reflected from the target organ responsively to the RF beams, the RF signals comprising one or more second pairs of the RF signals engendered respectively by the one or more first pairs of the RF beams; and

a processor, which is arranged to extract local tissue parameters at multiple points in the target organ by jointly processing the RF signals in each of the second pairs and to produce images of the target organ using the extracted local tissue parameters.

19. The system according to claim 18, wherein the one or more antennas comprise an antenna array comprising a plurality of radiating elements, and comprising a switching array, which is controlled by the processor and arranged to form a plurality of effective antennas directed to the target organ from the plurality of the angles by selectively activating subsets of the radiating elements.

20. The system according to claim 19, wherein the antenna array comprises a cylindrical array surrounding the target organ, and wherein the RF beams are parallel, with an offset no greater than one degree, to a base of the cylinder and point toward a central axis of the cylinder from multiple azimuth angles and heights.

21. The system according to claim 18, and comprising means for at least one of:

arranging the one or more antennas to mechanically scan the target organ so as to transmit from the plurality of the angles; and

mechanically scanning the target organ with respect to one or more antennas so as to cause the RF beams generated by the antennas to impinge on the target organ from the plurality of the angles.

22. The system according to claim 18, and comprising a transmitter, which is arranged to drive the antennas with one or more wideband RF pulses.

23. The system according to claim 18, wherein the receiver comprises multiple analog-to-digital (A/D) converters, which are arranged to sample the reflected RF signals at incremental time offsets with respect to one another;

and

wherein the processor is arranged to enhance a range resolution of the reflected RF signals using multiple outputs of the multiple analog-to-digital (A/D) converters.

24. The system according to claim 18, wherein the processor is arranged to carry out at least one of:

measure for each of the second pairs first and second reflection intensity profiles indicating intensities of the RF signals in the each of the second pairs as a function of time, and to extract the local tissue parameters by comparing the first and second reflection intensity profiles;

identify in the first reflection intensity profile first reflection peaks reflected from respective tissue interfaces in a first direction, to identify in the second reflection intensity profile second reflection peaks reflected from the respective tissue interfaces in a second direction opposite to the first direction, and to calculate corrected values of the local tissue parameters responsively to differences between the first and second reflection peaks;

correct at least one artifact selected from a group consisting of a local time delay and a local attenuation in the first and second reflection intensity profiles;

reconstruct a three-dimensional (3-D) representation of the local tissue parameters by calculating accumulated contributions of the corrected values of the local tissue parameters of the second pairs at the multiple points in the target organ;

track a temporal variation of a tissue region by measuring differences among respective locations of the tissue region in the sequence of 3-D images;

differentiate between first and second different tissue types using the extracted local tissue parameters;

identify a tissue type using the extracted local tissue parameters; and

measure a local conductivity in at least some of the multiple points in the target organ using the extracted local tissue parameters.

25. The system according to claim 18, wherein said one or more antennas and said processor are arranged to apply RF ablation to an ablation region in the target organ, by focusing an ablation signal on said ablation region using at least some of the RF beams;

and

wherein said processor is arranged to control the one or more antennas to direct the ablation signal according to a produced image of the target organ.