Use of nitric oxide gas in an extracorporeal circuitry to treat blood plasma
First Claim
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1. A method of reducing pathogens in blood, the method comprising:
- obtaining blood from a mammal or a blood source;
separating the blood into plasma and blood cells;
exposing the plasma to nitric oxide containing gas;
combining the exposed plasma with the blood cells;
reducing nitric oxide gas content in the recombined blood by contacting the recombined blood with a gaseous source having a nitric oxide content that is less than the recombined blood; and
returning the recombined blood to the mammal or blood source.
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Abstract
A method of reducing pathogens in blood by exposure to a nitric oxide containing gas in an extracorporeal circuitry is provided. The method includes: obtaining blood from a mammal or a blood source, separating the blood into plasma and blood cells, exposing the plasma to nitric oxide containing gas, combining the exposed plasma with the blood cells, reducing nitric oxide content in the recombined blood, and returning the blood to the mammal or blood source.
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Citations
42 Claims
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1. A method of reducing pathogens in blood, the method comprising:
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obtaining blood from a mammal or a blood source; separating the blood into plasma and blood cells; exposing the plasma to nitric oxide containing gas; combining the exposed plasma with the blood cells; reducing nitric oxide gas content in the recombined blood by contacting the recombined blood with a gaseous source having a nitric oxide content that is less than the recombined blood; and returning the recombined blood to the mammal or blood source. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. An extracorporeal blood circuit comprising:
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an inlet line adapted to obtain blood from a mammal or a blood source; an outlet line adapted to return blood to the mammal or blood source; a fluid circuit for fluid communication between the inlet and the outlet line, wherein the fluid circuit comprises; at least one pump acting on the fluid circuit to circulate the blood therethrough; a separation unit in fluid communication with the inlet line, wherein the separation unit is adapted to separate the blood received from the mammal or source into plasma and blood cells; a nitric oxide unit that exposes the plasma with a nitric oxide containing gas; a mixer for combining the exposed plasma with the blood cells; and a reduction unit for reducing the nitric oxide content in the recombined blood, wherein the reduction unit is in fluid communication with the outlet line and contacts the recombined blood with a gaseous source having a nitric oxide content that is less than the recombined blood. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21)
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22. A method of reducing pathogens in blood, the method comprising:
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obtaining blood from a mammal or a blood source; separating the blood into plasma and blood cells; exposing the plasma to nitric oxide containing gas; combining the exposed plasma with the blood cells; reducing nitric oxide gas content in the recombined blood by providing a semipermeable membrane selectively permeable to nitric oxide gas in between the recombined blood and a gaseous source; and returning the recombined blood to the mammal or blood source. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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34. An extracorporeal blood circuit comprising:
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an inlet line adapted to obtain blood from a mammal or a blood source; an outlet line adapted to return blood to the mammal or blood source; a fluid circuit for fluid communication between the inlet and the outlet line, wherein the fluid circuit comprises; at least one pump acting on the fluid circuit to circulate the blood therethrough; a separation unit in fluid communication with the inlet line, wherein the separation unit is adapted to separate the blood received from the mammal or source into plasma and blood cells; a nitric oxide unit that exposes the plasma with a nitric oxide gas containing gas; a mixer for combining the exposed plasma with the blood cells; and a reduction unit for reducing the nitric oxide content in the recombined blood, wherein the reduction unit is in fluid communication with the outlet line and comprises a semipermeable membrane selectively permeable to nitric oxide gas operably fitted in between the combined blood and a gaseous source. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42)
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Specification