Implantable device with sensors for differential monitoring of internal condition

• US 7,534,207 B2
• Filed: 02/26/2004
• Issued: 05/19/2009
• Est. Priority Date: 02/07/2003
• Status: Expired due to Fees

• Current Assignee: Photosonics Medical, Inc.
• Original Assignee: The Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California (University of Southern California)
• Inventors: Jabbour, Nicolas, Shehada, Ramez Emile Necola
• Primary Examiner(s): Mallar; Patricia
• Assistant Examiner(s): Toth; Karen E
• Application Number:
  US10/789,492
• Publication Number:
  US 20040236192A1
• Time in Patent Office: 1,909 Days
• Field of Search: 600309-342, 600/373
• US Class Current: 600/309
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/103 Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes A61B5/08 takes precedence; measuring aids for tailors A41H1/00; measuring instruments specially adapted for dentistry A61C19/04
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/413 Monitoring transplanted tissue or organ, e.g. for possible rejection reactions after a transplant
• CPC Class Codes: A61B 5/6882 Anchoring means

Abstract

The present invention is directed to implantable devices and systems for the differential monitoring the condition of the tissue or fluid emitted from the site in proximity to the implants. The invention may also include modifications of the implantable device to stabilize or immobilize the device in the proximity of the tissue to be monitored.

Claims

1. A method of monitoring the condition of a tissue comprising:

receiving information from a first sensing system and a second sensing system, wherein the first and second sensing systems are configured to sense a physiological property of a tissue;

processing information from the first and second sensing systems to compute a difference in information sensed by the first and second sensing systems;

displaying data on a display regarding the difference between the information received from the first and second sensing systems;

positioning an icon representing a device depicted on the display relative to a depiction of the tissue to indicate the position of the device within the body; and

monitoring the information received from the first and second sensing systems to evaluate the condition of the tissue over time.

5. The method of claim 1, wherein the physiological property is oxygenation and wherein the condition of the first tissue is determined to be normal:

if the oxygenation sensed by the first sensing system is normal.

6. The method of claim 1, wherein the physiological property is oxygenation and wherein the condition of the first tissue is determined to be abnormal:

If the sensed oxygenation sensed by the first sensing system is abnormally low and the oxygenation sensed by the second sensing system is normal.

7. The method of claim 1, wherein the physiological property is oxygenation and wherein the condition of the first tissue is not determined to be abnormal:

if the oxygenation sensed by the first and the second sensing system are abnormally low.

2. A method of monitoring the condition of a tissue comprising:

implanting a device within a body in proximity to a tissue to be monitored, wherein the device includes the first sensing system and a second sensing system, wherein the first and second sensing systems are configured to sense a physiological property of tissue;

orienting the device such that the first sensing system senses the physiological property of a first region of a tissue, and the second sensing system senses the same physiological property from a second region of a tissue;

displaying the orientation of the device relative to the first and the second region of the tissue on a display; and

positioning an icon representing a device depicted on the display relative to a depiction of the tissue to indicate the position of the device within the body.

3. A method of monitoring the condition of a tissue comprising:

implanting a device within a body in proximity to tissue to be monitored, wherein the device includes the first sensing system and a second sensing system, wherein the first and second sensing systems are configured to sense a physiological property of tissue;

orienting the device such that the first sensing system senses the physiological property of a first tissue, and the second sensing system senses the same physiological property from a second tissue;

displaying the orientation of the device relative to the first and the second tissue on a display; and

positioning an icon representing the device depicted on the display relative to a depiction of the tissue to indicate the position of the device within the body.

4. A system for monitoring tissue condition comprising:

a housing configured to be implanted between a first tissue and a different second tissue within a patient'"'"'s body, the housing including a first surface located on a first outer side of the housing configured to rest against the first tissue, and a second surface located on a second outer side of the housing, opposite from the first outer side, configured to rest against the second tissue;

a first sensing system proximate to the first surface configured to sense a physiological property-of the first tissue;

a second sensing system proximate to the second surface configured to sense the same physiological property of the second tissue; and

a processing system in communication with the first and second sensing systems configured to compute a difference between the physiological property oxygenation sensed by the first and second sensing systems;

a display configured to depict information about the physiological property sensed by the first or second sensing systems, and to depict an icon representing the device on the display relative to a depiction of the tissue to indicate the position of the device within the body.

8. A method for determining the condition of a transplanted tissue within a patient'"'"'s body relative to the condition of surrounding tissue comprising:

implanting a sensing device within the patient'"'"'s body in proximity to a transplanted tissue and a different native tissue, wherein the device includes the first sensing system and a second sensing system;

orienting the device such that the first sensing system senses the oxygenation of the transplanted tissue, and the second sensing system senses the oxygenation of the native tissue;

comparing the sensed oxygenations by the first and the second sensing systems; and

determining whether the condition of the transplanted tissue is normal based on the comparison.

9. The method of claim 8, wherein the condition of the transplanted tissue is determined to be normal:

if the sensed oxygenation of the transplanted tissue is normal.

10. The method of claim 8, wherein the condition of the transplanted tissue is determined to be abnormal:

if the sensed oxygenation of the transplanted tissue is abnormally low and the sensed oxygenation of the second tissue is normal.

11. The method of claim 8, wherein the condition of the transplanted tissue is not determined to be abnormal:

if the sensed oxygenation by the first and the second sensing system are abnormally low.