Multimodal method for identifying hazardous agents
First Claim
1. A method of assessing occurrence of a pathogen in a sample that comprises multiple entities, the method comprising assessing a first optical property of the entities, wherein the first optical property is characteristic of the pathogen, selecting only an entity exhibiting the first optical property and thereafter performing an assessment of Raman-shifted radiation scattered by the selected entity, wherein one or more entities failing to exhibit said first optical property are excluded from said assessment wherein exhibition of a Raman scattering property characteristic of the pathogen by the selected entity is indicative that the pathogen occurs in the sample.
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Abstract
The invention relates to apparatus and methods for assessing occurrence of a hazardous agent in a sample by performing multimodal spectral analysis of the sample. Methods of employing Raman spectroscopy for entities in a sample which exhibit one or more optical properties characteristic of a hazardous agent are disclosed. Devices and systems suitable for performing such methods are also disclosed.
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Citations
35 Claims
- 1. A method of assessing occurrence of a pathogen in a sample that comprises multiple entities, the method comprising assessing a first optical property of the entities, wherein the first optical property is characteristic of the pathogen, selecting only an entity exhibiting the first optical property and thereafter performing an assessment of Raman-shifted radiation scattered by the selected entity, wherein one or more entities failing to exhibit said first optical property are excluded from said assessment wherein exhibition of a Raman scattering property characteristic of the pathogen by the selected entity is indicative that the pathogen occurs in the sample.
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31. A device for assessing occurrence of a pathogen in a sample that comprises multiple entities, the device comprising a radiation source for irradiating the sample, a detector for detecting an optical property of the entities, a Raman detector for detecting Raman-shifted radiation scattered by the entities, and a controller operably linked to the Raman detector wherein said controller restricts detection of Raman-shifted radiation only to entities for which the optical property is characteristic of the pathogen.
- 32. A device for assessing occurrence of a pathogen in an ambient sample, the device comprising an air handling system for depositing particles in the ambient air on a substrate, a radiation source for irradiating the substrate, a detector for detecting an optical property of the particles deposited on the substrate, a Raman detector for detecting Raman-shifted radiation scattered by the particles deposited on the substrate, and a controller operably linked to the Raman detector, wherein said controller restricts detection of Raman-shifted radiation only to particles for which the optical property is characteristic of the pathogen.
Specification