Bronchoscopic repair of air leaks in a lung

• US 7,533,671 B2
• Filed: 12/22/2003
• Issued: 05/19/2009
• Est. Priority Date: 08/08/2003
• Status: Active Grant

• Current Assignee: Gyrus ACMI, Inc. (Olympus Corporation)
• Original Assignee: Spiration, Inc. (Olympus Corporation)
• Inventors: Springmeyer, Steven C, Sirokman, William A., Gonzalez, Hugo Xavier
• Primary Examiner(s): GHERBI, SUZETTE JAIME J
• Application Number:
  US10/745,401
• Publication Number:
  US 20050137714A1
• Time in Patent Office: 1,975 Days
• Field of Search: 623/9, 623 2365- 2368, 12820712-20716
• US Class Current: 128/207.12
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12104 in an air passage
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 2017/00809 Lung operations
• CPC Class Codes: A61B 2017/12054 Details concerning the detachment of the occluding device from the introduction device
• CPC Class Codes: A61F 2002/043 Bronchi

Abstract

Methods and systems for minimally invasively treating an air leak in a lung comprise the steps of detecting an air leak in a lung; locating an airway in fluid communication with the air leak, introducing a bronchoscope into a patient'"'"'s airway to a position adjacent the target section and occluding an airway upstream of the air leak for a period of time. The airway occlusion is preferably removed after the air leak has substantially permanently healed. The method can also include the injection of a substance into the airway on a distal side of the occlusion.

Claims

1. A method of treating an air leak within a lung, the method comprising:

detecting an air leak in a lung;

identifying an airway in fluid communication with the air leak using an inflatable balloon;

measuring a diameter of said airway in fluid communication with the air leak, wherein the measuring step is performed simultaneously with the identifying step and wherein the identifying and measuring steps are performed in multiple locations to generate a map of multiple portions of airways in fluid communication with the air leak; and

deploying a one-way valve in the airway, the one-way valve being adapted to allow air to flow in an expiratory direction, while preventing air from flowing in an inspiratory direction past the valve.

2. The method of claim 1, wherein the step of identifying an airway is performed using a balloon catheter.

3. The method of claim 1, wherein the valve comprises a plurality of anchors configured to secure the valve in a deployed target location.

4. The method of claim 1, wherein the valve comprises a membrane surrounding a radially-expandable frame.

5. The method of claim 1, wherein the valve is configured to allow fluid to flow between the valve and an airway wall in a proximal direction.

6. The method of claim 1, wherein the valve is configured to allow mucoscilliary transport in a proximal direction past the valve.

7. The method of claim 1, further comprising the step of removing the valve after a pre-determined length of time.

8. The method of claim 1, further comprising the steps of identifying additional airways within the lung in fluid communication with the fistula and deploying an intra-bronchial valve in each of the additional airways.

9. The method of claim 1, wherein the one-way valve comprises a central removal rod.

10. The method of claim 9, wherein the rod extends axially from a central portion of an hourglass-shaped frame, and wherein a proximal portion of the hourglass-shaped frame is covered by a flexible, air impermeable membrane.

11. A method of treating an air leak within a lung, the method comprising:

detecting an air leak in a lung;

providing a balloon catheter configured to temporarily occlude airways within a lung;

guiding the balloon catheter to a selected airway within the lung;

inflating the balloon in the selected airway until the selected airway is occluded;

recording a decrease in an air leak rate correlating to the occluding of the selected airway;

measuring a size of the airway while the balloon is inflated;

deflating the balloon;

repeating the guiding, inflating, recording and measuring steps at another location until a desired location is identified and

deploying a one-way valve in the airway in the desired location to occlude airflow in at least an inspiratory direction.

12. The method of claim 11, further comprising the step of removing the one-way valve after a pre-determined length of time.

13. The method of claim 11, wherein the one-way valve comprises an expandable frame, a portion of the frame being covered by a flexible membrane.

14. The method of claim 13, wherein the one-way valve is configured to allow fluid to pass between the membrane and an airway wall in a proximal direction.

15. The method of claim 14, wherein the one-way valve comprises a retrieval rod extending proximally from the valve for removal of the valve from a patient'"'"'s airway.

16. The method of claim 14, wherein a portion of the valve is made of a bioabsorbable polymer configured to eliminate the occlusion of airflow after a pre-determined period of time.